Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway DOI Creative Commons

Clóvis Colpani Filho,

Lucas Melfior,

S. Ramos

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 151 - 151

Опубликована: Фев. 3, 2025

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, along with restricted repetitive patterns of behavior, interests, or activities. ASD encompasses wide spectrum clinical presentations functional impairments, ranging from mild to severe. Despite its prevalence, the underlying physiopathological mechanisms remain largely unknown, resulting lack effective targeted therapeutic interventions, contributing significant financial emotional burdens on affected families healthcare system. Emerging evidence suggests that dysfunction tetrahydrobiopterin (BH4) pathway may impair activity monoaminergic nitric oxide (NO)-dependent neurons individuals ASD. To explore this potential mechanism, we conducted systematic review analyze such impairments gather information whether off-label use BH4 could represent novel pharmacological approach for managing Following PRISMA 2020 guidelines, systematically reviewed literature four databases: PubMed, Virtual Health Library, Cochrane SciELO, January 1967 December 2021. The quality included studies was assessed using Newcastle–Ottawa scale. inclusion criteria focused identifying articles published English contained following keywords, used various combinations: autism, ASD, autism disorder, BH4, tetrahydrobiopterin, neopterin, NO, oxide. analysis performed between collected data demonstrated metabolism altered Lower levels were reported biological samples ASD-affected compared age- sex-matched controls. Additionally, neopterin elevated plasma urine, but decreased cerebrospinal fluid, while consistently be higher across studies. Treatment has shown improving ASD-related symptoms. increase fluids indicates inflammation, reduction shift metabolic role. Specifically, diverted primary role neurotransmitter synthesis function as an antioxidant perpetuate inflammation through NO production. Given critical cofactor neurotransmission, highlights molecule’s potential. already FDA-approved other conditions, emerges promising candidate alleviate symptomatology.

Язык: Английский

Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway DOI Creative Commons

Clóvis Colpani Filho,

Lucas Melfior,

S. Ramos

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 151 - 151

Опубликована: Фев. 3, 2025

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, along with restricted repetitive patterns of behavior, interests, or activities. ASD encompasses wide spectrum clinical presentations functional impairments, ranging from mild to severe. Despite its prevalence, the underlying physiopathological mechanisms remain largely unknown, resulting lack effective targeted therapeutic interventions, contributing significant financial emotional burdens on affected families healthcare system. Emerging evidence suggests that dysfunction tetrahydrobiopterin (BH4) pathway may impair activity monoaminergic nitric oxide (NO)-dependent neurons individuals ASD. To explore this potential mechanism, we conducted systematic review analyze such impairments gather information whether off-label use BH4 could represent novel pharmacological approach for managing Following PRISMA 2020 guidelines, systematically reviewed literature four databases: PubMed, Virtual Health Library, Cochrane SciELO, January 1967 December 2021. The quality included studies was assessed using Newcastle–Ottawa scale. inclusion criteria focused identifying articles published English contained following keywords, used various combinations: autism, ASD, autism disorder, BH4, tetrahydrobiopterin, neopterin, NO, oxide. analysis performed between collected data demonstrated metabolism altered Lower levels were reported biological samples ASD-affected compared age- sex-matched controls. Additionally, neopterin elevated plasma urine, but decreased cerebrospinal fluid, while consistently be higher across studies. Treatment has shown improving ASD-related symptoms. increase fluids indicates inflammation, reduction shift metabolic role. Specifically, diverted primary role neurotransmitter synthesis function as an antioxidant perpetuate inflammation through NO production. Given critical cofactor neurotransmission, highlights molecule’s potential. already FDA-approved other conditions, emerges promising candidate alleviate symptomatology.

Язык: Английский

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