Adipose Tissue Hyperplasia and Hypertrophy in Common and Syndromic Obesity—The Case of BBS Obesity

Nutrients, Год журнала: 2023, Номер 15(15), С. 3445 - 3445

Опубликована: Авг. 4, 2023

Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue depends on interplay between hyperplasia and hypertrophy, mainly regulated complex interaction genetics excess energy intake. However, genetic regulation yet to be fully understood. can divided into common multifactorial/polygenic obesity monogenic obesity, non-syndromic syndromic. Several genes related were found through studies models. syndromic characterized additional features other than suggesting more global role mutant syndrome and, thus, an peripheral influence development hardly studied date in this regard. This review summarizes present knowledge regarding hypertrophy adipocytes obesity. Additionally, we highlight scarce research as model for studying adipocyte focusing Bardet–Biedl (BBS). BBS involves central mechanisms, with molecular mechanistic alternation hypertrophy. Thus, argue that using models, such BBS, further advance our

Язык: Английский

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Pharmacogenetic interactions of medications administered for weight loss in adults: a systematic review and meta-analysis

Pharmacogenomics, Год журнала: 2023, Номер 24(5), С. 283 - 295

Опубликована: Март 31, 2023

To analyze roles of single nucleotide variants (SNVs) on weight loss with US FDA-approved medications.

Язык: Английский

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Ghrelin Suppresses Apoptosis and Autophagy in Osteoarthritis Synovial Cells by Modulating the ADORA2B/PI3K/Akt/mTOR Signaling Pathway

Journal of Orthopaedics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The importance of CYP1B1 polymorphism in obesity

Medicine, Год журнала: 2025, Номер 104(19), С. e42378 - e42378

Опубликована: Май 9, 2025

Obesity is a multifactorial disease, commonly observed both worldwide and in our country, triggered by environmental genetic factors, adversely affecting all physiological functions of the body, leading to an increase body fat mass. Although various variants associated with susceptibility obesity have been identified genomic studies, these explain only small portion basis obesity. This case-control study investigates, for first time Turkish population, relationship between CYP1B1 gene rs1056827 rs1056836 polymorphisms patients undergoing surgical intervention (bariatric surgery). Genotyping was performed using Real-Time PCR 63 female 29 male who underwent bariatric surgery 40 51 nonobese individuals. In study, genotype distributions polymorphism were found be 51.1% CC, 40.2% CG, 8.7% GG case group 46.2% 47.3% 6.6% control group. The frequency C allele 71.2%, G 28.8% group, while 70.3%, 29.7% For polymorphism, 10.8% GG, 35.9% GT, 53.3% TT 7.7% 49.4% 42.9% 28.8%, T 71.2% whereas 32.4%, 67.6% No significant difference groups terms anthropometric measurements biochemical parameter values gene. Our valuable as it investigate association CYP1B1*2 (rs1056827) CYP1B1*3 (rs1056836) obesity, determined that there no investigated

Язык: Английский

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The rs17782313 polymorphism near MC4R gene confers a high risk of obesity and hyperglycemia, while PGC1α rs8192678 polymorphism is weakly correlated with glucometabolic disorder: a systematic review and meta-analysis

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Авг. 9, 2023

Background The relationships of the rs17782313 polymorphism near melanocortin 4 receptor gene (MC4R) and rs8192678 in peroxisome proliferator-activated gamma coactivator 1 alpha (PGC1α) with metabolic abnormalities have been explored many populations around world, but findings were not all consistent sometimes even a bit contradictory. Methods Electronic databases including Medline, Scopus, Embase, Web Science, CNKI Google Scholar checked for studies that met inclusion criteria. Data carefully extracted from eligible studies. Standardized mean differences (SMDs) calculated by using random-effects model to examine indexes obesity, glucometabolic disorder dyslipidemia between genotypes polymorphisms. Cochran’s Q-statistic test Begg’s employed identify heterogeneity among publication bias, respectively. Results Fifty (58,716 subjects) 51 (18,660 respectively included pooled meta-analyses C-allele carriers had higher average level body mass index (SMD = 0.21 kg/m 2 , 95% confidence interval [95% CI] 0.12 0.29 p < 0.001), waist circumference 0.14 cm, CI 0.06 0.23 0.001) blood glucose 0.09 mg/dL, 0.02 0.16 0.01) than TT homozygotes. Regarding polymorphism, no significant associations detected. However, correlations multiple observed subgroup analyses stratified sex, age, ethnicity health status. Conclusion meta-analysis demonstrates C allele MC4R confers risk obesity hyperglycemia, PGC1α is weakly correlated disorder. These may partly explain these variants diabetes as well cardiovascular disease. Systematic review registration https://www.crd.york.ac.uk/prospero/ identifier CRD42022373543.

Язык: Английский

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Alterations in GLP-1 and PYY release with aging and body mass in the human gut

Molecular and Cellular Endocrinology, Год журнала: 2023, Номер 578, С. 112072 - 112072

Опубликована: Сен. 21, 2023

The lining of our intestinal surface contains an array hormone-producing cells that are collectively bodies' largest endocrine cell reservoir. These "enteroendocrine" (EE) reside amongst the billions absorptive epithelial and other types line gastrointestinal tract can sense respond to ever-changing internal environment in gut. EE release important signalling molecules act as hormones, including glucagon-like peptide (GLP-1) YY (PYY) which co-secreted from L cells. While much is known about effects these hormones on metabolism, insulin secretion food intake, less understood their human tissue. In this study we assess whether GLP-1 PYY differs across small large tissue locations within tract, and/or by sex, body weight age individual. We identify both greater more distal regions colon, but not different between sexes. observe a negative correlation BMI small, large, intestine. Increased aging correlates with declining When data for intestine isolated region, relationship remains significant ascending descending colon PYY. This first demonstration site-specific differences occur gut, do relationships mass.

Язык: Английский

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Predisposition of the Common MC4R rs17782313 Female Carriers to Elevated Obesity and Interaction with Eating Habits

Genes, Год журнала: 2023, Номер 14(11), С. 1996 - 1996

Опубликована: Окт. 25, 2023

The global rise in obesity is attributed to genetic predisposition interaction with an obesogenic environment. Melanocortin 4 receptor (MC4R) rs17782313 polymorphism has been linked common varying influence across different populations. MC4R a crucial player the leptin proopiomelanocortin pathway that regulates weight hemostasis. We aimed study and its eating behaviors on Israeli population. Adults’ (n = 5785, >18 y) genotype anthropometric demographic data were analyzed using logistic regression models adjusting for age, sex, T1DM, T2DM. significantly predisposes elevated risk under recessive additive (OR 1.38, 95% CI: 1.1–1.72, p 0.005 OR 1.1, 1.01–1.2, 0.03, respectively) adjusted confounders (age, T2DM). Stratification by sex demonstrated carrying associated model among females only 1.41, 1.09–1.82, 0.01), average of 0.85 BMI increment compared wild type one allele carriers. interacted several enhance obesity. Our findings demonstrate homozygous female carriers are predisposed amplified behaviors.

Язык: Английский

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Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 28, 2024

Introduction Appetitive traits are influenced by the interplay between genetic and environmental factors. This study aimed to explore relationship gene polymorphisms involved in regulation of energy balance food reward appetitive young Mexican subjects. Methods cross-sectional 118 university freshman undergraduates who completed Adult Eating Behaviour Questionnaire for Spanish speakers (AEBQ-Esp) assess their traits. A real-time PCR system was employed determine ( LEP rs7799039, MC4R rs17782313, FTO rs9939609, GHRL rs696217), DRD2/ANKK1 Taq1A rs1800497 COMT rs4680). Results The mean age participants 20.14 ± 3.95 years, 71.2% were women BMI 23.52 4.05 kg/m 2 . Met allele carriers presented a significantly higher “Emotional overeating” score than Val (2.63 0.70 vs. 2.23 0.70, p = 0.028). CC + CT genotype correlated positively with (Phi 0.308, 0.01). MetMet+MetVal r 0.257, 0.028; Phi 0.249, 0.033). protective TT undereating” 0.298, 0.012). Carriers risk (OR 2.4, 95% CI 1.3–4.8, 0.034). 3.4, 1.1–10.3, 0.033), associated ValVal carriers. 1.8, 1.1–9.1, 0.014). Discussion found genotypes Met/Met+Met/Val overeating.” These factors may increase weight gain enhancing hedonic consumption reducing satiety control. Future studies should focus on replication ethnically diverse adults life stages weight. will help tailor personalized nutrigenetic strategies counteract disordered eating patterns leading obesity co-morbidities.

Язык: Английский

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Association of MC4R rs17782313 Genotype With Energy Intake and Appetite: A Systematic Review and Meta-analysis

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract Context The melanocortin-4 receptor gene (MC4R) is associated with a higher risk of obesity by the presence C allele in rs17782313, but mechanisms are not clear. Objective present systematic review and meta-analysis aimed to explore association between different genotypes MC4R rs17782313 energy intake appetite. Data Sources A literature search was conducted up June 2023 PubMed, Scopus, Web Science, Cochrane Collaboration databases, following PRISMA guidelines. Extraction Inclusion criteria were studies humans measuring intake, appetite, or satiety all ages physiological conditions. Studies dealing solely body mass index excluded. Twenty-one articles representing 48 560 participants included meta-analysis. Analysis According NHLBI (National Heart, Lung, Blood Institute) quality-assessment criteria, case-control 6 out 17 cohort cross-sectional classified as “good,” while rest scored “fair.” Odds ratios (ORs) 95% confidence intervals (CIs) calculated (CT+CC) vs TT dominant model, both random-effects fixed-effects models used. statistically significant increased appetite found (OR = 1.25; CI: 1.01–1.49; P .038) using model proved nonsignificant. However, no found. None variables considered (sample size, year publication, sex, age group, type population, origin, quality) identified effect modifiers, publication biases after subgroup meta-regression analyses. Conclusion To our knowledge, this first that has analyzed Identifying people genetically predisposed may be great interest, only prevent younger populations also avoid malnutrition elderly persons. This paper part Nutrition Reviews Special Collection on Precision . Systematic Review Registration PROSPERO registration no. CRD42023417916.

Язык: Английский

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The interaction between the Circadian Locomotor Output Cycles Kaput and Melanocortin-4-receptor gene variants on obesity and parameters related to obesity

Clinical Nutrition, Год журнала: 2024, Номер 45, С. 193 - 201

Опубликована: Дек. 24, 2024

Язык: Английский

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