Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

ABSTRACT Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide, imposing a substantial global burden. However, its pathogenesis remains incompletely understood, and effective treatment strategies are still lacking. Organoid technology, in which stem cells or progenitor self‐organise into miniature tissue structures under three‐dimensional (3D) culture conditions, provides promising vitro platform for simulating pathological microenvironment of OA. This approach can be employed to investigate mechanisms, carry out high‐throughput drug screening facilitate personalised therapies. review summarises structure, OA manifestations, thereby establishing context application organoid technology. It then examines components arthrosis system, specifically addressing cartilage, subchondral bone, synovium, skeletal muscle ligament organoids. Furthermore, it details various constructing organoids, including considerations cell selection, classification fabrication techniques. Notably, this introduces concept intelligent manufacturing organoids by incorporating emerging engineering technologies such as artificial intelligence (AI) process, forming an innovative software hardware cluster. Lastly, discusses challenges currently facing highlights future directions rapidly evolving field. By offering comprehensive overview state‐of‐the‐art methodologies challenges, anticipates that intelligent, automated will expedite fundamental research, discovery translational applications orthopaedic

Язык: Английский

Standardization and consensus in the development and application of bone organoids

Theranostics, Год журнала: 2024, Номер 15(2), С. 682 - 706

Опубликована: Дек. 2, 2024

Organoids, self-organized structures derived from stem cells cultured in a specific three-dimensional (3D) vitro microenvironment, have emerged as innovative platforms that closely mimic vivo cellular behavior, tissue architecture, and organ function. Bone organoids, frontier organoid research, can replicate the complex functional characteristics of bone tissue. Recent advancements led to successful development including models callus, woven bone, cartilage, trabecular marrow. These organoids are widely utilized establishing bone-related disease models, injury repair, drug screening. However, significant discrepancies remain between current human skeletal tissues terms morphology functionality, limiting their ability accurately model physiology pathology. To address these challenges promote standardization construction, evaluation, application we convened experts research teams with substantial expertise field. By integrating existing findings, this consortium aims establish consensus guide future organoids.

Язык: Английский

Future challenges in the surgical treatment of breast cancer – Oncoplastic, prophylactic procedures and reconstructive surgery

Senologie - Zeitschrift für Mammadiagnostik und -therapie, Год журнала: 2024, Номер 21(03), С. 227 - 237

Опубликована: Сен. 1, 2024

Abstract Medical knowledge is doubling faster and faster. Surgeons are highly specialized must be trained not only in surgery, but also imaging oncology to meet the modern requirements of a breast center. This article describes what has changed surgical treatment cancer over past 20 years since introduction certified centers Germany, could change future. Pre- post-operative conferences have become central component interdisciplinary exchange information. Every breast-conserving operation precisely planned, marked carried out controlled manner. Basic anatomical sufficient enough perform prophylactic mastectomy. Implant-based reconstructions their shape strength time usually lead follow-up operations. Tissue engineering offers interesting approaches replace disadvantages conventional implants order achieve durability quality similar autologous tissue reconstructions.

Язык: Английский