Abstract
Diabetic
nephropathy
(DN)
is
a
frequent
and
costly
complication
of
diabetes
with
limited
understandings
mechanisms
therapies.
Emerging
evidence
points
to
the
important
roles
interleukin‐33
(IL‐33)
in
acute
kidney
injury,
yet
its
contribution
DN
still
unclear.
We
here
found
ubiquitous
increase
IL‐33
receptor
(ST2)
murine
models
patients
DN.
Surprisingly,
both
ST2
knockdown
aggravated
renal
lesions
DN,
while
overexpression
also
exacerbated
condition.
Further
population‐based
analyses
revealed
positive
correlation
expression
dysfunction
patients.
Individuals
high
expression‐related
polygenic
risk
score
had
higher
risk.
These
findings
confirmed
harmful
effects
on
Conversely,
endogenous
exogenous
partial
reduction
signaling
conferred
renoprotective
vivo
vitro.
Mechanistically,
induced
senescence
by
regulating
cell
cycle
factors
HK‐2
cells,
accordingly
led
damage
through
secretion
senescence‐related
secretory
phenotype
(SASP)
including
prostaglandins.
Together,
elevated
accelerates
cellular
drive
possibly
SASP
production,
blockage
improves
injury
senescence.
Our
pinpoint
possible
new
avenue
for
interventions.
Journal of Diabetes Investigation,
Год журнала:
2024,
Номер
15(11), С. 1675 - 1683
Опубликована: Авг. 14, 2024
The
clinical
significance
of
age-related
biomarkers
in
patients
with
diabetes
has
not
been
fully
elucidated.
In
this
study,
we
aimed
to
establish
models
predict
the
progression
aging
using
biomarkers.
Clinical Interventions in Aging,
Год журнала:
2024,
Номер
Volume 19, С. 1597 - 1606
Опубликована: Сен. 1, 2024
Current
scoring
systems
for
short-term
prognosis
in
patients
with
acute
myocardial
infarction
(AMI)
lack
coverage
of
risk
factors
and
have
limitations
stratification.
The
aim
this
study
was
to
develop
a
novel
assessment
system
based
on
laboratory
indicators
frailty
quantification
better
infer
indication
AMI.
Journal of the American Nutrition Association,
Год журнала:
2024,
Номер
44(3), С. 181 - 189
Опубликована: Окт. 15, 2024
Background
Current
guidelines
prioritize
monitoring
and
managing
cobalamin
(Cbl)
deficiency
but
insufficiently
address
the
issue
of
functional
Cbl
(decreased
sensitivity).
This
study
aims
to
investigate
prevalence
burden
examine
its
prospective
association
with
mortality
risk,
compared
deficiency,
among
United
States
(US)
adults.
Multiple Sclerosis Journal,
Год журнала:
2024,
Номер
30(13), С. 1653 - 1663
Опубликована: Окт. 17, 2024
Background:
People
with
multiple
sclerosis
(PwMS)
have
an
increased
cardiovascular
and
cerebrovascular
disease
burden,
but
this
could
be
mitigated
by
vascular
risk
factor
management.
Objectives:
We
compared
the
trajectories
of
factors,
comorbidities
clinical
management
in
PwMS
against
general
population
post-MS
diagnosis
while
controlling
for
frailty.
Methods:
Retrospective
longitudinal
analysis
using
English
data
from
Clinical
Practice
Research
Datalink
between
1987
2018
comprising
matched
up
to
six
controls
without
MS
age,
sex
practice.
Results:
12,251
72,572
controls;
3.8%
had
mild–moderate
frailty,
1.2%
more
than
controls.
Compared
controls,
elevated
incidence
Type
2
diabetes
(HR
1.18,
95%
CI
(1.04,
1.34)),
starting
antihypertensive
medications
1.40,
(1.33,
1.47)).
Among
those
hypertension
at
baseline,
blood
pressure
did
not
differ
rates
meeting
targets
1.25,
(1.12,
1.41)).
Conclusion:
The
observation
that
are
likely
meet
treatment
is
encouraging,
suggest
tighter
may
needed
population.
Abstract
Diabetic
nephropathy
(DN)
is
a
frequent
and
costly
complication
of
diabetes
with
limited
understandings
mechanisms
therapies.
Emerging
evidence
points
to
the
important
roles
interleukin‐33
(IL‐33)
in
acute
kidney
injury,
yet
its
contribution
DN
still
unclear.
We
here
found
ubiquitous
increase
IL‐33
receptor
(ST2)
murine
models
patients
DN.
Surprisingly,
both
ST2
knockdown
aggravated
renal
lesions
DN,
while
overexpression
also
exacerbated
condition.
Further
population‐based
analyses
revealed
positive
correlation
expression
dysfunction
patients.
Individuals
high
expression‐related
polygenic
risk
score
had
higher
risk.
These
findings
confirmed
harmful
effects
on
Conversely,
endogenous
exogenous
partial
reduction
signaling
conferred
renoprotective
vivo
vitro.
Mechanistically,
induced
senescence
by
regulating
cell
cycle
factors
HK‐2
cells,
accordingly
led
damage
through
secretion
senescence‐related
secretory
phenotype
(SASP)
including
prostaglandins.
Together,
elevated
accelerates
cellular
drive
possibly
SASP
production,
blockage
improves
injury
senescence.
Our
pinpoint
possible
new
avenue
for
interventions.
