Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder

EBioMedicine, Год журнала: 2024, Номер 106, С. 105255 - 105255

Опубликована: Июль 19, 2024

Controllability analysis is an approach developed for evaluating the ability of a brain region to modulate function in other regions, which has been found be altered major depressive disorder (MDD). Both symptoms and cognitive impairments are prominent features MDD, but case-control differences controllability between MDD controls can not fully interpret contribution both clinical cognition linked patterns among them MDD.

Язык: Английский

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Predicting treatment outcomes in major depressive disorder using brain magnetic resonance imaging: a meta-analysis

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Язык: Английский

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Brain structural and functional magnetic resonance imaging alterations in individuals with convergence insufficiency

Ophthalmic and Physiological Optics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Purpose Individuals with convergence insufficiency (CI) encounter challenges in turning their eyes inward during near work. It is unclear how this relates to brain structural and functional alterations. This study aimed explore the neural mechanism underlying CI using multimodal magnetic resonance imaging (MRI). Methods Thirty‐four participants 35 healthy controls (HC) were recruited, who underwent visual examinations MRI scanning. Structural data analysed calculate cortical thickness, volume surface area. Fractional amplitude of low‐frequency fluctuation (fALFF) seed‐based connectivity obtained from resting‐state data. The metrics compared between two groups followed by correlation analyses clinical measurements significant features. Results Relative HC, individuals had lower grey matter (GMV) area right frontal eye fields, parietal fields left medial orbitofrontal cortex, higher GMV middle inferior temporal gyri fALFF cerebellum connection bilateral cerebellums. gyrus positively correlated point all participants. Conclusions Lower oculomotor cortices activity may underpin dysfunction fatigue, while reflect partial compensation for cortex defects, thereby maintaining attention parallax information processing. enhance understanding revealing impact abnormal experiences on disassociated alterations vergence system.

Язык: Английский

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Shared and differing functional connectivity abnormalities of the default mode network in mild cognitive impairment and Alzheimer’s disease

Cerebral Cortex, Год журнала: 2024, Номер 34(3)

Опубликована: Март 1, 2024

Abstract Alzheimer’s disease (AD) and mild cognitive impairment (MCI) both show abnormal resting-state functional connectivity (rsFC) of default mode network (DMN), but it is unclear to what extent these abnormalities are shared. Therefore, we performed a comprehensive meta-analysis, including 31 MCI studies 20 AD studies. patients, compared controls, showed decreased within-DMN rsFC in bilateral medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), precuneus/posterior (PCC), right temporal lobes, left angular gyrus increased between DMN inferior gyrus. within mPFC/ACC precuneus/PCC occipital dorsolateral cortex. Conjunction analysis shared precuneus/PCC. Compared MCI, had lobes. share likely underpinning episodic memory deficits neuropsychiatric symptoms, differ alterations related impairments other domains such as language, vision, execution. This may throw light on neuropathological mechanisms two stages dementia.

Язык: Английский

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Neural mechanisms of non-pharmacological interventions in patients with mild cognitive impairment and Alzheimer's disease: An ALE meta-analysis

Experimental Gerontology, Год журнала: 2025, Номер 200, С. 112678 - 112678

Опубликована: Янв. 9, 2025

Язык: Английский

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Neural Activity Alterations and Their Association With Neurotransmitter and Genetic Profiles in Schizophrenia: Evidence From Clinical Patients and Unaffected Relatives

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background The pattern of abnormal resting‐state brain function has been documented in schizophrenia (SCZ). However, as yet, it remains unclear whether this is genetic predisposition or related to the illness itself. Methods A systematical meta‐analysis was performed identify functional differences probands and their high‐risk first‐degree relatives (FDRs‐SCZ) using Seed‐based d Mapping software. Subsequently, spatial associations between postmortem gene expression neurotransmitters distribution data neural activity alterations were conducted uncover mechanisms underlaying FDRs‐SCZ SCZ from a multidimensional perspective. Results total 13 studies comprising 503 605 healthy controls (HCs) 129 6506 patients with 6982 HCs included. Compared HCs, displayed increased spontaneous bilateral anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC); showed decreased ACC/mPFC, postcentral gyrus, right middle temporal gyrus well striatum. altered shared similar genes enriched potassium ion transmembrane transport, channel activity, complex. SCZ‐related patterns additionally associated dopaminergic, serotonergic, cholinergic neurotransmitter distribution. Conclusions functional, neuroimaging transcriptomes, abnormalities may exist unaffected FDRs‐SCZ, rather than just overt SCZ. study extended evidence that function, along correlations genetics systems, associate vulnerability for

Язык: Английский

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Correlations between developmental trajectories of brain functional connectivity, neurocognitive functions, and clinical symptoms in patients with attention-deficit hyperactivity disorder

Journal of Psychiatric Research, Год журнала: 2024, Номер 173, С. 347 - 354

Опубликована: Март 28, 2024

Язык: Английский

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Comparison of arterial spin labeled MRI (ASL MRI) between ADHD and control group (ages of 6–12)

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 28, 2024

Abstract This study utilized arterial spin labeling-magnetic resonance imaging (ASL-MRI) to explore the developmental trajectory of brain activity associated with attention deficit hyperactivity disorder (ADHD). Pulsed labeling (ASL) data were acquired from 157 children ADHD and 109 in a control group, all aged 6–12 years old. Participants categorized into age groups 6–7, 8–9, 10–12, after which comparisons performed between each group for ASL analysis cerebral blood flow (CBF). In total, exhibited significantly lower CBF left superior temporal gyrus right middle frontal regions than group. Further revealed: (1) The comparison (N = 70) 6–7 age-matched 33) showed no statistically significant difference between. (2) However, compared 8–9 39), same 53) postcentral regions. (3) Further, 10–12 34) demonstrated occipital region 37). These age-specific differences suggest variations ADHD-related domains during development post 6–7.

Язык: Английский

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Unsupervised machine learning for identifying attention-deficit/hyperactivity disorder subtypes based on cognitive function and their implications for brain structure

Psychological Medicine, Год журнала: 2024, Номер unknown, С. 1 - 13

Опубликована: Сен. 26, 2024

Abstract Background Structural anomalies in the frontal lobe and basal ganglia have been reported patients with attention-deficit/hyperactivity disorder (ADHD). However, these findings not always consistent because of ADHD diversity. This study aimed to identify subtypes based on cognitive function find their distinct brain structural characteristics. Methods Using data 656 children from Adolescent Brain Cognitive Development (ABCD) Study, we applied unsupervised machine learning using National Institutes Health Toolbox Tasks. Moreover, compared regional volumes between each subtype 6601 without (non-ADHD). Results Hierarchical cluster analysis automatically classified into three subtypes: ADHD-A ( n = 212, characterized by high-order ability), ADHD-B 190, low control, processing speed, episodic memory), ADHD-C 254, strikingly working memory, language ability). analyses revealed that type had significantly smaller left inferior temporal gyrus right lateral orbitofrontal cortex than non-ADHD group, volume was positively correlated performance type. types were different those group. Conclusions These results indicate presence associated deficits Subtype specificity may explain previous inconsistencies ADHD.

Язык: Английский

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Combination of motor, sensory and affective tasks in an EEG paradigm for children with developmental disabilities.

MethodsX, Год журнала: 2024, Номер 13, С. 102997 - 102997

Опубликована: Окт. 10, 2024

Язык: Английский

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