Partial reduction of interleukin‐33 signaling improves senescence and renal injury in diabetic nephropathy DOI Creative Commons
Li Chen, Chao Gao,

Xingzhu Yin

и другие.

MedComm, Год журнала: 2024, Номер 5(11)

Опубликована: Окт. 24, 2024

Abstract Diabetic nephropathy (DN) is a frequent and costly complication of diabetes with limited understandings mechanisms therapies. Emerging evidence points to the important roles interleukin‐33 (IL‐33) in acute kidney injury, yet its contribution DN still unclear. We here found ubiquitous increase IL‐33 receptor (ST2) murine models patients DN. Surprisingly, both ST2 knockdown aggravated renal lesions DN, while overexpression also exacerbated condition. Further population‐based analyses revealed positive correlation expression dysfunction patients. Individuals high expression‐related polygenic risk score had higher risk. These findings confirmed harmful effects on Conversely, endogenous exogenous partial reduction signaling conferred renoprotective vivo vitro. Mechanistically, induced senescence by regulating cell cycle factors HK‐2 cells, accordingly led damage through secretion senescence‐related secretory phenotype (SASP) including prostaglandins. Together, elevated accelerates cellular drive possibly SASP production, blockage improves injury senescence. Our pinpoint possible new avenue for interventions.

Язык: Английский

Long-term changes in frailty and incident atrial fibrillation, heart failure, coronary heart disease, and stroke: A prospective follow-up study DOI

Lingli Cai,

Ying Sun, Jingjing Zhu

и другие.

Heart Rhythm, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Social Isolation, Loneliness, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes Mellitus DOI Creative Commons
Yannis Yan Liang, Yu He, Jinyu Wang

и другие.

American Journal of Kidney Diseases, Год журнала: 2024, Номер 84(5), С. 557 - 566.e1

Опубликована: Июнь 24, 2024

Rationale & ObjectiveSocial disconnection has been associated with poor cardiometabolic health. This study sought to investigate the associations of social isolation and loneliness diabetic microvascular complications (DMC) among individuals type 2 diabetes mellitus (T2DM) compare these those related traditional risk factors.Study DesignProspective cohort study.Setting ParticipantsA total 24,297 UK Biobank participants T2DM no DMC at baseline.ExposureSocial measured using self-reported questionnaires.OutcomeThe incidence defined as a composite kidney disease, retinopathy, or neuropathy.Analytical ApproachMultivariable cause-specific hazards regression. To relative importance other established factors, R2 values Cox models were calculated.ResultsDuring median follow-up 12.6 years, 5,530 patients documented develop (3,458 2,255 1,146 neuropathy). The highest level was an increased any component (most vs. least: HR: 1.13; 95% CI: 1.05-1.22), especially disease (HR: 1.14, 1.04-1.25) neuropathy 1.31, 1.11-1.53). Any 1.12; 1.02-1.23) 1.16, 1.03-1.30). Social exhibited comparable conventional factors including smoking, blood pressure, physical activity.LimitationsLimited generalizability composition in Study.ConclusionsSocial independently higher incident T2DM, factors. These findings underscore novel potentially modifiable for DMC.

Язык: Английский

Процитировано

7
Frailty, genetic predisposition, and incident atrial fibrillation DOI Creative Commons
Ying Sun,

Yinuo Zhou,

Bowei Yu

и другие.

European Heart Journal, Год журнала: 2024, Номер 45(14), С. 1281 - 1283

Опубликована: Март 5, 2024

Journal Article Frailty, genetic predisposition, and incident atrial fibrillation Get access Ying Sun, Sun Institute Department of Endocrinology Metabolism, Shanghai Ninth People's Hospital, JiaoTong University School Medicine, No. 639 Zhizaoju Road, Huangpu District, 200011, China https://orcid.org/0000-0002-8529-3521 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yinuo Zhou, Zhou Bowei Yu, Yu Kun Zhang, Zhang Bin Wang, Wang Xiao Tan, Tan Big Data in Health Science, Zhejiang University, Hangzhou, ChinaDepartment Medical Sciences, Uppsala Uppsala, Sweden Yingli Lu, Lu Corresponding author. Tel: +86 21 23271699, Email: [email protected] (N.W.), [email protected] (Y.L.) https://orcid.org/0000-0002-5117-1614 Ningjian https://orcid.org/0000-0001-9591-6991 European Heart Journal, ehae130, https://doi.org/10.1093/eurheartj/ehae130 Published: 05 March 2024 history Received: 12 December 2023 Revision received: 13 January Accepted: 15 February

Язык: Английский

Процитировано

6
Genetically Predicted Frailty Index Is Associated With Increased Risk of Multiple Metabolic Diseases: 175 226 European Participants in a Mendelian Randomization Study DOI Creative Commons
Hexing Wang, Haifeng Zhang, Dongliang Tang

и другие.

Journal of Diabetes, Год журнала: 2025, Номер 17(3)

Опубликована: Март 1, 2025

A relationship between frailty index (FI) and metabolic diseases (MDs) has been reported in previous observational studies. However, the causality them remains unclear. This study aimed to examine causal effect of FI on MDs. We performed a bidirectional two-sample Mendelian randomization (MR) study. recent large-scale genome-wide association (GWAS) provided available data associated with FI, summary statistics eight MDs were collected from IEU OpenGWAS database. Inverse variance weighted (IVW) was used as main analysis estimate effects, together MR pleiotropy residual sum outlier (MR-PRESSO), MR-Egger, Cochran's Q test, leave-one-out method, Steiger sensitivity analyses. Our demonstrated for first time that elevated causally an increased risk including obesity (odds ratio [OR] = 1.78; 95% confidence interval [CI]: 1.17-2.70; p 0.0075), T2DM (OR 1.67; CI: 1.24-2.24; 6.95 × 10-4), gout 2.45; 1.29-4.64; 0.006), hypothyroidism 1.96; 1.47-2.60; 3.47 10-6), HTN 2.17; 1.72-2.74; 5.25 10-11). no found osteoporosis, vitamin D deficiency, hyperthyroidism. findings support multiple is crucial prevention patients frailty.

Язык: Английский

Процитировано

0
Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS) DOI Creative Commons
Lisha Zhang,

Chao Chu,

Yan Zhang

и другие.

Acta Diabetologica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0
Joint Physical-Psychosocial Frailty and Risks of All-Cause and Cause-Specific Premature Mortality DOI Creative Commons
Jian Zhou, Minghao Kou, Rui Tang

и другие.

Journal of General Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Abstract Background The importance of integrating physical and psychosocial factors in assessing frailty -health outcomes has been increasingly acknowledged, while the related evidence is lacking. We sought to investigate associations joint physical-psychosocial with risk premature mortality evaluate relative individual factors. Design A total 381,295 participants no history cancer or cardiovascular disease (CVD) were recruited from UK Biobank cohort. was evaluated based on seven indicators including weight loss, exhaustion, activity, walking pace, grip strength, social isolation, loneliness. all causes, cancer, CVD, other causes. Cox proportional hazards models used assess between mortality. Key Results During a median follow-up period 12.7 years, we recorded 20,328 deaths. Each additional increment index associated 26% (HR 1.26, 95% CI 1.24–1.28), 10% 1.10, 1.08–1.12), 30% 1.30, 1.26–1.33), 44% 1.44, 1.41–1.47) higher all-cause, cardiovascular, other-cause mortality, respectively. Compared 0, those ≥ 4 had 2.67 (95% 2.49–2.87)-fold all-cause Slow pace isolation top two strongest predictors for In addition, found that lower body mass (BMI), age, smoking status, dietary quality modified ( P -interaction < 0.05). Conclusions this cohort study participants, significantly risks cause-specific highlighting jointly determining aging-related health.

Язык: Английский

Процитировано

0
Sleep duration, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A prospective cohort study DOI Creative Commons

Xuegang Niu,

Hongwei Liu,

Yanxi Wang

и другие.

Diabetes Research and Clinical Practice, Год журнала: 2025, Номер unknown, С. 112026 - 112026

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Related factors of cognitive frailty among older adults with type 2 diabetes: a cross‐sectional study DOI Open Access
M. Y. Cheng, Yan Qiao, Bailin Yang

и другие.

Psychogeriatrics, Год журнала: 2025, Номер 25(2)

Опубликована: Фев. 11, 2025

Abstract Background The correlation between diabetes and cognitive frailty is still controversial. purpose of this study was to explore the related factors in older adults with type 2 diabetes, provide new ideas for realising healthy ageing diabetic patients. Methods survey conducted at Mianyang Central Hospital affiliated University Electronic Science Technology China from January 15 June 30, 2024. subjects were aged 60 years or older. Cognitive assessed using Fried's phenotype Mini‐Mental State Examination. Statistical analysis plotting SPSS 25.0 R 4.3.3. Least absolute shrinkage selection operator (LASSO) regression used reduce dimensionality 30 clinical features collected, unimportant initially screened out. important non‐zero coefficients identified by LASSO included a multivariate logistic influencing Results This 301 persons diabetes. Among them, 91 (30.2%) cases occurred. Related include: age (odds ratio (OR) = 6.417, 95% CI: 1.882−21.876, P 0.003), hypomnesia (OR 2,985, 95%CI: 1.143−7.797, 0.026), depression 9.926, 4.117−23.934, < 0.001), retinopathy 6.489, 1.969−21.384, 0.002), history ketoacidosis 12.024, 1.724−83.872, 0.012). Conclusion prevalence mellitus higher. It closely age, hypomnesia, depression, ketoacidosis. Early detection risk effective intervention can incidence adverse events improve quality life

Язык: Английский

Процитировано

0
Yaşlı diyabetli hastalarda mikrovasküler komplikasyonları tahmin etmede idrar biyobelirteçlerinin ve kendi kendine kan glikozu izlemenin tanısal performansı DOI Open Access
Muzaffer Serdar Deniz, Fatih Karataş

Turkish Journal of Clinics and Laboratory, Год журнала: 2025, Номер 16(1), С. 228 - 235

Опубликована: Март 25, 2025

Amaç: Yaşlı hastalarda yaşam kalitesini artırmak ve ciddi patolojileri önlemek için diabetes mellitus (DM) ile ilişkili komplikasyonların saptanması çok önemlidir. Bu çalışmanın amacı, DM'li yaşlı erişkinlerde üriner mikroalbümin-kreatinin oranı (uMCR), protein-kreatinin (uPCR) kendi kendine kan şekeri takibinin (SMBG) nöropati, retinopati nefropatiyi gibi mikrovasküler komplikasyonları tahmin etmedeki tanısal performansını değerlendirmektir. Yöntem: metodolojik çalışmada, endokrinoloji kliniğinde takip edilen 64 yaş üstü DM hastalarının (n=99) serum hemoglobin A1c (HbA1c), trigliserid-glukoz indeksi (TyG indeksi), SMBG ölçülen en yüksek düşük düzeyleri farkı (SMBGfarkı) SMBGfarkı düzeyinin (SMBGoranı), uMCR uPCR değerleri, güçleri ROC analiziyle değerlendirildi. Tanısal performansa sahip olanların kesim değerleri sensitivite spesifiteleri hesaplanmıştır. Bulgular: %70'inin erkek olduğunu, %48,5'inde %25,3'ünde nefropati olduğunu göstermiştir. Lipid metabolizması karaciğerle ilgili göstergeler normal aralıkta olmasına rağmen, D vitamini eksikliği görülmüştür. analizi, düzeylerinin bağımsız olarak (p

Процитировано

0
Frailty and risk of microvascular disease in adults with prediabetes DOI
Pingting Zhong,

Riqian Liu,

Zhuoting Zhu

и другие.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(1), С. 102942 - 102942

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

3