Social participation patterns and associations with subsequent cognitive function in older adults with cognitive impairment: a latent class analysis

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 27, 2025

Social participation (SP) has been associated with cognitive benefits among older adults; however, little is known about SP patterns and their relationships function in cognitively impaired populations. This study aimed to identify individuals evaluate associations subsequent function, specifically mental intactness episodic memory. Data were drawn from the China Health Retirement Longitudinal Study (CHARLS), including 5,673 aged 60 years impairment 2015 2018. Latent class analysis (LCA) was used patterns, hierarchical linear regression analyses conducted examine between these function. Four distinct identified: "Offline Participation Group" (Class 1), "Intellectual Only 2), "Club Volunteer Activities 3), "Minimal 4). The Class 4 comprised majority (73%) exhibited poorest outcomes. Compared 4, 2 showed significant improvements (p < 0.001) memory = 0.022), while 3 demonstrated 0.032) but not 1 0.023). highlights of social participation, particularly intellectual activities, for adults impairment. Targeted interventions promoting SP, especially are essential mitigate decline improve resilience vulnerable

Язык: Английский

The nonlinear association of ratio of total cholesterol to high density lipoprotein with cognition ability: evidence from a community cohort in China

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 5, 2025

Cholesterol is a critical component of the human body, particularly within brain, where it plays an essential role in maintaining cellular structure and function. In addition, blood lipid profile has been recognized as significant factor influencing cognitive performance. However, association between ratio total cholesterol (TC) to high-density lipoprotein (HDL-C) function remains unclear. This community-based, cross-sectional study was conducted using data from middle-aged older adults (aged ≥45 years) participating China Health Retirement Longitudinal Study (CHARLS). The primary exposure interest TC HDL-C, while main outcome function, assessed cognition scores. TC-HDL-C performance examined multiple linear regression analyses restricted cubic spline modeling assess potential nonlinear relationships. A 8,914 participants were included analysis. Within certain range, higher significantly associated with improved scores (p < 0.05) among adults. relationship remained even after adjusting for sociodemographic health-related factors. Moreover, revealed nonlinearity <0.05) Subgroup further highlighted differential effects across specific population subgroups. Sensitivity consistently supported robustness observed Our findings confirm elderly individuals, These results underscore importance appropriate support health aging populations.

Язык: Английский

Dyslipidemia and cerebral atrophy among health check-up individuals: a cross-sectional study

International Journal of Cardiology Cardiovascular Risk and Prevention, Год журнала: 2025, Номер 25, С. 200394 - 200394

Опубликована: Март 8, 2025

To examine the association between dyslipidemia and cerebral atrophy in Chinese health check-up population. 67,526 participants underwent routine check-ups at management center of First Affiliated Hospital Sun Yat-Sen University (FAH-SYSU) Guangzhou for two years (2022-2023) this cross-sectional study. Cerebral was determined by expert physicians based on non-contrast scans Head Magnetic Resonance Imaging (MRI), Angiography (MRA) and/or Computed Tomography (CT). The levels Total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C) triglyceride (TG) were measured classified quartiles into four categories, respectively. multivariable logistic regression model used to obtain odds ratios (ORs) 95% confidence intervals (CIs). A total 1,661 included with ages from 18 93 years. Among participants, 121 (7.28%) had atrophy. On multivariate analysis, TC LDL-C not associated atrophy, although lower subgroup This study conducted China is first identify that examinees raising possible cognitive dysfunction. Future planned overcome existing limitation address lack statistically significant dementia.

Язык: Английский