A Crosstalk between Mosquito Borne Dengue Virus in the Lung Microenvironment DOI Creative Commons
Amrita Vats

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

There are reports of several respiratory viruses identified in the lung. However, existence dengue virus (DENV) particle is still its infancy. We have thoroughly discussed components and traits lung cells’ involvement DENV infection detail. In this chapter, our goal to focus on unraveling key elements epithelial microenvironment, microbiota niche their participation spread patient outcome. also talked about crucial aspect lung-gut axis, host mosquito variables that may influence how a progresses, potential connection between sepsis damage after infection. natively concentrate aimed emphasize incidence manifestations dengue-infected individuals, correlation with outcomes DENV’s microenvironment. This report will introduce new field inquiry finding critical underlying unknown cause solving puzzle diagnosis.

Язык: Английский

Zika virus exists in enterocytes and enteroendocrine cells of the Aedes aegypti midgut DOI Creative Commons
Tse-Yu Chen, Hamidah Raduwan, Alejandro Marín-López

и другие.

iScience, Год журнала: 2024, Номер 27(7), С. 110353 - 110353

Опубликована: Июнь 22, 2024

The

Язык: Английский

Процитировано

5
Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity DOI Creative Commons
Víctor Cardoso-Jaime, George Dimopoulos

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 8, 2025

For successful transmission, the malaria parasite must traverse tissue epithelia and survive attack from insect's innate immune system. Hemocytes play a multitude of roles in mosquitoes, including defense against invading pathogens. Here, we show that hemocytes major vector Anopheles gambiae promote Plasmodium falciparum infection by maintaining midgut epithelial integrity controlling cell proliferation upon blood feeding. The mosquito's also control microbiota gene expression. Our study unveils novel hemocyte functions are exploited human to evade Cardoso Dimopoulos mosquito macrophages-like cells agonists early stages critical role

Язык: Английский

Процитировано

0
Juvenile Hormone as a contributing factor in establishing midgut microbiota for fecundity and fitness enhancement in adult female Aedes aegypti DOI Creative Commons
Mabel L. Taracena, Ana Beatriz Walter‐Nuno, Vanessa Bottino-Rojas

и другие.

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Июнь 5, 2024

Abstract Understanding the factors influencing mosquitoes’ fecundity and longevity is important for designing better more sustainable vector control strategies, as these parameters can impact their vectorial capacity. Here, we address how mating affects midgut growth in Aedes aegypti , what role Juvenile Hormone (JH) plays this process, it impacts mosquito’s immune response microbiota. Our findings reveal that JH induce growth. Additionally, establishment of a native bacterial population due to JH-dependent suppression has reproductive outcomes. Specific downregulation AMPs with an increase bacteria abundance gut results increased egg counts longer lifespans. Overall, provide evidence cross-talk between response, epithelial tissue, cell cycle regulation, mechanisms governing trade-offs nutrition, immunity, reproduction at cellular level mosquito gut.

Язык: Английский

Процитировано

4
Influence of blood-feeding and infection on arthropod hemocytes DOI Creative Commons
George-Rafael Samantsidis, Shahid Karim, Ryan C. Smith

и другие.

Current Opinion in Insect Science, Год журнала: 2025, Номер unknown, С. 101341 - 101341

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Mosquito symbionts, immunity, and vector competence for arboviruses DOI
Louis Lambrechts

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Reciprocal interactions between neuropeptide F and RYamide regulate host attraction in the mosquito Aedes aegypti DOI Creative Commons
Xiaoyi Dou, Kangkang Chen, Mark R. Brown

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(28)

Опубликована: Июль 1, 2024

Female mosquitoes produce eggs in gonadotrophic cycles that are divided between a previtellogenic and vitellogenic phase. Previtellogenic females consume water sugar sources like nectar while also being attracted to hosts for blood feeding. Consumption of meal activates the phase, which produces mature suppresses host attraction. In this study, we tested hypothesis neuropeptide Y-like hormones differentially modulate attraction behavior mosquito Aedes aegypti . A series experiments collectively indicated enteroendocrine cells (EECs) posterior midgut release F (NPF) into hemolymph during phase stimulates humans biting behavior. meal, primarily consists protein by dry weight, down-regulated NPF EECs until developed, was associated with decline titer. depletion depended on digestion but not EEC loss. Other showed neurons terminal ganglion extend axons RYamide, evidence increased secretion circulation after meal. Injection RYamide-1 -2 suppressed attraction, coinjection RYamides or without short NPF-2 inhibited activity NPF. Overall, our results identify RYamide as gut-associated A. link shifts diet sequential cycles.

Язык: Английский

Процитировано

1
Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal DOI Creative Commons
Thomas Vial, Hélène Lopez-Maestre, Élodie Couderc

и другие.

Опубликована: Ноя. 11, 2024

SUMMARY Aedes aegypti mosquitoes are vectors for numerous arboviruses that have an increasingly substantial global health burden. Following a bloodmeal, experience significant physiological changes, primarily orchestrated by the midgut and fat body tissues. These changes begin with digestion culminate in egg production. However, our understanding of those key processes at cellular molecular level remains limited. We created comprehensive cell atlas mosquito employing single-cell RNA sequencing metabolomics techniques. This unveils dynamic composition metabolic adaptations occur following bloodmeal. Our analyses reveal highly diverse populations, specialized digestion, metabolism, immunity, reproduction. While comprises enterocytes, enteroendocrine intestinal stem cells, consists not only trophocytes oenocytes, but also harbors hemocyte population newly found body-yolk population. The exhibits complex metabolomic profile exerts central role coordinating immune processes. Additionally, insect-specific virus, PCLV (Phasi Charoen-Like Virus) was detected single mainly week after findings highlight complexity mosquito’s abdominal tissues, pave way towards development exquisitely refined vector control strategies consisting genetically targeting specific populations pathways necessary

Язык: Английский

Процитировано

1
A Crosstalk between Mosquito Borne Dengue Virus in the Lung Microenvironment DOI Creative Commons
Amrita Vats

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

There are reports of several respiratory viruses identified in the lung. However, existence dengue virus (DENV) particle is still its infancy. We have thoroughly discussed components and traits lung cells’ involvement DENV infection detail. In this chapter, our goal to focus on unraveling key elements epithelial microenvironment, microbiota niche their participation spread patient outcome. also talked about crucial aspect lung-gut axis, host mosquito variables that may influence how a progresses, potential connection between sepsis damage after infection. natively concentrate aimed emphasize incidence manifestations dengue-infected individuals, correlation with outcomes DENV’s microenvironment. This report will introduce new field inquiry finding critical underlying unknown cause solving puzzle diagnosis.

Язык: Английский

Процитировано

0