Benha Journal of Applied Sciences,
Год журнала:
2024,
Номер
9(3), С. 149 - 153
Опубликована: Март 1, 2024
Background:
Gold
nanoparticles
(GNPs)
have
garnered
considerable
attention
in
various
biomedical
applications
due
to
their
unique
physicochemical
properties.
Understanding
the
dose-dependent
histological
effects
of
GNPs
on
liver
tissue
animal
models
is
crucial
for
evaluating
safety
profile
and
optimizing
therapeutic
applications.
This
study
aimed
evaluate
hepatotoxicity
bacterially
derived
GNP
rat
proceeding
into
a
further
study.
Material
Methods:
Male
Wistar
rats
were
divided
four
groups:
control,
25,
50,
100,
200
mg/kg
GNP,
given
15-day
acclimatization
period.
The
subjected
lipid
peroxidation,
oxidative
stress,
histology
tests.
Results:
levels
ALT,
AST,
albumin
significantly
differed
from
control
group
(P<0.001),
as
revealed
Fig.
1.
results
that
treated
with
50
mg/Kg
had
most
beneficial
effects,
while
GSH
higher
100
mg/GNPs
than
groups
20
mg/L
GNPs.
In
addition,
GNPs-treated
showed
an
increase
inflammation
liver,
presence
inflammatory
cells.
Conclusion:
These
findings
emphasize
importance
thorough
evaluations
coming
research.
Medical Journal of Viral Hepatitis /Medical Journal of Viral Hepatitis,
Год журнала:
2023,
Номер
7.3(3), С. 1 - 6
Опубликована: Дек. 1, 2023
Background:
Energy
drinks
(EDs)
have
become
a
mainstay
for
many
people
looking
quick
energy
boost
thanks
to
their
enormous
rise
in
popularity
recent
years.However,
several
studies
brought
attention
the
possible
negative
health
consequences
linked
intake
of
these
drinks.Objective:
This
study
aimed
look
into
impact
EDs
on
liver
biochemical,
histology,
and
glucose
levels
as
well.Materials
methods:
Three
groups
rats
were
placed:
control
group,
red
bull
power
horse
each
receiving
regular
diet
daily
drink.liver,
kidney,
glucose,
insulin
evaluated.Further,
histological
examination
was
evaluated.Results:
ALT
AST
blood
significantly
higher
drink
compared
group.There
no
significant
differences
between
groups.Serum
creatinine
also
with
difference
groups.Random
sugar
groups.Insulin
group
both
groups,
but
there
change
groups.Additionally,
damage
confirmed
by
biopsy
patients
who
had
ingested
EDs.Conclusion:
The
use
like
has
been
shown
serious
adverse
effects
liver.Consequently,
it
is
important
be
aware
potential
risks
associated
consuming
drinks.
Materials
methods
source
ingredientsRed
Bull
bought
cans
(250
ml)
at
an
on-site
grocery
Alex.
Red
following
ingredients
100
ml
serving:
taurine
(400
mg),
sucrose
________________________
Saudi Pharmaceutical Journal,
Год журнала:
2024,
Номер
32(6), С. 102072 - 102072
Опубликована: Апрель 19, 2024
Silymarin
(SLR)
is
a
poorly
water-soluble
bioactive
compound
with
wide
range
of
therapeutic
activities.
Nanosized
silymarin
vesicles
(F1–F6)
were
prepared
by
the
solvent
evaporation
rehydration
method.
The
evaluated
for
vesicle
size,
surface
charge,
entrapment
efficiency,
and
drug
release
studies.
optimized
SLR
lipid
(F3)
was
further
modified
addition
cationic
polymer
chitosan.
After
that,
(F3C1)
assessed
permeation
flux,
antimicrobial
activity,
cell
viability,
molecular
docking
showed
nanometric
size
(<250
nm),
low
polydispersibility
index
(<0.05),
negative
high
(85–95
%).
study
result
demonstrated
maximum
91.2
±
2.8
%.
adding
chitosan
to
surface,
there
significant
change
in
index,
charge
(positive),
encapsulation
efficiency.
found
be
prolonged,
flux
also
increased
comparison
free
SLR.
A
comparative
observed
standard
drug.
viability
assay
IC50
value
F3C1
against
line.
Benha Journal of Applied Sciences,
Год журнала:
2024,
Номер
0(0), С. 181 - 185
Опубликована: Март 16, 2024
Background:
Diabetes
Mellitus
(DM)
poses
a
significant
global
health
challenge,
with
rising
prevalence
and
associated
complications.
Despite
available
treatments,
the
search
for
safer
more
effective
options
continues.
This
study
investigates
potential
of
chitosan-doped
gold
nanoparticles
(AuNPs-chito)
as
novel
therapeutic
approach
DM.
Chitosan
shows
promise
flexible
biomolecule
management
several
pathophysiological
problems
linked
to
diabetes
mellitus
because
its
dual
roles
an
antidiabetic
agent
medication
carrier
Methods:
Streptozotocin-induced
diabetic
rats
were
treated
AuNPs-chito,
various
biochemical
histopathological
parameters
assessed.
Results:
Our
data
indicate
that
AuNPs-Chito
administration
led
improvements
in
blood
glucose
levels,
lipid
profiles,
oxidative
stress
markers,
liver
function
compared
untreated
rats.
Histopathological
examination
revealed
restoration
hepatic
architecture
AuNPs-chito-treated
Conclusion:
These
findings
suggest
AuNPs-chito
may
offer
promising
strategy
managing
DM
by
mitigating
improving
metabolic
parameters.
Benha Journal of Applied Sciences,
Год журнала:
2024,
Номер
9(3), С. 175 - 179
Опубликована: Март 1, 2024
Background:
Pancreatitis,
a
prevalent
inflammatory
condition
affecting
the
pancreas,
presents
with
symptoms
such
as
abdominal
pain,
nausea,
and
vomiting.
The
quest
for
innovative
therapeutic
strategies
to
address
this
has
led
growing
interest
in
silver
nanoparticles
(AgNPs)
doped
chitosan
due
their
antimicrobial
anti-inflammatory
properties.
Chitosan,
natural
polysaccharide
derived
from
crustacean
exoskeletons,
exhibits
biocompatibility
various
biological
activities,
including
effects.
This
study
investigates
efficacy
of
AgNPs-Chito
alleviating
pancreatitis
an
animal
model
induced
by
oral
administration
ethyl
alcohol.
Methods:
Adult
male
Swiss
albino
rats
were
divided
into
control,
(pancreatitis
but
not
treated),
treated
groups.
Parameters
liver
function
markers,
blood
glucose
levels,
pancreatic
enzymes,
oxidative
markers
evaluated.
Results
indicate
that
treatment
significantly
improved
reduced
decreased
levels
enzymes
compared
group.
Furthermore,
exhibited
antioxidant
properties
reducing
reactive
oxygen
species
enhancing
glutathione
S-transferase
activity.
Histopathological
examination
revealed
protective
effects
on
tissue
integrity.
Conclusion:
These
findings
suggest
potential
benefits
mitigating
alcohol-induced
through
its
multifaceted
antimicrobial,
anti-inflammatory,
actions.
Further
research
is
warranted
elucidate
mechanisms
underlying
these
explore
translational
novel
therapy
pancreatitis.
Benha Journal of Applied Sciences,
Год журнала:
2024,
Номер
9(3), С. 149 - 153
Опубликована: Март 1, 2024
Background:
Gold
nanoparticles
(GNPs)
have
garnered
considerable
attention
in
various
biomedical
applications
due
to
their
unique
physicochemical
properties.
Understanding
the
dose-dependent
histological
effects
of
GNPs
on
liver
tissue
animal
models
is
crucial
for
evaluating
safety
profile
and
optimizing
therapeutic
applications.
This
study
aimed
evaluate
hepatotoxicity
bacterially
derived
GNP
rat
proceeding
into
a
further
study.
Material
Methods:
Male
Wistar
rats
were
divided
four
groups:
control,
25,
50,
100,
200
mg/kg
GNP,
given
15-day
acclimatization
period.
The
subjected
lipid
peroxidation,
oxidative
stress,
histology
tests.
Results:
levels
ALT,
AST,
albumin
significantly
differed
from
control
group
(P<0.001),
as
revealed
Fig.
1.
results
that
treated
with
50
mg/Kg
had
most
beneficial
effects,
while
GSH
higher
100
mg/GNPs
than
groups
20
mg/L
GNPs.
In
addition,
GNPs-treated
showed
an
increase
inflammation
liver,
presence
inflammatory
cells.
Conclusion:
These
findings
emphasize
importance
thorough
evaluations
coming
research.
