NGF-β and BDNF levels are altered in male patients with chronic schizophrenia: effects on clinical symptoms
BMC Psychiatry,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 13, 2025
Abstract
Background
Schizophrenia,
a
severe
mental
disorder
with
complex
pathophysiology,
involves
neurotrophic
factors,
which
play
crucial
roles
in
neurodevelopment
and
neuroplasticity.
This
study
investigated
NGF-β
BDNF
levels
chronic
schizophrenia
their
association
clinical
symptoms,
cognitive
function,
1,25(OH)₂D
levels.
Methods
In
this
cross-sectional
study,
72
male
patients
70
matched
healthy
controls
were
enrolled.
Psychopathological
symptoms
assessed
using
the
Positive
Negative
Syndrome
Scale
(PANSS),
function
was
evaluated
Repeatable
Battery
for
Assessment
of
Neuropsychological
Status
(RBANS).
The
serum
NGF-β,
BDNF,
measured.
Results
Serum
(F
=
35.239,
P
<
0.001)
12.669,
significantly
decreased
compared
to
controls.
negatively
correlated
PANSS
negative
(beta
-0.205,
t
-2.098,
0.040)
positively
(
r
0.324,
0.006).
Decreased
concentrations
language
deficits
-0.301,
-2.762,
0.007).
Significant
associations
observed
between
reduced
(B
1.040,
0.001,
RR
2.829,
95%
CI:
2.101−3.811)
0.526,
1.692,
1.241−2.306).
Conclusions
Our
findings
indicated
that
altered
associated
vitamin
D
metabolism.
These
results
provided
new
insight
into
etiology
schizophrenia.
Язык: Английский
Impact of second-generation antipsychotics monotherapy or combined therapy in cytokine, lymphocyte subtype, and thyroid antibodies for schizophrenia: a retrospective study
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Окт. 16, 2024
Schizophrenia
(SCZ)
shares
high
clinical
relevance
with
the
immune
system,
and
potential
interactions
of
psychopharmacological
drugs
system
are
still
an
overlooked
area.
Here,
we
aimed
to
identify
whether
second-generation
antipsychotics
(SGA)
monotherapy
or
combined
therapy
SGA
other
psychiatric
medications
influence
routine
blood
immunity
biomarkers
patients
SCZ.
Язык: Английский
Variations in inflammatory regulators in male patients with chronic schizophrenia associated with psychopathology and cognitive deficits
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 15, 2024
Immune
dysregulation
has
been
identified
as
a
contributing
factor
in
the
pathophysiology
of
schizophrenia.
This
study
aimed
to
investigate
variations
specific
immune
regulators
and
their
correlation
with
psychopathology
cognitive
functions
male
patients
chronic
Employing
cross-sectional
design,
this
included
72
The
Positive
Negative
Syndrome
Scale
(PANSS)
Repeatable
Battery
for
Assessment
Neuropsychological
Status
were
utilized
assess
functions,
respectively.
Serum
levels
interleukin
(IL)-4,
IL-10,
IL-12p40,
IL-13,
monocyte
chemoattractant
protein-1
(MCP-1)
measured.
There
significantly
increased
IL-4,
MCP-1,
alongside
decreased
IL-10
compared
controls
(all
P
<
0.05).
IL-4
showed
significant
negative
association
PANSS
positive
symptoms
(beta=-0.222,
=
0.042).
After
controlling
antipsychotic
medication,
BMI,
smoking,
was
no
longer
(r=-0.232,
0.055).
Additionally,
correlations
(beta
0.297,
0.008),
IL-13
0.371,
0.001),
MCP-1
0.280,
0.013)
language
scores
observed.
Increased
(P
0.044,
OR
1.994),
0.019,
2.245),
well
interactions
0.043,
2.000)
positively
associated
risk
schizophrenia,
while
lower
0.003,
0.2.867)
also
linked
an
risk.
associations
between
markers
clinical
features
schizophrenia
males
underscored
potential
immune-mediated
mechanisms
underlying
Язык: Английский