Beneath the surface: unveiling the gut–brain axis in anorexia and depression
Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity,
Год журнала:
2025,
Номер
30(1)
Опубликована: Фев. 8, 2025
Anorexia
nervosa
(AN)
and
depression
are
complex
conditions
with
high
comorbidity,
impacting
mental
physical
health.
Recent
research
suggests
gut
microbiota
plays
a
significant
role
in
their
development
progression.
This
correspondence
highlights
the
critical
gaps
understanding
gut–brain
axis
AN
depression,
emphasizing
need
for
comprehensive
research.
We
discuss
recent
findings,
including
altered
profiles
inflammatory
factors,
identify
key
areas
future
investigation.
These
include
large-scale,
multi-center
studies
to
quantify
profiles,
mechanistic
of
alterations,
diagnostic
therapeutic
advances
using
as
biomarkers.
Addressing
these
is
crucial
developing
effective
treatment
strategies
improving
patient
outcomes.
By
exploring
underlying
mechanisms,
validating
biomarkers,
targeted
therapies,
we
can
enhance
accuracy,
improve
outcomes,
better
support
patients
depression.
has
potential
transform
management
quality
life
those
affected.
Level
evidence
Low
level
it
personal
opinion.
Язык: Английский
IUPHAR Review: Eating Disorders, Gut Microbiota Dysbiosis and Epigenetic Aberrations
Pharmacological Research,
Год журнала:
2025,
Номер
213, С. 107653 - 107653
Опубликована: Фев. 17, 2025
Eating
disorders
(EDs)
are
a
heterogeneous
class
of
increasing
mental
that
characterized
by
disturbances
in
eating
behaviors,
body
weight
regulation,
and
associated
psychological
dysfunctions.
These
create
physiological
imbalances
alter
the
diversity
composition
gut
microbiota.
While
evidence
suggests
EDs
can
arise
from
epigenetic
aberrations,
alterations
microbial
communities
may
also
contribute
to
development
and/or
persistence
through
mechanisms.
Understanding
interplay
among
communities,
processes,
risk
provides
opportunities
for
designing
preventive
therapeutic
interventions
microbiome
modulation.
This
review
highlights
how
microbiome-based
therapeutics
specific
dietary
improving
various
subtypes
modulating
mitigating
aberrations.
First,
we
briefly
literature
on
links
between
aberrations
pathophysiology
EDs.
Second,
examine
potential
role
pathogenesis
Next,
explore
associations
other
psychiatric
disorders,
roles
their
pathogenesis.
Finally,
present
supporting
improve
modifications.
Язык: Английский
Study on the ameliorative effect of marine fungus Hansfordia sinuosae extracellular polysaccharide on DSS-induced ulcerative colitis and depression-like behavior
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142852 - 142852
Опубликована: Апрель 1, 2025
Язык: Английский
The gut microbiota-brain connection: insights into major depressive disorder and bipolar disorder
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 5, 2024
Major
depressive
disorder
(MDD)
and
bipolar
(BD)
are
two
of
the
most
prevalent
mood
disorders
that
seriously
jeopardize
both
physical
mental
health.
The
current
diagnosis
MDD
BD
relies
primarily
on
clinical
symptoms.
However,
correctly
differentiating
between
during
episode
states
remains
a
substantial
challenge.
human
gut
hosts
large
diverse
microbiota,
which
plays
pivotal
role
in
various
physiological
processes.
Emerging
evidence
suggests
microbiota
(GM)
exerts
beneficial
effects
health
disorders,
including
MDD,
BD,
schizophrenia,
through
microbe-gut-brain
axis
(MGBA).
In
recent
years,
relationship
GM
has
garnered
considerable
attention,
leading
to
intensive
research
this
area.
MGBA
is
bidirectional
communication
system
brain.
Growing
indicates
brain
can
influence
GM,
turn
may
modulate
axis.
This
review
aims
explore
changes
patients
with
evaluate
different
treatments
their
medication,
probiotic,
prebiotic
synbiotic
interventions,
fecal
transplantation
(FMT).
By
doing
so,
we
seek
identify
potential
disease-specific
biomarkers,
improve
differential
diagnosis,
offer
novel
therapeutic
avenues
for
these
disorders.
Язык: Английский
Gut microbiota biodiversity indices as markers of hyperandrogenemia in women of reproductive age
Acta Biomedica Scientifica (East Siberian Biomedical Journal),
Год журнала:
2024,
Номер
9(4), С. 12 - 18
Опубликована: Сен. 25, 2024
Introduction.
Pr
eviously
,
it
was
shown
that
the
“classic”
phenotypes
of
polycystic
ovarian
syndrome
(PCOS)
are
associated
with
significant
decrease
in
gut
microbiota
alpha
diversity
as
compared
healthy
women.
The
aim
study.
T
o
establish
cut-off
points
for
indices,
hyperandrogenism.
Material
and
methods.
he
manuscript
pr
esents
a
sub-study
Eastern
Siberia
PCOS
Epidemiology
Phenotype
Study,
conducted
(Russia)
from
2016
to
2019.
All
participants
(175
women
reproductive
age:
26
(according
Rotterdam
criteria
(2003))
hyperandrogenemia
(increased
levels
total
testosterone
(TT)
and/or
free
androgenindex(FAI),
and/ordehydroepiandrosterone
sulphate
(DHEAS)),
149
–
without
hyperandrogenemia)
were
recruited
during
annual
employment
medical
assessment.
Methods
included
questionnaire
survey,
anthropometry
modified
Ferriman
Gallwey
score,
gynecological
examination,
pelvic
ultrasound,
blood
serum
tests
TT,
DHEAS,
sex
hormone-binding
globulin,
FAI,
prolactin,
thyroid-stimulating
hormone,
17-hydroxyprogesterone.
Five
indices
(amplicon
sequencing
variant,
Shannon
index,
Simpson
Chao
abundance-based
coverage
Index)
estimated
using
amplicon
metasequencing.
Statistical
analysis
ROC-analysis
development
hyperandrogenism
age
PCOS.
Results
.
According
t
results
ROC-analysis,
greatest
sensitivity
moderate
specificity,
high
area
under
curve
established
classifying
or
5.84
0.97,
respectively.
Conclusions.
developed
assessing
most
can
be
useful
monitoring
different
therapeutic
interventions
(prebiotics,
probiotics,
etc.)
hyperandrogenic
Язык: Английский