Frontiers in Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Сен. 14, 2022
Long-term
alcohol
exposure
is
associated
with
oxidative
stress,
endoplasmic
reticulum
(ER)
and
neuroinflammation,
which
may
impair
cognitive
function.
Probiotics
supplements
can
significantly
improve
function
in
neurodegenerative
diseases
such
as
Alzheimer's
disease.
Nevertheless,
the
effect
of
Lactobacillus
plantarum
ST-III
culture
supernatant
(LP-cs)
on
alcohol-induced
dysfunction
remains
unclear.A
mouse
model
was
established
by
intraperitoneal
injection
(2
g/kg
body
weight)
for
28
days.
Mice
were
pre-treated
LP-cs,
evaluated
using
Morris
water
maze
test.
Hippocampal
tissues
collected
biochemical
molecular
analysis.LP-cs
ameliorated
decline
learning
memory
hippocampal
morphology
changes,
neuronal
apoptosis,
synaptic
dysfunction.
A
mechanistic
study
showed
that
activated
protein
kinase
R-like
(PERK)
signaling
suppressed
brain
derived
neurotrophic
factor
(BDNF)
levels
via
ER
stress
hippocampus,
LP-cs
reversed.
Alcohol
inflammation
responses
reversed.LP-cs
cellular
stress.
might
serve
an
effective
treatment
Biomedicines,
Год журнала:
2023,
Номер
11(7), С. 2056 - 2056
Опубликована: Июль 21, 2023
Bacterial
Extracellular
Vesicles
(BEVs)
possess
the
capability
of
intracellular
interactions
with
other
cells,
and,
hence,
can
be
utilized
as
an
efficient
cargo
for
worldwide
delivery
therapeutic
substances
such
monoclonal
antibodies,
proteins,
plasmids,
siRNA,
and
small
molecules
treatment
neurodegenerative
diseases
(NDs).
BEVs
additionally
a
remarkable
capacity
delivering
these
therapeutics
across
blood-brain
barrier
to
treat
Alzheimer's
disease
(AD).
This
review
summarizes
role
advancement
NDs,
AD,
their
treatment.
Additionally,
it
investigates
critical
BEV
networks
in
microbiome-gut-brain
axis,
defensive
offensive
roles
interaction
NDs.
Furthermore,
part
neuroimmune
system
interference
ND,
well
risk
factors
made
by
autophagy-lysosomal
pathway
potential
outcomes
on
are
all
discussed.
To
conclude,
this
aims
gain
better
understanding
credentials
NDs
possibly
discover
new
strategies.
ACS Omega,
Год журнала:
2024,
Номер
9(19), С. 21221 - 21233
Опубликована: Май 1, 2024
Globally,
the
rise
in
neurodegenerative
issues
tandem
with
shifts
lifestyle
and
aging
population
has
prompted
a
search
for
effective
interventions.
Nutraceutical
compounds
have
emerged
as
promising
agents
addressing
these
challenges.
This
60-day
study
on
an
aluminum-induced
cognitive
impairment
rat
model
assessed
three
their
combinations:
probiotics
(Prob,
Lactobacillus
plantarum
[5
×
1010
CFU/day],
acidophilus
CFU/day]),
docosahexaenoic
acid
(DHA,
23.8
mg/day),
vitamin
D3
(VD3,
150
IU/day).
Behavioral
outcomes
were
evaluated
by
using
Morris
water
maze
novel
object
recognition
tests.
Glial
activation
was
through
immunofluorescence
analysis
of
GFAP/Iba1,
oxidative
stress
markers
brain
tissue
determined
measuring
levels
Malondialdehyde
(MDA)
Superoxide
dismutase
(SOD).
The
results
demonstrated
progressive
improvement
learning
memory
capacity.
aluminum
group
exhibited
poorest
performance
behavioral
test,
enhanced
GFAP/Iba1
activation,
elevated
markers.
Conversely,
DHA
+
Prob
VD3
treatment
best
maze.
combination
superior
maze,
accompanied
reduced
DG/CA1
regions.
Furthermore,
supplementation
showed
lower
CA3
region
antioxidant
activity.
In
summary,
supplementing
various
nutraceutical
combinations,
including
DHA,
VD3,
Prob,
displayed
notable
benefits
against
impairment.
These
encompassed
enhancement,
diminished
MDA
concentration,
increased
SOD
activity,
glial
indicated
Deciphering
the
molecular
communications
along
gut-brain
axis
can
help
in
understanding
pathophysiology
of
neurodegenerative
diseases
and
exploiting
gut
microbiome
for
therapeutics.
However,
microbes
their
metabolites
have
a
multifaceted
role
mediating
both
brain
physiology
pathology.
There
is
lack
how
when
this
tipped
what
are
those
contributing
factors,
at
local
(gut)
distal
(neuronal)
levels,
that
drive
imbalance.
Here
we
reviewed
its
context
summarized
different
factors
such
as
gut-microbial
diversity,
metabolites,
native
immune
system
integrity
epithelial
blood-brain
barriers
interconnected
collectively
define
involvement
gut-microbiome
pathologies.
It
also
underlines
need
multidisciplinary
tools
animal
models
to
simultaneously
reflect
on
many
these
better
correlate
with
clinical
observations
data
obtained
from
human
biopsies
fecal
samples.
Harnessing
will
herald
paradigm
shift
medicine
aging,
emphasizing
significance
broader
spectrum
health
disease.
Ageing Research Reviews,
Год журнала:
2024,
Номер
unknown, С. 102637 - 102637
Опубликована: Дек. 1, 2024
Alzheimer's
disease
(AD)
is
a
progressive,
degenerative
disorder
of
the
central
nervous
system.
Despite
extensive
research
conducted
on
this
disorder,
its
precise
pathogenesis
remains
unclear.
In
recent
years,
microbiota-gut-brain
axis
has
attracted
considerable
attention
within
field
AD.
The
gut
microbiota
communicates
bidirectionally
with
system
through
gut-brain
axis,
and
alterations
in
structure
function
can
influence
progression
Consequently,
regulating
to
mitigate
AD
emerged
as
novel
therapeutic
approach.
Currently,
numerous
studies
concentrate
intrinsic
relationship
between
paper,
we
summarize
multifaceted
role
present
detailed
strategies
targeting
microbiota,
including
treatment
Traditional
Chinese
Medicine
(TCM),
which
garnered
increasing
years.
Finally,
discuss
potential
for
modulating
alleviate
AD,
current
challenges
area
research,
provide
an
outlook
future
directions
field.
Frontiers in Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Сен. 14, 2022
Long-term
alcohol
exposure
is
associated
with
oxidative
stress,
endoplasmic
reticulum
(ER)
and
neuroinflammation,
which
may
impair
cognitive
function.
Probiotics
supplements
can
significantly
improve
function
in
neurodegenerative
diseases
such
as
Alzheimer's
disease.
Nevertheless,
the
effect
of
Lactobacillus
plantarum
ST-III
culture
supernatant
(LP-cs)
on
alcohol-induced
dysfunction
remains
unclear.A
mouse
model
was
established
by
intraperitoneal
injection
(2
g/kg
body
weight)
for
28
days.
Mice
were
pre-treated
LP-cs,
evaluated
using
Morris
water
maze
test.
Hippocampal
tissues
collected
biochemical
molecular
analysis.LP-cs
ameliorated
decline
learning
memory
hippocampal
morphology
changes,
neuronal
apoptosis,
synaptic
dysfunction.
A
mechanistic
study
showed
that
activated
protein
kinase
R-like
(PERK)
signaling
suppressed
brain
derived
neurotrophic
factor
(BDNF)
levels
via
ER
stress
hippocampus,
LP-cs
reversed.
Alcohol
inflammation
responses
reversed.LP-cs
cellular
stress.
might
serve
an
effective
treatment
