Malaria vaccination: hurdles to reach high-risk children

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 13, 2024

Abstract Ensuring that malaria vaccines deliver maximum public health impact is non-trivial. Drawing on current research, this article examines hurdles immunization may face to reach high-risk children and explores the policy implications. The analysis finds system related risks with potential reduce ability of provide equitable protection. Deployment effective frameworks tackle these so as strengthen within-country equity progress tracking should be entangled deployment vaccines. To capture more comprehensively disease- system-related child survival, vaccine allocation criteria expand their data indicator breadth. Factoring molecular, clinical, epidemiological features antimalarial drug resistance into critical effectively reflect future control interventions. It proposed approximately 6–15 would need vaccinated prevent a adverse outcome. Vaccine purchasing delivery costs overwhelm endemic countries’ systems given sizeable number needed vaccinate, population at-risk children, limited government financing sector. Innovations in are pivotal ensuring cost-effectiveness sustainability programs aiming attain maintain universal

Язык: Английский

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Childhood Vaccine Hesitancy as an Interaction‐Based Phenomenon

Sociology of Health & Illness, Год журнала: 2025, Номер 47(4)

Опубликована: Апрель 12, 2025

The paper discusses the role of interaction between parents and healthcare professionals in overcoming or heightening childhood vaccine hesitancy. Childhood hesitancy is seen as a set attitudes behaviours-that is, dispositions-that are highly dependent on how trust vulnerability intersect during vaccination appointments. Drawing rapid team ethnography conducted Northwest Italy, we discuss parents' changes along specific trajectories, depending manage epistemic conflicts with hesitant parents. We employ concept interactional to show can be eroded restored interactions, regardless initial capital. Healthcare professionals' discursive interactive strategies inoculation have long-term effects interpersonal institutional both immunisation system. If fail embrace their reciprocal vulnerability, building system flawed.

Язык: Английский

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Pertussis Epidemiology in Children: The Role of Maternal Immunization

Vaccines, Год журнала: 2024, Номер 12(9), С. 1030 - 1030

Опубликована: Сен. 9, 2024

In the last twelve months, a significant global increase in pertussis cases has been observed, particularly among infants under three months of age. This age group is at highest risk for severe disease, hospitalization, and death. Maternal immunization with Tdap vaccine during pregnancy recommended to protect newborns by transferring maternal antibodies transplacentally. review examines current epidemiology pertussis, importance preventing it young children, effectiveness immunization. Despite proven benefits vaccination, which found effective prevention up 90% cases, coverage remains suboptimal many countries. Factors contributing low vaccination rates include hesitancy due trust health authority assessments, safety concerns, practical barriers access, impact COVID-19 pandemic, disrupted routine services. The recent may also be influenced natural cyclic nature increased Bordetella (Bp) activity older children adults, genetic divergence circulating Bp strains from antigens. Given high efficacy infants, increasing crucial. Efforts improve uptake should address access hesitancy, ensuring consistent immune protection youngest most vulnerable populations. Enhanced could significantly reduce incidence whooping cough decreasing related hospitalizations deaths.

Язык: Английский

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Validation of a questionnaire for evaluating vaccine literacy in adulthood vaccination: A pilot study from Zhejiang province, China

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Фев. 19, 2025

This study aimed to validate a tool for assessing vaccine literacy (VL) in adult vaccination under the Chinese context. A pilot on adult's VL was conducted 2023 Huzhou city of Zhejiang province, China. self-designed questionnaire, specific self-assessment three domains (functional, interactive, and critical), as well knowledge acceptance applied. Validation process questionnaire through investigation panel experts, principal component analysis (factors whose cumulative explanation proportion variance > 80% were selected) Cronbach's α coefficient test (>0.7 acceptable). Correlation domains, also implemented, r value its significance calculated. For validation mean scores reliability, comprehensibility, efficiency, sensitivity each question functional interactive/critical ranged from 3.86 (sensitivity VL) 4.26 (comprehensibility VL). 0.8223 with VL, 0.8916 interactive 0.9061 critical VL. The 3.36, 3.06 2.91, respectively. score 5.80. positive response rate receiving influenza vaccine, pneumococcal herpes-zoster 36.5% (73/200), 23.00% (46/200) 11.66% (19/163). all individual's significantly correlated high education degree (r = 0.37 0.35 0.30 0.28 knowledge, 0.42 acceptance). shown be valid reliable measuring among adults. It recommended that should validated larger more diverse samples, exploring impact interventions improve relationship between behavior over time.

Язык: Английский

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Increasing confidence for pediatric COVID-19 and influenza vaccines using messages affirming parental autonomy: A randomized online experiment

Vaccine, Год журнала: 2025, Номер 53, С. 126947 - 126947

Опубликована: Март 2, 2025

Язык: Английский

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Understanding attitudes and beliefs regarding COVID-19 vaccines among transitional-aged youth with mental health concerns: a youth-led qualitative study

BMJ Open, Год журнала: 2024, Номер 14(1), С. e080707 - e080707

Опубликована: Янв. 1, 2024

Background Transitional-aged youth (16–29 years) with mental health concerns have experienced a disproportionate burden of the COVID-19 pandemic. Vaccination is limited in this population; however, determinants its vaccine hesitancy are not yet thoroughly characterised. Objectives This study aimed to answer following research question: What beliefs and attitudes illness about vaccines, how do these perspectives affect acceptance? The aims generate findings inform development resources specific concerns. Methods A qualitative methodology engagement focus was used conduct in-depth semistructured interviews transitional-aged aged 16–29 years one or more self-reported diagnoses Mental encompassed wide range symptoms diagnoses, including mood disorders, anxiety neurodevelopmental disorders personality disorders. Participants were recruited from seven main clinical support networks across Canada. Transcripts 46 6 family member analysed using thematic analysis. Results Two major themes generated: (1) factors affecting trust vaccines (2) influences safety considerations decision-making. Subthemes included healthcare providers, government mistreatment towards racialised populations, direct indirect health. Conclusions Our analysis suggests lived experiences affected decision-making related that can be targeted increase uptake. provide new insights into among concerns, which highly relevant ongoing vaccination efforts for strains as well other transmissible diseases future pandemics. Next steps include cocreating youth-specific public encourage population.

Язык: Английский

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Assessing the Impact of the COVID-19 Pandemic on Pregnant Women’s Attitudes towards Childhood Vaccinations: A Cross-Sectional Study

Vaccines, Год журнала: 2024, Номер 12(5), С. 473 - 473

Опубликована: Апрель 29, 2024

The COVID-19 pandemic has globally disrupted immunisation practices, impacting vulnerable populations such as pregnant women (PW), who harbour concerns about future children’s immunisations. This study aimed to assess the pandemic’s impact on PW’s attitudes towards childhood vaccinations. During three consecutive flu seasons from October 2019 January 2022, a cross-sectional was conducted in large Italian teaching hospital using questionnaire. chi-square test performed compare each season. Across 2019–2020 2021–2022 seasons, course attendance by PW surged 105 340. Significant shifts vaccination intentions were noted, including 7.5% decrease measles intent (p = 0.02) and 10% that of pertussis 0.004) 2020–2021. While perceived contagion risk decreased, disease severity perceptions increased, with few significant differences. A statistically reduction noted proportion participants suspecting economic motives behind NHS workers’ promotion Furthermore, period saw an increase utility non-institutional websites advice physicians outside NHS. These findings will help develop evidence-based, tailored interventions communication strategies address vaccine hesitancy ensure optimal coverage among children born during after pandemic.

Язык: Английский

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Socioeconomic determinants and reasons for non-acceptance to vaccination recommendations during the 3rd - 5th waves of the COVID-19 pandemic in Hungary

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 5, 2024

Abstract Background In Hungary, although six types of vaccines were widely available, the percentage people receiving primary series COVID-19 vaccination remained below EU average. This paper investigates reasons for Hungary’s lower coverage by exploring changing attitudes towards vaccination, socio-demographic determinants, and individual non-acceptance during 3 rd - 5 th pandemic waves COVID-19. Methods The study’s empirical analysis is based on representative surveys conducted in Hungary between February 19, 2021, June 30, 2022. study used a total 17 surveys, each with sample size at least 1000 respondents. Binomial logistic regression models to investigate which characteristics are most likely influence vaccine hesitancy Hungary. analysed 2506 open-ended responses identify non-acceptance. categorised into four main categories 13 sub-categories. Results Between third fifth wave pandemic, have significantly changed. Although proportion vaccinated individuals has increased steadily, who reported not accepting almost unchanged. Socio-demographic an important determinant observed hesitancy, they relatively stable over time. Individuals younger age groups those socioeconomic status more decline while living capital city likely. A significant reason behind refusal can undoubtedly be identified as lack trust (specifically distrust science), facing information barrier perception low personal risk. Conclusion compulsory childhood particularly high voluntary adult vaccines, such influenza less well accepted. Vaccine acceptance heavily affected social-demographic people. Mistrust about if managed, easily affect people’s opinion other well. Identifying understanding complexity how evolved help understand halt both general confidence developing targeted public health programs address these issues.

Язык: Английский

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Validation of an Arabic tool for assessing vaccination literacy: A factor and Rasch analysis

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Июль 22, 2024

Vaccine literacy is a significant part of health literacy. Although several tools have been developed to assess vaccine literacy, such are lacking in Arabic. Validating an Arabic version tool that evaluates critically important, as it would aid understanding the decision-making process regarding vaccinations among individuals Arabic-speaking countries. Therefore, current study aimed validate for assessing adult vaccination. An online questionnaire was distributed people throughout Jordan by sharing link via various social media platforms. The reliability and validity vaccination assessment (HLVa-Ar) were evaluated using factor analysis Rasch analyses. two-factor model generated fit indices acceptable range (χ2/df = 2.48, RMSEA 0.06, SRMR 0.05, GFI 0.94, CFI 0.97, TLI 0.96). Cronbach's alpha functional Vaccination (VL) interactive/critical VL 0.91 0.88 respectively. indicated infit/outfit values high item person separation reliabilities two factors (0.852, 0.868, 0.771, 0.818 respectively). Overall, 420 participants displayed good general benefits importance HLVa-Ar shown be valid reliable portrayed wide levels studied sample provided valuable insights into participants' knowledge. findings emphasize need developing targeted strategies improve increase rates.

Язык: Английский

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A systematic approach to microbial forensics

Journal of Medical Microbiology, Год журнала: 2024, Номер 73(2)

Опубликована: Фев. 2, 2024

The coronavirus disease 2019 pandemic accelerated developments in biotechnology that underpin infection science. These advances present an opportunity to refresh the microbial forensic toolkit. Integration of novel analytical techniques with established methods will speed up acquisition evidence and better support lines enquiry. A critical part any such investigation is demonstration a robust causal relationship attribution responsibility for incident. In wider context formal into agency, motivation intent, quick efficient assembly microbiological sets tone tempo entire investigation. from science systematic approach forensics therefore ensure major perspectives are correctly used frame shape clear narrative, while recognizing hypothesis generation, testing refinement comprise iterative process. Development multidisciplinary training exercises use this enable translation practice implementation when need arises.

Язык: Английский

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