Research progress on the interaction between intestinal flora and microrna in pelvic inflammatory diseases

Non-coding RNA Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Pelvic inflammatory disease (PID) is a common infectious of the female upper reproductive tract, and its pathological basis immune response. The imbalance gut microflora (GM) may lead to development process. A large number studies have shown that fecal microbiota transplantation, probiotics, bacteria, prebiotics, dietary intervention play potential role in remodeling GM treating diseases. MicroRNAs (miRNAs) are involved cell development, proliferation, apoptosis other physiological processes. In addition, they an important process, participating regulation proinflammatory anti-inflammatory pathways. Differences miRNA profiles be PID diagnostic tools serve as prognostic markers disease. relationship between has not been fully elucidated. Recent induction dysbiosis. turn, can regulate expression improve status body. Therefore, this review aims describe interaction PID, find precise targeted therapy for PID.

Язык: Английский

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Features of the clinical course of endometriosis in papillomavirus infection

Journal of obstetrics and women s diseases, Год журнала: 2025, Номер 73(6), С. 172 - 181

Опубликована: Янв. 30, 2025

Background: To date, the etiology and pathogenesis of endometriosis are still unclear determined by a number factors (genetic, immunological endocrine), including microbiological ones. Aim: The aim this study was to characterize clinical course in papillomavirus infection. Materials methods: This retrospective analysis included 185 outpatient records patients with genital comprised complaints, anamnesis data, objective examination, cytological molecular biological examination results. All were divided into two groups. Group 1 (main) consisted human (n = 56), group 2 (comparison) no 129). Results: frequency detection among 30.3 (95% confidence interval 24–38)%. most frequent types detected 31 (20%), 16 (18%), 18 56 (16%), 53 (13%). conclusion cervical examination: following 54/56 had negative for intraepithelial lesion or malignancy (NILM) 2/56 low grade squamous (LSIL), all NILM. average duration 8.2 ± 5.0 years 9.4 5.9 (p 0.15). We found differences between groups respect parameters: age sexual debut 17.82 1.47 18.53 1.43 2, respectively. Dyspareunia occurred 77 63–87)% women Groups 42 33–51)% 0.001). pain severity score according visual analogue scale 6.7 2.4 2.8 points, respectively 0.039). In 1, impaired vaginal microbiocenosis more common. Conclusions: Human every third woman endometriosis, often genotypes high carcinogenic risk. Among features presence papillomavirus, pronounced syndrome symptoms dyspareunia noted. observed.

Язык: Английский

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Unveiling the Mechanisms of Pain in Endometriosis: Comprehensive Analysis of Inflammatory Sensitization and Therapeutic Potential

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1770 - 1770

Опубликована: Фев. 19, 2025

Endometriosis is a complicated, estrogen-dependent gynecological condition with high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women's physical and mental health exacerbates socioeconomic burden. However, specific mechanisms behind occurrence endometriosis-related pain remain unclear. It currently believed that endometriosis related to various factors, such immune abnormalities, endocrine disorders, brain-gut axis, angiogenesis, mechanical stimulation. These factors induce systemic chronic inflammation, which stimulates nerves subsequently alters neural plasticity, leading nociceptive sensitization thereby causing pain. In this paper, we compile review articles published on study mechanisms. Starting from influencing associated explain relationship between these inflammation further elaborate potential by induces sensitization. We aim reveal possible pain, well sensitization, offer new targets for treatment

Язык: Английский

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Managing the neuroinflammatory pain of endometriosis in light of chronic pelvic pain

Expert Opinion on Pharmacotherapy, Год журнала: 2024, Номер 25(17), С. 2267 - 2282

Опубликована: Ноя. 14, 2024

Endometriosis affects 5% to 10% of reproductive age women and may be associated with severely painful debilitating symptoms as well infertility. involves hormonal fluctuations, angiogenesis, neurogenesis, vascular changes neuroinflammatory processes. The component endometriosis makes it a systemic disorder, similar other chronic epithelial inflammatory conditions.

Язык: Английский

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