Associations of dietary inflammation index and composite dietary antioxidant index with all-cause mortality in COPD patients

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 21, 2025

Background Few studies have investigated the effects of both dietary inflammatory index (DII) and composite antioxidant (CDAI) on mortality in patients with Chronic Obstructive Pulmonary Disease (COPD). Our research aimed to explore associations between two indicators all-cause COPD patients. Methods We conducted a prospective cohort analysis based data from six cycles National Health Nutrition Examination Survey (NHANES) dataset 2007 2018. Multivariate Cox proportional hazard models were used analyze DII CDAI COPD. employed restricted cubic spline (RCS) examine dose–response relationship mortality, threshold effect determine inflection point, subgroup interaction tests verify stability results. Results A total 1,457 aged over 40 enrolled study. The median follow-up time was 76.8 months. multivariate hazards model showed that increased associated an increase (HR (95% CI): 1.11(1.04, 1.18), p = 0.002). In contrast, negatively correlated 0.95(0.91, 0.99), 0.01). RCS nonlinear correlation or mortality. maximum pro-inflammatory point 2.32, while is −0.12. Subgroup analyses indicated exposure variables stable most populations. Conclusion Reducing diet increasing can reduce

Язык: Английский

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Association of sleep duration and sleep disorders with post-stroke depression and all-cause and cardiovascular disease mortality in US stroke survivors: results from NHANES 2005–2018

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 3, 2025

Sleep disturbance is a common concern among stroke survivors, yet the association of sleep duration and disorders with post-stroke depression all-cause cardiovascular disease (CVD) mortality remains elusive. We aimed to explore these associations using data from National Health Nutrition Examination Survey (NHANES). Adult survivors NHANES 2005–2018 were included. information diagnoses derived self-reports on relevant questionnaires. Mortality collected by prospectively matching Death Index. Multivariate logistic regression Cox proportional hazards used calculate odds ratio (OR) hazard (HR), respectively. A total 1101 participants In fully adjusted model, associated increased (OR 2.689, p = 0.0146). was inversely depression; compared normal duration, short 2.196, 0.0059), whereas long not (p 0.1435). CVD (HR 1.948, 0.026) but 0.224) in survivors. positively 1.075, 0.042); however, neither nor duration. Restricted cubic spline modeling suggested that nonlinearly linearly mortality, Age influenced between depression, These findings underscore achieving improving may reduce mortality.

Язык: Английский

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The association between visceral fat metabolic score and stroke: mediation by declining kidney function

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 8, 2025

Stroke is a leading cause of mortality and disability worldwide. Metabolic Score for Visceral Fat (METS-VF), metric visceral obesity, has emerged as novel predictor metabolic diseases. However, its association with stroke remains unclear. This study investigates the relationship between METS-VF risk stroke, well potential mediating role kidney function. Data from 1999-2020 National Health Nutrition Examination Survey (NHANES) were analyzed, including 19,109 participants. Weighted logistic regression models used to assess risk, restricted cubic splines employed explore their non-linear relationships. Mediation analysis examined function, measured by estimated glomerular filtration rate (eGFR). Subgroup sensitivity analyses, propensity score matching (PSM) multiple imputations, conducted ensure robustness findings. Higher was significantly associated an increased (OR = 2.78, 95% CI: 1.71-4.52, P < 0.001) after adjusting covariates. A observed, sharply increasing when exceeded 7.00. revealed that declining eGFR mediated 26.72% METS-VF-stroke association. indicated stronger in men 5.06, 2.80-9.12, than women 2.01, 1.03-3.92, 0.04, interaction 0.01). Sensitivity analyses using PSM imputations confirmed results. independently showing relationship,

Язык: Английский

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Predicting Cardiovascular Disease and All-Cause Mortality Using the Lymphocyte-to-Monocyte Ratio: Insights from Explainable Machine Learning Models

International Journal of Cardiology Cardiovascular Risk and Prevention, Год журнала: 2025, Номер unknown, С. 200372 - 200372

Опубликована: Янв. 1, 2025

Язык: Английский

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Association between triglyceride glucose-waist height ratio and stroke: a population-based study

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 12, 2025

Background Stroke poses a substantial threat to global public health. The triglyceride glucose-waist height ratio (TyG-WHtR), which incorporates the TyG metric with obesity-related WHtR, has demonstrated superior diagnostic and predictive value compared index alone. Nevertheless, there is still lack of in-depth exploration into relationship between TyG-WHtR stroke. This study seeks address this gap by extracting information from National Health Nutrition Examination Survey (NHANES) elucidate potential association levels Methods included 8,757 individuals four research cycles conducted 2011 2018. To examine stroke, we multivariable logistic regression analysis. In addition, smooth curve fitting was applied display nonlinear association. Subgroup analyses sensitivity contributed examining robustness consistency receiver operating characteristic (ROC) curves were employed evaluate capability TyG. Results After adjusting for relevant covariates, positive stroke occurrence observed (OR: 1.26, 95% CI: 1.02-1.55). Specifically, each unit increase in associated 26% higher likelihood findings analysis further stability relationship. revealed that significant among participants who did not engage moderate exercise those without coronary heart disease or angina pectoris. ROC exhibited Conclusion identified an elevated increased prevalence suggesting may serve as valuable tool risk, implications clinical prevention early intervention.

Язык: Английский

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Association between pan-immune-inflammation value and dyslipidemia in the United States population

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

To investigate the possible association between pan-immune-inflammation value (PIV) and dyslipidemia. This cross-sectional study used data obtained from National Health Nutrition Examination Survey (NHANES). The independent variable logarithmic form of PIV-log2 (PIV). definition dyslipidemia was based on Cholesterol Education Program standards. Weighted multivariate logistic regression analyses, restricted cubic spline (RCS) threshold effect analysis were explore PIV Stratified analyses to identify potential associations with other covariates. receiver operating characteristic (ROC) curve constructed compared systemic immune-inflammation index (SII). 6,821 participants included, whom 47% male 77% had After adjusting for all confounders, an significantly positive (OR (95%CI): 1.13 (1.01-1.25); P = 0.03). Compared lowest quartile (Q1) PIV, highest (Q4) a higher risk 1.37 (1.05-1.80); 0.022). RCS showed inverted J-shaped relationship (P-nonlinear 0.0415, P-overall < 0.001). revealed that inflection point 9.192. age BMI modified PIV-dyslipidemia (P interaction 0.05). ROC found SII, similar predictive (area under (AUC): 0.566 vs 0.558; 0.073). discovered dyslipidemia, especially in young overweight individuals.

Язык: Английский

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Flavonoid intake, inflammation, and atherosclerotic cardiovascular disease risk in U.S. adults: a cross-sectional study

Nutrition & Metabolism, Год журнала: 2025, Номер 22(1)

Опубликована: Март 18, 2025

This study aimed to investigate the relationship between dietary intake of total flavonoids and their six subclasses risk atherosclerotic cardiovascular disease (ASCVD) in adults, evaluate potential mediating effect inflammation this association. Cross-sectional data from 3841 individuals participating National Health Nutrition Examination Survey 2017–2018 were included analysis. Flavonoid was assessed using a 2-day recall method, ASCVD status determined by extracting relevant information medical condition questionnaire. To determine flavonoid risk, we employed logistic regression, subgroup, mediation, restricted cubic spline analyses. Intake flavan-3-ols, flavones, flavonols, negatively correlated with risk. Subgroup analysis revealed that association exhibits sex-specific differences, being more pronounced among women. The significant associations increased reduced observed smokers, non-alcohol consumers, physically inactive individuals, those hypertension. A nonlinear flavonoids, flavan-3-ols flavonols Additionally, high-sensitivity C-reactive protein (hs-CRP) neutrophil-to-lymphocyte ratio (NLR), inflammatory markers ASCVD, found mediate Flavonoids demonstrated dose‒response reductions levels hs-CRP NLR. indicates inverse intake, particularly ASCVD. It highlights role CRP NLR relationship. Furthermore, emphasizes importance considering lifestyle factors sex when evaluating benefits flavonoids.

Язык: Английский

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Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018

Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Янв. 3, 2025

Stroke is a significant cerebrovascular disease and remains one of the leading causes death disability worldwide. Insulin resistance has been strongly linked to incidence stroke. Employing characteristics metabolic syndrome, Metabolic Score for Resistance (METS-IR) accurately measures insulin resistance. Nonetheless, relationship between METS-IR stroke risk not well-established. We analyzed data from National Health Nutrition Examination Survey (NHANES) covering years 2007-2018. Participants providing complete self-reported information were included in study. utilized weighted multivariate regression explore stroke, performing subgroup analyses as well. A total 14,794 participants included, with an average 43.44 ± 12.68. The overall prevalence was 3.79%, higher rates observed upper tertiles. An increase unit associated 1% (OR = 1.01; 95% CI: 1.01-1.02). Interaction tests indicated no effects gender, smoking status, alcohol consumption, hypertension, diabetes, physical activity, or serum cholesterol levels on this relationship. Notably, younger than 60 years, association significantly stronger 1.02; 1.01-1.03), marked interaction (p 0.0061). Our findings indicate positive correlation increased risk. Early intervention targeting may be viable preventive measure against particularly individuals under age.

Язык: Английский

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A comprehensive analysis of stroke risk factors and development of a predictive model using machine learning approaches

Molecular Genetics and Genomics, Год журнала: 2025, Номер 300(1)

Опубликована: Янв. 24, 2025

Stroke is a leading cause of death and disability globally, particularly in China. Identifying risk factors for stroke at an early stage critical to improving patient outcomes reducing the overall disease burden. However, complexity requires advanced approaches accurate prediction. The objective this study identify key develop predictive model using machine learning techniques enhance detection improve clinical decision-making. Data from China Health Retirement Longitudinal Study (2011–2020) were analyzed, classifying participants based on baseline characteristics. We evaluated correlations among 12 chronic diseases applied algorithms stroke-associated parameters. A dose–response relationship between these parameters was assessed restricted cubic splines with Cox proportional hazards models. refined model, incorporating age, sex, factors, developed. patients significantly older (average age 69.03 years) had higher proportion women (53%) compared non-stroke individuals. Additionally, more likely reside rural areas, be unmarried, smoke, suffer various diseases. While correlated (p < 0.05), correlation coefficients generally weak (r 0.5). Machine identified nine associated risk: TyG-WC, WHtR, TyG-BMI, TyG, TMO, CysC, CREA, SBP, HDL-C. Of these, SBP exhibited positive risk. In contrast, TMO HDL-C reduced fully adjusted elevated CysC (HR = 2.606, 95% CI 1.869–3.635), CREA 1.819, 1.240–2.668), 1.008, 1.003–1.012) increased risk, while 0.989, 0.984–0.995) 0.99995, 0.99994–0.99997) protective. nomogram demonstrated superior accuracy, Harrell's C-index individual predictors. This identifies several significant presents that can high-risk Among them, WHtR positively whereas opposite. serves as valuable decision-support resource clinicians, facilitating effective prevention treatment strategies, ultimately outcomes.

Язык: Английский

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The Dietary Inflammatory Index and Sarcopenia in Older Adults in Four Chinese Provinces: A Cross-Sectional Study

Nutrients, Год журнала: 2025, Номер 17(3), С. 478 - 478

Опубликована: Янв. 28, 2025

Background: Sarcopenia associated with aging severely affects the quality of life elderly; diets have been shown to elicit an inflammatory response in body, and that promote inflammation may lead damage muscles. The Dietary Inflammatory Index (DII) has developed quantify potential individual diets. Therefore, this study aimed investigate association between DII, sarcopenia its components elderly Chinese people. Methods: In study, data were obtained from China Nutrition Improvement Strategies Applications for Elderly Research Programme. An assessment was carried out according Asian Working Group on Sarcopenia’s (AWGS2019) criteria. DII calculated using food intake FFQ method, then quartile method used categorize subjects into four groups. Multifactor logistic regression conducted examine associations components. Results: This included 993 over age 65, prevalence 20.2%. mean score population 0.99 ± 0.1. After adjusting confounders age, gender, marital status, educational level, risk 1.66 times higher group Q4 than Q1 (p-trend < 0.05). However, relationship is not statistically significant when other more confounding factors are added. Nevertheless, further analyzing components, it found after model, a muscle strength loss (OR = 1.65, p-trend Conclusions: Higher scores increase older adults. By guiding adults adopt anti-inflammatory diet, health can be improved terms increased strength. Further cohort or interventional studies necessary validate our findings.

Язык: Английский

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