Traditional use of Lablab purpureus (L.) Sweet as an abortifacient and antifertility among Karbi tribe of Assam, North East India

Plant Science Today, Год журнала: 2024, Номер unknown

Опубликована: Май 22, 2024

Lablab purpureus (L.) Sweet, a multipurpose leguminous plant is traditionally used as an antifertility and abortifacient agent among the Karbi, indigenous tribe living in Assam, North East India. The present study emphasized scientific validation of utilization this extract along with their physicochemical, phytochemical, silico ADME features. Fresh roots (450 gm) are processed for preliminary phytochemical screening, GC-MS analysis. Organoleptic studies, moisture content, swelling index, flow properties (Carr’s index Hausner ratio), extractive values (highest aqueous extract), ash content revealed plants potential sources phytomedicines having minimum required parameters per WHO standards. value Carr’s (22%) Hausner's ratio (1.27) indicates that powder drugs have greater inter-particle interactions, which signifies poor flowing powder. Phytochemical screening root extracts showed presence flavonoids, tannins, phenolic compounds, alkaloids, coumarins, terpenoids. analysis Arsenous acid tris(trimethylsilyl; Cyclic siloxane compounds; Pivalic Acid, 2-Methylpropyl Ester; Propanoic 2,2-Dimethyl-, Ethyl Ester N-(Trifluoroacetyl)-N, O, O', O''-Tetrakis (Trimethylsilyl) Norepinephrine, reproductive developmental toxicity also stimulates progesterone production. According to SwissADME, drug-like Tri Ester, Heptasiloxane, etc., identified use orally active medicine. Since L. has been by Karbi ages contains bioactive compounds such abortifacient, it may be considered important ethnomedicine. Laboratory animal experimentation studied more future its precise effectiveness advance drug-discovery process.

Язык: Английский

Isolation of two new cucurbitane-type triterpenoids from Kedrostis gijef

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Июнь 17, 2024

Two new cucurbitane-type triterpenoids (2,3), together with two known compounds (1,4), were isolated from the aerial parts of Kedrostis gijef. The structure all was elucidated based on NMR, HRESIMS analyses, and by comparison literature. Additionally, cytotoxic activity against HeLa, Caco-2, SH-SY5Y cell lines determined using MTT colorimetric assay.

Язык: Английский