Unveiling the Etiology of Osteoporosis Onset: A Mendelian Randomization Investigation DOI Creative Commons
Wei Yang, Peng Yang, Miao Cui

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Abstract Objective Osteoporosis (OP) is a prevalent systemic metabolic disorder characterized by reduction in total bone mass and deterioration of microarchitecture. These changes result significantly increased fragility, which predisposes patients to higher risk fractures. As consequence, OP severely impacts patients' quality life imposes considerable economic burden on society. With the ongoing global demographic shift towards an aging population, it crucial gain deeper understanding pathogenesis develop effective therapeutic strategies. This study aims identify potential causal factors associated with examining genetic variations, goal providing new insights for prevention management disease. Methods We commenced our investigation developing comprehensive search protocol. Subsequently, we conducted systematic across several Chinese databases, including China National Knowledge Infrastructure (CNKI), Biomedical Literature Database (CBM), Wanfang Database, VIP Information (CSTJ), as well international databases such The Cochrane Library, PubMed, Embase, Web Science. thorough was executed electronically ensure complete collection most current literature data related OP, thereby minimizing oversights. Following this, established rigorous inclusion exclusion criteria selection, followed meticulous review synthesis existing literature. process enabled us accurately range etiological OP. To substantiate association between these disease, incorporated extensive outcome from Finnish database, included 3,203 cases 209,575 controls, UK Biobank comprised 5,266 331,893 controls.The robust datasets enhances statistical rigor reliability findings. employed two-sample bidirectional Mendelian randomization(MR) approach, utilizing variation instrumental variable. method mitigates influence confounding reverse causality, thus enabling more exploration relationship hypothesized risk. assess heterogeneity results, applied Cochran's Q test MR-Egger MR-PRESSO regression techniques investigate pleiotropy. homogeneity research guard against pleiotropy, calculated impact quantification index (ORSD) each factor's effect varying degrees variation. calculation offers substantial evidence disease's etiology. Furthermore, rigorously control accuracy outcomes, implemented False Discovery Rate (FDR) correction Bonferroni methods. approaches mitigate false positives multiple hypothesis testing, preserving scientific integrity credibility conclusions. Results Through analysis, identified database. Notably, primary biliary cholangitis, type 1 diabetes, seropositive rheumatoid arthritis, seronegative arthritis exhibited positive correlations In contrast, 2 diabetes demonstrated inverse condition. Biochemical indicators, Dickkopf-related protein sex hormone-binding globulin levels, were positively Socioeconomic factors, education levels years schooling, showed negative Lifestyle habits, drinking frequency, biochemical indicators like oxalate also displayed associations. specific population characteristics, relative body size 10-year-old male children, along physical systolic blood pressure, inversely risk.In data, menopausal status, celiac irritable bowel syndrome, lupus erythematosus, level, environmental exposures PM2.5 Conversely, age, dietary non-oily fish consumption, pulse pressure found be negatively Post-hoc corrections employing revealed significant age Biobank. application correction, database indicated additional associations levels. confirmed have Biobank, remained consistent. Conclusion findings, derived perspective, effectively exclude certain previously implicated pathogenic while highlighting others. distinction pivotal implications are profound, valuable that could inform development preventive strategies

Язык: Английский

Association between a body shape index and bone mineral density in US adults based on NHANES data DOI Creative Commons
J. Wu, Yu‐Cheng Gu

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 22, 2025

The relationship between a body shape index (ABSI) and bone mineral density (BMD) remains uncertain, prompting further investigation. This study aims to elucidate the association ABSI BMD using data from 2011–2018 National Health Nutrition Examination Survey (NHANES), involving participants aged 20–60. was calculated formula: = 1000 × waist circumference (m)×weight (kg)−2/3×height (m)5/6. analysis employed weighted multiple linear regression, smooth curve fitting, stratified analysis, interaction tests explore total BMD. included 10,291 participants, with mean age of 39.11 ± 10.77 years, 49.20% were women. average 80.21 1.50. Total BMD, thoracic spine lumbar pelvis measured, values 0.82 0.11 g/cm², 1.03 0.15 1.24 0.16 g/cm2, respectively. A negative correlation observed. In fully adjusted model, individuals in highest quartile had levels 0.045 g/cm² lower than those lowest quartile. Interaction showed consistent across subgroups, variations sex BMI. NHANES confirms persistent suggesting that could be useful osteoporosis prevention diagnosis.

Язык: Английский

Процитировано

1
Impact of Central Obesity on Bone Mineral Density Across Life Stages: A Genetic Epidemiology and Cross-Sectional Study DOI Creative Commons

Camilo Alberto Pinzon Galvis,

yuhong jiang,

Xianhao Huang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract Introduction: This study aimed to investigate the association and causality between central obesity bone mineral density (BMD). Methods We utilized linkage disequilibrium score regression (LDSC) Mendelian randomization (MR) assess genetic correlations causal relationships waist circumference adjusted for BMI (WCadjBMI) total body less head BMD (TB-BMD). Additionally, a cross-sectional analysis of 7,452 participants evaluated relationship A shape index (ABSI) TB-BMD using weighted multivariable linear smooth curve fitting. Results LDSC MR confirmed negative WCadjBMI (β=-0.16; 95% CI: -0.26, -0.07). The indicated that an increase 0.01 ABSI corresponded decrease 0.035 (g/cm2), with this effect being particularly pronounced in males older adults. An inflection point was identified at = 0.076: below threshold, positively correlated pelvis BMD, whereas above it, became negative. Conclusions Central is significantly negatively related BMD. Maintaining within 0.058–0.078 crucial individuals mass accrual (20–30 years) stabilization (30–45 periods. In contrast, managing people experiencing early loss (45–60 presents greater complexity warrants further investigation.

Язык: Английский

Процитировано

0
Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005–2018 DOI Creative Commons

Z. Wang,

Guo-Liang Ma,

Bo Xu

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

Despite accumulating evidence on central obesity and osteoporosis, the role of a body shape index (ABSI), nonlinear quantifying via mass (BMI), waist circumference (WC), height, remains controversial underexplored. Although recent meta-analyses suggest may modulate fracture risk bidirectionally, no research has comprehensively compared ABSI with traditional adiposity metrics, such as BMI, WC, waist-to-height ratio (WHtR), to predict site-specific changes in bone mineral density (BMD) across anatomical regions. This study utilized National Health Nutrition Examination Survey (NHANES) data from 2005 2018, involving 12,421 participants. was computed using formula: = WC/(BMI²/³ × Height¹/²). BMD assessed at four sites-the total femur (TF), femoral neck (FN), trochanter (TR), intertrochanter (IN) regions-via dual-energy X-ray absorptiometry (DXA). The association between analyzed multiple regression models generalized additive model (GAM). To compare ABSI's predictive efficacy conventional indices, analyses juxtaposed against WHtR assessing correlations BMD. After full covariate adjustment, significant negative observed regions (P< 0.01). Smoothed curve fitting revealed relationship threshold effect among middle-aged older individuals. Additionally, an inverted J-shaped all Meanwhile, showed associations sites (β -0.27 -0.31, p-trend< 0.000001), whereas exhibited positive (WHtR showing strongest effect: β 0.41-0.69). highlights ability detect adiposity-related loss obscured by metrics. robust inverse -0.31), persisting analyses, establish it novel biomarker skeletal fragility. Unlike indices reflecting mechanical loading benefits (BMI 0.008-0.012; WC 0.003-0.005; 0.41-0.69), specifically captures visceral fat-driven metabolic disorder-a critical pathway for osteoporosis stratification normal-weight obese populations.

Язык: Английский

Процитировано

0
Association between cardiometabolic index and bone mineral density among adolescents in the United States DOI Creative Commons
Haobiao Liu, Rongqi Xiang,

Chenyue Liu

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Май 8, 2025

The cardiometabolic index (CMI) serves as a comprehensive metric for evaluating health, and is correlated with several health outcomes. However, research examining the relationship between CMI bone mineral density (BMD), particularly in adolescent populations, remains limited warrants further investigation. weighted multiple linear regression analysis was conducted to elucidate association BMD. Our study ultimately included 1,514 participants. After adjusting pertinent covariates, we observed that per-unit increases corresponded reductions BMD by 0.052 g/cm2 femoral neck (β=-0.052, 95% CI: -0.087 -0.018) 0.048 lumbar spine (L1-L4) (β=-0.048, -0.085 -0.011). In quartile analyses, individuals highest displayed significantly reduced at (β=-0.036, -0.064 -0.007) (β=-0.041, -0.070 -0.011) compared those lowest (P<0.05). No statistical significance detected total femur, trochanter, intertrochanter sites. Furthermore, stratified analyses indicated no significant interactions involving age, sex, or race relation population, inversely related These findings highlight potential link health. Future longitudinal investigations are warranted determine causal relationships underlying mechanisms.

Язык: Английский

Процитировано

0
Association between new anthropometric indices and osteoporosis in Chinese postmenopausal women- retrospective study based on hospitalized patients in China DOI Creative Commons
Xin Zhao, Jianbin Sun, S. H. Xin

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Май 16, 2025

Objective This study aimed to investigate the correlation between new anthropometric indicators and osteoporosis in postmenopausal women, evaluate whether these can be used for screening of provide evidence prevention fractures patients. Methods retrospectively analyzed 470 females hospitalized Department Endocrinology Peking University International Hospital January 2017 August 2022. According bone mineral density (BMD) results, subjects were divided into two groups: normal group group. Results (1) Compared with group, women OP older, levels BMD lower, 25(OH)D all differences being statistically significant (p&lt;0.05). The body shape index (ABSI), Chinese visceral fat (CVAI), abdominal volume (AVI), roundness (BRI) significantly higher, mass (BMI) was lower Osteoporosis (OP) than (all p&lt;0.05). (2) CVAI negatively correlated hip lumbar spine (r=-0.35, p&lt;0.05; r=-0.20, BRI (r=-0.37, (3) After adjusting age, blood pressure (BP), glucose, lipids, estimated Glomerular Filtration Rate (eGFR) Ca levels, high CVAI, AVI independent risk factors (OR=4.27, 95%CI 2.49, 7.33; OR=2.08, 1.23, 3.51; OR=6.11, 95% CI 3.39, 11.01). (4) model predicting using showed that AUCs ranked &gt; ABSI = BMI lipid accumulation (LAP) waist-to-hip ratio (WHR) waist-to-height (WHtR). Conclusion clinical are associated women. It is necessary pay attention BRI, AVI, other which also great significance osteoporosis.

Язык: Английский

Процитировано

0
Unveiling the Etiology of Osteoporosis Onset: A Mendelian Randomization Investigation DOI Creative Commons
Wei Yang, Peng Yang, Miao Cui

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Abstract Objective Osteoporosis (OP) is a prevalent systemic metabolic disorder characterized by reduction in total bone mass and deterioration of microarchitecture. These changes result significantly increased fragility, which predisposes patients to higher risk fractures. As consequence, OP severely impacts patients' quality life imposes considerable economic burden on society. With the ongoing global demographic shift towards an aging population, it crucial gain deeper understanding pathogenesis develop effective therapeutic strategies. This study aims identify potential causal factors associated with examining genetic variations, goal providing new insights for prevention management disease. Methods We commenced our investigation developing comprehensive search protocol. Subsequently, we conducted systematic across several Chinese databases, including China National Knowledge Infrastructure (CNKI), Biomedical Literature Database (CBM), Wanfang Database, VIP Information (CSTJ), as well international databases such The Cochrane Library, PubMed, Embase, Web Science. thorough was executed electronically ensure complete collection most current literature data related OP, thereby minimizing oversights. Following this, established rigorous inclusion exclusion criteria selection, followed meticulous review synthesis existing literature. process enabled us accurately range etiological OP. To substantiate association between these disease, incorporated extensive outcome from Finnish database, included 3,203 cases 209,575 controls, UK Biobank comprised 5,266 331,893 controls.The robust datasets enhances statistical rigor reliability findings. employed two-sample bidirectional Mendelian randomization(MR) approach, utilizing variation instrumental variable. method mitigates influence confounding reverse causality, thus enabling more exploration relationship hypothesized risk. assess heterogeneity results, applied Cochran's Q test MR-Egger MR-PRESSO regression techniques investigate pleiotropy. homogeneity research guard against pleiotropy, calculated impact quantification index (ORSD) each factor's effect varying degrees variation. calculation offers substantial evidence disease's etiology. Furthermore, rigorously control accuracy outcomes, implemented False Discovery Rate (FDR) correction Bonferroni methods. approaches mitigate false positives multiple hypothesis testing, preserving scientific integrity credibility conclusions. Results Through analysis, identified database. Notably, primary biliary cholangitis, type 1 diabetes, seropositive rheumatoid arthritis, seronegative arthritis exhibited positive correlations In contrast, 2 diabetes demonstrated inverse condition. Biochemical indicators, Dickkopf-related protein sex hormone-binding globulin levels, were positively Socioeconomic factors, education levels years schooling, showed negative Lifestyle habits, drinking frequency, biochemical indicators like oxalate also displayed associations. specific population characteristics, relative body size 10-year-old male children, along physical systolic blood pressure, inversely risk.In data, menopausal status, celiac irritable bowel syndrome, lupus erythematosus, level, environmental exposures PM2.5 Conversely, age, dietary non-oily fish consumption, pulse pressure found be negatively Post-hoc corrections employing revealed significant age Biobank. application correction, database indicated additional associations levels. confirmed have Biobank, remained consistent. Conclusion findings, derived perspective, effectively exclude certain previously implicated pathogenic while highlighting others. distinction pivotal implications are profound, valuable that could inform development preventive strategies

Язык: Английский

Процитировано

0