International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7299 - 7299
Опубликована: Июль 2, 2024
Diabetes
mellitus
(DM)
poses
a
significant
challenge
to
global
health,
with
its
prevalence
projected
rise
dramatically
by
2045.
This
narrative
review
explores
the
bidirectional
relationship
between
periodontitis
(PD)
and
type
1
diabetes
(T1DM),
focusing
on
cellular
molecular
mechanisms
derived
from
interplay
oral
microbiota
host
immune
response.
A
comprehensive
search
of
studies
published
2008
2023
was
conducted
elucidate
association
these
two
diseases.
Preclinical
clinical
evidence
suggests
relationship,
individuals
T1DM
exhibiting
heightened
susceptibility
periodontitis,
vice
versa.
The
includes
recent
findings
human
studies,
revealing
variations
in
composition
patients,
including
increases
certain
pathogenic
species
such
as
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 16, 2023
Diabetes
mellitus
is
a
main
risk
factor
for
periodontitis,
but
until
now,
the
underlying
molecular
mechanisms
remain
unclear.
can
increase
pathogenicity
of
periodontal
microbiota
and
inflammatory/host
immune
response
periodontium.
Hyperglycemia
induces
reactive
oxygen
species
(ROS)
production
enhances
oxidative
stress
(OS),
exacerbating
tissue
destruction.
Furthermore,
alveolar
bone
resorption
damage
epigenetic
changes
in
induced
by
diabetes
may
also
contribute
to
periodontitis.
We
will
review
latest
clinical
data
on
evidence
promoting
susceptibility
periodontitis
from
epidemiological,
mechanistic,
potential
therapeutic
targets
discuss
possible
mechanistic
targets,
focusing
particular
novel
OS.
Understanding
intertwined
pathogenesis
explain
cross-interference
between
endocrine
metabolic
inflammatory
diseases
better,
provide
theoretical
basis
new
systemic
holistic
treatment,
promote
interprofessional
collaboration
physicians
dentists.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 4, 2024
Abstract
Periodontitis
is
a
chronic
inflammatory
disease
caused
by
the
local
microbiome
and
host
immune
response,
resulting
in
periodontal
structure
damage
even
tooth
loss.
Scaling
root
planning
combined
with
antibiotics
are
conventional
means
of
nonsurgical
treatment
periodontitis,
but
they
insufficient
to
fully
heal
periodontitis
due
intractable
bacterial
attachment
drug
resistance.
Novel
effective
therapeutic
options
clinical
therapy
remain
scarce.
Nanotherapeutics
achieve
stable
cell
targeting,
oral
retention
smart
release
great
flexibility
changing
chemical
composition
or
physical
characteristics
nanoparticles.
Meanwhile,
protectiveness
high
surface
area
volume
ratio
nanoparticles
enable
loading,
ensuring
remarkable
efficacy.
Currently,
combination
advanced
novel
strategies
most
active
research
treatment.
In
this
review,
we
first
introduce
pathogenesis
then
summarize
state-of-the-art
nanotherapeutic
based
on
triple
concerto
antibacterial
activity,
immunomodulation
periodontium
regeneration,
particularly
focusing
mechanism
ingenious
design
nanomedicines.
Finally,
challenges
prospects
nano
for
discussed
from
perspective
current
problems
future
development
trends.
Graphical
Pathogens,
Год журнала:
2022,
Номер
11(10), С. 1173 - 1173
Опубликована: Окт. 11, 2022
Porphyromonas
gingivalis
is
a
gram-negative,
anaerobic
bacterium
that
lives
in
the
oral
cavity.
It
an
integral
part
of
microbiome,
which
includes
more
than
500
types
bacteria.
Under
certain
circumstances,
as
consequence
virulence
factors,
it
can
become
very
destructive
and
proliferate
to
many
cells
periodontal
lesions.
one
causative
agents
present
extremely
often
dental
plaque
main
etiological
factor
development
disease.
During
various
therapeutic
procedures,
P.
enter
blood
disseminate
through
distant
organs.
This
primarily
refers
influence
on
subacute
endocarditis
facilitate
coronary
heart
disease,
atherosclerosis,
ischemic
infarction.
The
action
facilitated
by
numerous
factors
pathogenicity
such
fimbriae,
hemolysin,
hemagglutinin,
capsules,
outer
membrane
vesicles,
lipopolysaccharides,
gingipains.
A
special
problem
possibility
biofilm
formation.
1000
times
less
sensitive
antimicrobial
drugs
planktonic
cells,
represents
significant
treatment
infections
caused
this
pathogen.
Biomedicines,
Год журнала:
2022,
Номер
10(1), С. 178 - 178
Опубликована: Янв. 16, 2022
Periodontitis
and
diabetes
are
two
major
global
health
problems
despite
their
prevalence
being
significantly
underreported
underestimated.
Both
epidemiological
intervention
studies
show
a
bidirectional
relationship
between
periodontitis
diabetes.
The
hypothesis
of
potential
causal
link
the
diseases
is
corroborated
by
recent
in
experimental
animals
that
identified
mechanisms
whereby
can
adversely
affect
each
other.
Herein,
we
will
review
clinical
data
on
existence
two-way
discuss
possible
mechanistic
interactions
both
directions,
focusing
particular
new
highlighting
importance
host
response.
Moreover,
address
trained
immunity
may
represent
unifying
mechanism
explaining
intertwined
association
periodontitis.
Achieving
better
insight
clustering
infectious,
inflammatory,
metabolic
provide
therapeutic
options
to
reduce
risk
diabetes-associated
comorbidities.
Nutrients,
Год журнала:
2023,
Номер
15(9), С. 2115 - 2115
Опубликована: Апрель 28, 2023
The
mode
and
mechanism
of
diabetic
periodontitis-induced
alveolar-osteocyte
death
are
still
unclear.
This
study
aimed
to
investigate
the
occurrence
ferroptosis
in
alveolar
osteocytes
during
periodontitis
therapeutic
potential
resveratrol
alleviate
osteocyte
ferroptosis.
Diabetic
was
induced
C57/BL6-male
mice
treated
with
or
without
resveratrol.
Periodontitis
pathogenicity
analyzed
by
micro-CT
histology,
immunohistochemistry.
MLOY4
were
P.
gingivalis-derived
lipopolysaccharide
(LPS)+advanced
glycosylated
end
products
(AGEs)
mimicking
condition
vitro,
ferrostatin-1
(ferroptosis
inhibitor).
Osteocyte
expression
inflammatory
mediators
analyzed.
aggravated
inhibited
GPX4
SLC7A11
alleviated
these
effects.
LPS+AGEs
triggered
vitro
as
indicated
downregulated
SLC7A11,
upregulated
malondialdehyde,
disrupted
mitochondrial
morphology,
overexpressed
pro-inflammatory
IL-1β,
TNF-α,
SOST,
RANKL,
IL-6,
treatment
reversed
pIKBα
pNF-κB
p65
osteocytes,
this
effect.
In
conclusion,
triggers
possibly
via
disruption
SLC7A11/GPX4
axis,
has
correct
biological
event.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 6, 2023
Introduction:
Periodontitis
is
a
chronic
inflammatory
oral
disease
that
destroys
soft
and
hard
periodontal
support
tissues.
Multiple
cell
death
modes
including
apoptosis,
necroptosis,
pyroptosis,
ferroptosis
play
crucial
role
in
the
pathogenicity
of
diseases.
This
study
aimed
to
identify
genes
associated
with
ferroptosis,
pyroptosis
different
cells
present
periodontium
periodontitis
patients.
Methods:
Gingival
tissues'
mRNA
sequencing
dataset
GSE173078
12
healthy
control
patients'
microarray
GSE10334
63
controls
64
were
obtained
from
Gene
Expression
Omnibus
(GEO)
database.
A
total
910
differentially
expressed
(DEGs)
intersected
ferroptosis-related
obtain
differential
(DCDEGs),
expression
levels
21
verified
GSE10334.
Results:
Bioinformatic
analysis
revealed
attributed
necroptosis
patients
compared
controls.
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses
related
various
cellular
immunological
pathways
responses,
osteoclast
differentiation.
Additionally,
single-cell
RNA
(scRNA)
data
GSE171213
4
5
tissue
was
analyzed
clustering
types
death.
We
found
among
DCDEGs,
SLC2A3,
FPR2,
TREM1,
IL1B
mainly
upregulated
neutrophils
overlapping
IL-1B
TREM1
FPR2
are
SLC2A3
ferroptosis.
Finally,
we
utilized
CIBERSORT
algorithm
assess
association
between
DCDEGs
immune
infiltration
phenotypes,
based
on
gene
profile
The
results
positively
correlated
neutrophil
periodontium.
Discussion:
findings
provide
as
future
research
direction
mode
mechanism
their
pathogenicity.
Aging Medicine,
Год журнала:
2024,
Номер
7(1), С. 5 - 51
Опубликована: Фев. 1, 2024
Abstract
With
the
deepening
of
aging
in
China,
prevalence
diabetes
older
people
has
increased
noticeably,
and
standardized
management
is
critical
for
improving
clinical
outcomes
people.
In
2021,
National
Center
Gerontology,
Chinese
Society
Geriatrics,
Diabetes
Professional
Committee
Aging
Well
Association
organized
experts
to
write
first
guideline
diagnosis
treatment
Guideline
Management
Mellitus
Elderly
China
(2021
Edition)
.
The
emphasizes
that
patients
with
are
a
highly
heterogeneous
group
requiring
comprehensive
assessment
stratified
individualized
strategies.
proposes
simple
treatments
de‐intensified
strategies
diabetes.
This
edition
provides
clinicians
practical
operable
guidance,
thus
greatly
contributing
full‐cycle
promoting
extensive
development
basic
research
on
related
fields.
past
3
years,
evidence‐based
medicine
fields
further
advanced,
new
concepts,
drugs,
technologies
have
been
developed.
editorial
committee
promptly
updated
compiled
(2024
More
precise
paths
proposed,
achieving
continued
standardization
their
outcomes.
