Criteria to Report Adverse Drug Withdrawal Events in Clinical Trials: A Systematic Review

Journal of the American Geriatrics Society, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

ABSTRACT Background Polypharmacy is a major risk factor for adverse drug events (ADEs), which are common cause of hospitalization, especially among older adults. Deprescribing promising strategy to prevent ADEs; however, clinicians may hesitate deprescribe fear causing withdrawal (ADWEs). Collectively, ADWEs the re‐emergence symptoms or disease state due discontinuation medication. Although capturing critical understanding complications that might arise from deprescribing, these not be routinely systematically captured in clinical trials. Objectives We aimed determine frequency ADWE reporting, compare strengths and limitations different approaches, rates number detected across Methods A systematic review was performed following Preferred Reporting Items Systematic Reviews Meta‐Analyses checklist. The search developed with research librarian, studies were identified using Ovid Medline, Embase, Cochrane Central Register Controlled Trials inception July 2, 2024. included all randomized controlled trials testing deprescribing intervention adults (mean median age ≥ 65 years) analyzed subsample reporting as an outcome. Results Among 139 eligible identified, only 12 reported ADWE. These utilized 6 approaches capture ADWEs: Naranjo Probability Scale; monitoring specific symptoms; identification through ICD‐10 codes; subset confirmed patient/caregiver self‐report; judgment. Conclusion few there lack standardized reporting. harmonized approach criteria could ensure more consistent results trials, improve our this important outcome, facilitate future meta‐analyses.

Язык: Английский

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The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis

Supportive Care in Cancer, Год журнала: 2023, Номер 31(5)

Опубликована: Апрель 25, 2023

Язык: Английский

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Flexipill: A Novel 3D Printed Personalised Analgesic Polypill with Diverse Targeted Drug Release Approaches.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106882 - 106882

Опубликована: Апрель 1, 2025

Язык: Английский

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Polypharmacy and Elevated Risk of Severe Adverse Events in Older Adults Based on the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database

Journal of Korean Medical Science, Год журнала: 2024, Номер 39(28)

Опубликована: Янв. 1, 2024

Older adults are at a higher risk of severe adverse drug events (ADEs) because multimorbidity, polypharmacy, and lower physiological function. This study aimed to determine whether defined as the use ≥ 5 active ingredients, was associated with ADEs in this population. We used ADE reports from Korea Institute Drug Safety Risk Management-Korea Adverse Event Reporting System Database, national spontaneous report system, 2012 2021 examine compare strength association between polypharmacy older (≥ 65 years) younger (20-64 using disproportionality analysis. found significant cardiac renal/urinary Medical Dictionary for Regulatory Activities Organ Classes (MedDRA SOC) adults. Regarding individual-level included these MedDRA SOCs, acute arrest renal failure were more significantly compared The addition new drugs regimens warrants close monitoring symptoms.

Язык: Английский

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Medicines use and polypharmacy in retirement village residents in Aotearoa New Zealand: a point prevalence observational study

Journal of Primary Health Care, Год журнала: 2024, Номер 16(4), С. 407 - 411

Опубликована: Май 6, 2024

Introduction Polypharmacy increases the risk of medicines-related harm, including falls, in older adults. Falls have a significant impact on quality life and health system resources. Little is known about medicine use retirement village (RV) residents Aotearoa New Zealand (NZ). Aim Our study aimed to describe point prevalence polypharmacy among cohort RV Auckland, NZ. Methods Data collection occurred from July 2016 June 2018. Eligible participants (those residing permanently RV) were recruited RVs Zealand. Medicines data collected using an interRAI assessment tool. Descriptive statistics, t-tests Chi-squared tests used for analysis. Results A total 578 33 median age was 81.6 years. Participants took mean 4.8 regular medicines (standard deviation = 2.9) 0.7 ‘as required’ medicines. Anti-hypertensives (68.5%), lipid-lowering (45.2%), antacids (39.4%) antiplatelet agents (37.9%) most prescribed classes. (five-plus medicines; 51.8%) common hyperpolypharmacy (10-plus 5.7%) infrequently. Discussion This provides insight into by primary secondary prevention cardiovascular disease commonly common. Active review residents’ warranted, based these findings increasing evidence regarding medicines, those disease. Trial registration Australia Clinical Trials Registry: CTRN12616000685415. Registered 25.5.2016. Universal Number (UTN): U111–1173-6083.

Язык: Английский

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Pharmacists’ attitudes towards interprofessional collaboration to optimise medication use in older patients in Switzerland: a survey study

BMC Health Services Research, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 26, 2024

Abstract Background Collaboration between physicians and pharmacists facilitates the conduct of medication optimisation efforts. In context deprescribing, pharmacists’ roles are often described as making deprescribing recommendations to physicians. Little is known about factors associated with willingness make their interprofessional collaboration in Swiss primary care settings. Objective To explore pharmacists' perspectives on older adults, preferences for Methods this cross-sectional study, a random sample 1000 pharmacist members Pharmacists Association pharmaSuisse was invited participate survey optimisation, collaboration. The contained three case vignettes multimorbid patients polypharmacy aged ≥ 80 years old, different levels dependency activities daily living (ADL) cardiovascular disease (CVD). For each vignette, were asked if which medications they would deprescribe. We calculated proportions deprescribe by vignette performed multilevel logistic regression assess associations CVD, ADL, Results One hundred thirty-eight (14%) responded survey: 113 (82%) female, mean age 44 ( SD = 11), 66% n 77) reported having never received any specific training how structured reviews. Eighty-three (72%) be confident identifying opportunities. All willing 1 all vignettes. Patients CVD at lower odds deprescribed (OR 0.27, 95%CI 0.21 0.36). Willingness higher ADL (medium versus low dependency: OR 0.68, 0.54 0.87, high 0.72, 0.56 0.91). However, effect significantly modified history CVD. five (97%) interact clarify questions regarding prescriptions least once week 88 (81%) wished more involved review. Conclusion suggestions polypharmacy, but two-thirds no formal perform like process review should leveraged

Язык: Английский

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The association between continuous polypharmacy and hospitalization, emergency department visits, and death in older adults: a nationwide large cohort study

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 31, 2024

This study aimed to investigate the association between continuous polypharmacy and hospitalization, emergency department (ED) visits, death.

Язык: Английский

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Epidemiologic Analysis of Drug and Poison Information Center (DPIC) Inquiries: A Four-Year Cross-Sectional Study in Hamadan, Iran (2019-2023)

Journal of Pharmaceutical Care, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Background: Drug and Poison Information Centers (DPIC) play a pivotal role in pharmacovigilance, public education, preventing adverse drug reactions, medication errors, poisoning incidents. Methods: This study presents an epidemiologic analysis of inquiries received by the DPIC at Hamadan University Medical Sciences Iran over four years (2019-2023). A descriptive cross-sectional recorded phone calls to from October 2019 November 2023. The demographic distribution inquirers, types inquiries, sources used answer questions were considered analysis. Results: reports total 3904 four-year period, with average 78.08 per month. majority callers female (61%). top three focused on coronavirus, side effects, drug-drug reactions. Psychiatric agents, gastrointestinal antibiotics families inquired about. data collected various references, UptoDate® being most frequently (43.3%). Conclusion: provides comprehensive Sciences. findings underscore importance DPICs providing evidence-based information, contributing enhancing patient safety.

Язык: Английский

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Association between number of medications and indicators of potentially inappropriate polypharmacy: a population-based cohort of older adults in Quebec, Canada

Therapeutic Advances in Drug Safety, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

As the number of medications increases, appropriateness polypharmacy may become questionable due to heightened risk medication-related harm.

Язык: Английский

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Exploring Polypharmacy and Drug Interactions in Geriatric Patients: A Cross-Sectional Study from India

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 16, 2024

Background Polypharmacy and potential drug-drug interactions (pDDIs) present challenges in managing elderly individuals with multiple comorbidities. Understanding their prevalence associated factors is vital for enhancing medication safety therapeutic outcomes. Objective This study aimed to assess the of polypharmacy pDDIs among aged 60 years above at Yenepoya Medical College Hospital. Methods A prospective observational was conducted hospital's in-patient out-patient wards following ethics committee approval. Patient records were reviewed, prescriptions screened using Medscape UpToDate. SPSS 26.0 analyzed data identify patterns characterize pDDIs. Results Predominantly older adults participated (mean age approximately 70.25 years), notable prevalence, especially in-patients. Gender disparities evident, females receiving more medications on average (p = 0.036). Moderate (50%) most common various severity levels. Age correlated positively (r 0.897) prescribed medications, but categories showed no significant association drug > 0.05). However, a relationship existed between quantity interaction 4.77e-05). Conclusion The highlights individuals, emphasizing management. We found polypharmacy, particularly complex health conditions, observed pervasive nature moderate interactions.

Язык: Английский

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