Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan DOI Creative Commons
Rie Kanamori, Nozomi Aoki,

Akio Kanazawa

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 10, 2024

Background As the life expectancy of people living with human immunodeficiency virus (HIV) (PLWH) has improved, chronic disease burden and polypharmacy have increased in PLWH. Simplification antiretroviral therapy (ART) regimen for PLWH become crucial. The real-world treatment patterns medication persistence 2-drug single-tablet (STR), dolutegravir/lamivudine (DTG/3TC), compared to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) prescribed were investigated. Methods This retrospective, database study extracted data from a hospital-based medical claims Japan. changes ART distributions by year during identification period between January 1, 2018 December 31, 2021 observed. Patients record HIV-1 infection DTG/3TC or BIC/FTC/TAF as first prescription STR divided into two cohorts; cohort cohort, respectively. Patient without records more than 3 months no future 6 excluded. Patients’ characteristics Mantel–Haenszel test adjust age. Medication was cohorts evaluating continuation rates using Kaplan–Meier methods, log-rank assess difference curves. median time-to-first methods. Results Prescriptions steadily 2019 after release each STR. There significant ( p = 0.3). A total 959 patients included, 120 839 on BIC/FTC/TAF, proportion dyslipidemia at baseline significantly higher adjusting mean age 0.002). 0.91). Conclusion showed that likely be selected elderly those clinical practice, which seems accordance strategy recommended guidelines. Comparable observed both regimens, aligning findings other countries. may an important multiple morbidities aging society. Due limitations database, further research viral loads, emergence resistance adverse events will encouraged.

Язык: Английский

Antiretroviral therapy adherence among people living with HIV in Vietnam using a multi-method tool: A cross-sectional study DOI Creative Commons
L. Vo,

Dung Quoc Phan,

Bang Van Khanh Quang

и другие.

Asian Pacific Journal of Tropical Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
Characteristics and real-world medication persistence of people living with HIV treated with DTG/3TC or BIC/FTC/TAF: a hospital claims database study in Japan DOI Creative Commons
Rie Kanamori, Nozomi Aoki,

Akio Kanazawa

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 10, 2024

Background As the life expectancy of people living with human immunodeficiency virus (HIV) (PLWH) has improved, chronic disease burden and polypharmacy have increased in PLWH. Simplification antiretroviral therapy (ART) regimen for PLWH become crucial. The real-world treatment patterns medication persistence 2-drug single-tablet (STR), dolutegravir/lamivudine (DTG/3TC), compared to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) prescribed were investigated. Methods This retrospective, database study extracted data from a hospital-based medical claims Japan. changes ART distributions by year during identification period between January 1, 2018 December 31, 2021 observed. Patients record HIV-1 infection DTG/3TC or BIC/FTC/TAF as first prescription STR divided into two cohorts; cohort cohort, respectively. Patient without records more than 3 months no future 6 excluded. Patients’ characteristics Mantel–Haenszel test adjust age. Medication was cohorts evaluating continuation rates using Kaplan–Meier methods, log-rank assess difference curves. median time-to-first methods. Results Prescriptions steadily 2019 after release each STR. There significant ( p = 0.3). A total 959 patients included, 120 839 on BIC/FTC/TAF, proportion dyslipidemia at baseline significantly higher adjusting mean age 0.002). 0.91). Conclusion showed that likely be selected elderly those clinical practice, which seems accordance strategy recommended guidelines. Comparable observed both regimens, aligning findings other countries. may an important multiple morbidities aging society. Due limitations database, further research viral loads, emergence resistance adverse events will encouraged.

Язык: Английский

Процитировано

0