Clinical Microbiology and Infection, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Фев. 28, 2024
The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social economic burdens on nations. While most of the attention therapeutic efforts have concentrated acute phase disease, a notable proportion survivors experience persistent symptoms post-infection clearance. This diverse set symptoms, loosely categorized as long COVID, presents potential additional public health crisis. It is estimated that 1 5 exhibit clinical manifestations consistent with COVID. Despite this prevalence, mechanisms pathophysiology COVID remain poorly understood. Alarmingly, evidence suggests cases within condition develop debilitating or disabling symptoms. Hence, urgent priority should be given further studies equip systems for its management. review provides an overview available information emerging condition, focusing affected individuals’ epidemiology, pathophysiological mechanisms, immunological inflammatory profiles.
Язык: Английский
Процитировано
21
MedComm – Future Medicine, Год журнала: 2024, Номер 3(4)
Опубликована: Дек. 1, 2024
Abstract Long coronavirus disease (COVID) is characterized by persistent symptoms following severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection and has emerged as a significant health concern. As SARS‐CoV‐2 evolved from the wild‐type strain to Alpha, Beta, Delta, Omicron variants, there may be variant‐specific influence on long COVID akin disease. This review aims summarize our current knowledge of influences in incidence, symptom profile well mechanisms pathogenesis. We highlight that incidence lower with variants. The also show some dependence different reduction cardiopulmonary more recent heterogeneity related differences affecting immune system, viral persistence, autoimmunity. However, emerging data suggest vaccinations play big role shaping presentation COVID. ongoing work profiles populations infected only will beneficial toward useful definitions development effective diagnostic therapeutic strategies.
Язык: Английский
Процитировано
4
JAMA Pediatrics, Год журнала: 2025, Номер unknown
Опубликована: Май 27, 2025
Importance Recent studies have identified characteristic symptom patterns of long COVID (LC) in adults and children older than 5 years. However, LC remains poorly characterized early childhood. This knowledge gap limits efforts to identify, care for, prevent this vulnerable population. Objectives To identify symptoms that had the greatest difference frequency comparing with a history SARS-CoV-2 infection those without, differences types by age group (infants/toddlers [0-2 years] vs preschool-aged [3-5 years]), derive an index can be used research young LC. Design, Setting, Participants was multisite longitudinal cohort study enrollment from over 30 US health community settings, including infants, toddlers, without history. Study data were analyzed May December 2024. Exposure infection. Main Outcomes Measures 41 among infants/toddlers 75 children. Results The included 472 (mean [SD] age, 12 [9] months; 278 infected SARS-CoV-2; 194 uninfected; 234 male [50%]; 73 Black or African American [16%]; 198 Hispanic, Latino, Spanish [43%]; 242 White [52%]) 539 48 [10] 399 140 277 female [51%]; 70 [13%]; 210 [39%]; 287 [54%]). median (IQR) time between first infections completion surveys 318 (198-494) days for 520 (330-844) A derived each based on most associated is calculated summing scores assigned prolonged present, where higher indicate greater magnitude association infection: poor appetite (5 points), trouble sleeping (3.5 wet cough dry (3 stuffy nose (0.5 points) infants/toddlers, daytime tiredness/sleepiness/low energy (6.5 Among infection, 40 (14%) classified as having probable at least 4 points. children, 61 (15%) 3 indices often poorer overall health, lower quality life, perceived delays developmental milestones. Conclusions Relevance distinct 2 groups differed previously ages, demonstrating need characterize separately across ranges.
Язык: Английский
Процитировано
0
European Journal of Pediatrics, Год журнала: 2024, Номер 184(1)
Опубликована: Дек. 21, 2024
Abstract Purpose Lack of a control group(s) and selection bias were the main criticisms previous studies investigating prevalence post-coronavirus disease 2019 (COVID-19) syndrome (PCS). There are insufficient data regarding paediatric PCS, particularly in SARS-CoV-2 Omicron era. As such, our study investigated PCS-associated symptoms representative control-matched cohort. Methods This multicentre, cross-sectional, cohort within “Immunebridge” project German Network University Medicine (NUM) recruited children adolescents (five to 17 years old) between July October 2022. Children with polymerase chain reaction-confirmed infection 2022 (COVID-19 group) compared those without history negative for antibodies. Queries included vaccinations, quality life (QoL), mental physical potentially associated PCS three months. An additional composite item, “physical performance”, was created from responses. Results The number ≥ 1 symptom(s) comparable COVID-19 ( n = 114 [62.1%]) 66 [64.9%]) groups. Concentration disorders reported more frequently group (12.3% versus 1.5%; p 0.012) performance” significantly impaired 0.016) regardless age, sex, vaccination. frequencies other similar both rated their fitness as worse, otherwise equal QoL ratings general health. Conclusion infections did not differ most symptoms. Exceptions performance cognitive problems, which appeared be after than controls. What is Known: • Mainly due too few controlled studies, knowledge about individual post-COVID-19 (PCS) era poor. New: In parent-reported scores PCR-confirmed infection. apparently severely SARS-CoV-2-Omicron subjects.
Язык: Английский
Процитировано
1
Clinical Microbiology and Infection, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1