Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis DOI Creative Commons
Lu Xiao, Shudian Lin, Feng Zhan

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 18, 2024

Abstract Evidence shows that primary gout is prone to develop atherosclerosis, but the mechanism of its occurrence still not fully clarified. The aim this study was explore molecular complication in gout. gene expression profiles and atherosclerosis were downloaded from omnibus database. Overlapping differentially expressed genes (DEGs) between identified. biological roles common DEGs explored through enrichment analyses. Hub identified using protein–protein interaction networks. immune infiltrations 28 types cells control samples GSE160170 evaluated by ssGSEA method. Transcription factors (TFs) predicted Transcriptional Regulatory Relationships Unraveled Sentence Based Text Mining (TRRUST) A total 168 overlapping Functional analyses indicated mostly enriched chemokine signaling pathway, regulation actin cytoskeleton, TNF pathway. CytoScape demonstrated 11 hub two cluster modules. infiltration analysis showed significantly upregulated activated CD4 T cells, gamma delta follicular helper cell, CD56dim natural killer eosinophil. TRRUST one TF, RUNX family transcription factor 1. Our pathogenesis with discovered These results may guide future experimental research clinical transformation.

Язык: Английский

Surface-based analysis of early cortical gyrification and thickness alterations in treatment-Naïve, first-episode depressive patients during emerging adulthood DOI

Azi Shen,

K. Shi,

Qiudong Xia

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Causal effects of nonalcoholic fatty liver disease on cerebral cortical structure: a Mendelian randomization analysis DOI Creative Commons
Zhiliang Mai, Hua Mao

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 1, 2023

Background Previous studies have highlighted changes in the cerebral cortical structure and cognitive function among nonalcoholic fatty liver disease (NAFLD) patients. However, impact of NAFLD on specific affected brain regions remains unclear. Therefore, we aimed to explore potential causal relationship between structure. Methods We conducted a Mendelian randomization (MR) study using genetic predictors alanine aminotransferase (ALT), NAFLD, percent fat (PLF) combined them with genome-wide association (GWAS) summary statistics from ENIGMA Consortium. Several methods were used assess effect full cortex regions, along sensitivity analyses. Results At global level, PLF nominally decreased SA cortex; at functional ALT presented nominal reduced parahippocampal gyrus, TH pars opercularis, orbitalis, pericalcarine cortex. Besides, triangularis cortex, but increased entorhinal lateral orbitofrontal temporal pole. Furthermore, cuneus lingual Conclusion is suggestively associated atrophy human brain.

Язык: Английский

Процитировано

3
Identification of hub genes and transcription factors in patients with primary gout complicated with atherosclerosis DOI Creative Commons
Lu Xiao, Shudian Lin, Feng Zhan

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 18, 2024

Abstract Evidence shows that primary gout is prone to develop atherosclerosis, but the mechanism of its occurrence still not fully clarified. The aim this study was explore molecular complication in gout. gene expression profiles and atherosclerosis were downloaded from omnibus database. Overlapping differentially expressed genes (DEGs) between identified. biological roles common DEGs explored through enrichment analyses. Hub identified using protein–protein interaction networks. immune infiltrations 28 types cells control samples GSE160170 evaluated by ssGSEA method. Transcription factors (TFs) predicted Transcriptional Regulatory Relationships Unraveled Sentence Based Text Mining (TRRUST) A total 168 overlapping Functional analyses indicated mostly enriched chemokine signaling pathway, regulation actin cytoskeleton, TNF pathway. CytoScape demonstrated 11 hub two cluster modules. infiltration analysis showed significantly upregulated activated CD4 T cells, gamma delta follicular helper cell, CD56dim natural killer eosinophil. TRRUST one TF, RUNX family transcription factor 1. Our pathogenesis with discovered These results may guide future experimental research clinical transformation.

Язык: Английский

Процитировано

0