Current Opinion in Food Science, Год журнала: 2024, Номер 58, С. 101184 - 101184
Опубликована: Июнь 17, 2024
Язык: Английский
Nature Reviews Microbiology, Год журнала: 2024, Номер 22(11), С. 671 - 686
Опубликована: Июль 15, 2024
Язык: Английский
Процитировано
145
JAMA Network Open, Год журнала: 2023, Номер 6(3), С. e234714 - e234714
Опубликована: Март 28, 2023
Importance Plant-based diets have gained popularity for both environmental and health reasons, but a comprehensive assessment of their quality in relation to risk mortality major chronic diseases is lacking. Objective To examine whether healthful vs unhealthful plant-based dietary patterns are associated with among UK adults. Design, Setting, Participants This prospective cohort study used data from adults the Biobank, large-scale population-based study. were recruited between 2006 2010 followed up using record linkage until 2021; follow-up different outcomes ranged 10.6 12.2 years. Data analysis was conducted November 2021 October 2022. Exposures Adherence diet index (hPDI uPDI) derived 24-hour assessments. Main Outcomes Measures The main hazard ratios (HRs) 95% CIs (overall cause specific), cardiovascular disease (CVD [total, myocardial infarction, ischemic stroke, hemorrhagic stroke]), cancer (total, breast, prostate, colorectal), fracture vertebrae, hip) across quartiles hPDI uPDI adherence. Results included 126 394 Biobank participants. They had mean (SD) age 56.1 (7.8) years; 70 618 (55.9%) women. majority participants (115 371 [91.3%]) White. Greater adherence lower risks total mortality, cancer, CVD, HRs (95% CIs) 0.84 (0.78-0.91), 0.93 (0.88-0.99), 0.92 (0.86-0.99), respectively, highest quartile compared lowest. also infarction 0.86 (0.78-0.95) (0.71-0.99), respectively. By contrast, higher scores cancer. associations observed did not show heterogeneity strata sex, smoking status, body mass index, or socioeconomic status polygenic (specifically regard CVD end points). Conclusions Relevance findings this middle-aged suggest that characterized by high-quality foods intakes animal products may be beneficial health, irrespective established factors genetic predisposition.
Язык: Английский
Процитировано
105
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113810 - 113810
Опубликована: Окт. 8, 2022
The human gut microbiota is a complex ecosystem involved in the metabolism, immunity, and health of host. microbiome plays key role development host's innate adaptive immune system, while system orchestrates maintenance host-microbe symbiosis. Lung diseases are usually accompanied by dysbiosis intestinal flora an immune-inflammatory response. its metabolites directly or indirectly regulation host lung disease. However, exact mechanism action gut-lung axis crosstalk remains unclear. This review aimed to summarize latest advances their typical diseases, such as pulmonary hypertension, COPD, cancer. Especially COVID-19, problem troubling world, also discussed it. Moreover, it concentrated on mechanisms between identified specific link among microbiota, metabolites, regulation, which could be used breakthrough find new targets for some without therapeutic drugs clinic. It tool "drug-bacterial interaction" potential applications would provide clear direction future research propose strategy targeting
Язык: Английский
Процитировано
87
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
30
The Lancet Regional Health - Europe, Год журнала: 2024, Номер 43, С. 100948 - 100948
Опубликована: Июнь 13, 2024
Язык: Английский
Процитировано
26
iMeta, Год журнала: 2025, Номер 4(1)
Опубликована: Фев. 1, 2025
Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.
Язык: Английский
Процитировано
3
MedComm, Год журнала: 2023, Номер 4(1)
Опубликована: Фев. 1, 2023
Abstract For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed rapid development of field dietary patterns cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy with emphasis on food‐based recommendations are gold standard extending lifespan reducing risks CMD mortality. Healthy include various permutations energy restriction, macronutrients, food intake such as calorie intermittent fasting, Mediterranean diet, plant‐based diets, etc. Early implementation in patients is encouraged, but an understanding mechanisms by which these trigger benefits remains incomplete. Hence, this review examined several may improve health, including restrictive patterns, regional diets based controlled macronutrients groups, summarizing cutting‐edge evidence potential treatment. Particularly, considering individual differences responses composition changes organ tissue diversity, we highlighted critical role gut microbiota crosstalk between diet recommend a more precise dynamic strategy developing profiles.
Язык: Английский
Процитировано
30
European Journal of Nutrition, Год журнала: 2025, Номер 64(2)
Опубликована: Фев. 1, 2025
Plant-based diets are increasingly recognized for cancer prevention, yet their specific impact on lung (LC) risk remains insufficiently examined. This study aims to assess the relationship between plant-based adherence and incidence of LC. Data from Prostate, Lung, Colorectal, Ovarian screening trial were analyzed. The diet index (PDI) was developed diets. Multivariable Cox regression model performed estimate hazard ratios (HRs) 95% confidence intervals (CIs). Restricted cubic spline (RCS) examine across PDI spectrum. Prespecified subgroup analyses identified potential modifiers, sensitivity tested association's robustness. Of 98,459 participants included, 1,642 LC over an average follow-up 8.83 years. Higher scores associated with a lower (HR quartile 4 vs. 1: 0.75, CI: 0.65–0.87, P trend < 0.001), evident in both non-small cell 0.76, 0.65–0.88, 0.001) small 0.73, 0.49–1.09, = 0.046). RCS further confirmed these relationships. association stronger among BMI, smokers, those without history emphysema or diabetes, family LC, physical activity (all 0.001). Sensitivity consistently supported findings. Our findings reveal inverse correlation risk, supporting benefits prevention. ClinicalTrials.gov ID: NCT00339495 (URL: https://www.clinicaltrials.gov/study/NCT00339495 ).
Язык: Английский
Процитировано
2
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217539 - 217539
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Nutrients, Год журнала: 2025, Номер 17(5), С. 884 - 884
Опубликована: Фев. 28, 2025
The global shift towards vegan and vegetarian diets has garnered attention for their ethical, environmental, potential health benefits. These are often rich in phytonutrients antioxidants, which have been associated with lower levels of inflammatory markers, such as C-reactive protein (CRP) interleukin-6 (IL-6), suggesting a protective effect against systemic inflammation oxidative stress. However, despite these benefits, concerns remain regarding impact on neurological due to the possible deficiencies critical nutrients vitamin B12, DHA, EPA, iron. This review critically evaluates influence dietary patterns outcomes, emphasizing nutritional composition, deficiencies, interplay A systematic literature published between 2010 2023 was conducted, focusing studies that explore relationship health. Key omega-3 fatty acids, iron, zinc were analyzed alongside antinutritional factors effects nervous system. Evidence suggests diets, when well planned, can be (IL-6). findings indicate role reducing stress, both linked neurodegenerative diseases. iron consistently an increased risk cognitive decline, mood disturbances, disorders. Additionally, presence like phytates oxalates may further impair nutrient absorption, necessitating careful planning supplementation. While plant-based provide anti-inflammatory antioxidant implications depend adequacy. Proper planning, supplementation, food preparation techniques essential mitigate risks enhance Further research is needed long-term outcomes optimize strategies.
Язык: Английский
Процитировано
2