Mitigation of cadmium toxicity in African catfish using biological Nano chitosan: insights into biochemical, genotoxic, and histopathological effects

BMC Veterinary Research, Год журнала: 2025, Номер 21(1)

Опубликована: Апрель 16, 2025

Abstract Background Cadmium is a highly toxicant heavy metal that poses serious risks to aquatic organisms, animals, and humans. Recent studies have investigated using biological chitosan nanoparticles (Bio-CHNPs) as potential solution alleviate the harmful effects of Cd exposure, particularly in aquaculture. Bio-CHNPs gained attention for their applications drug delivery biomedical research, indicating utility addressing environmental toxicity. Objective This research aims explore effectiveness mitigating cadmium chloride (CdCL 2 ) toxicity African catfish ( Clarias gariepinus). Methods One hundred twenty (n = 120) were divided into 4 groups; G1 (control); G2, intoxicated with 10% LC 50 CdCL ; G3 received 3 g/kg Bio-CNPs; G4, treated Bio-CNPs feed. Results CdCl exposure resulted severe liver, intestine, kidney damage, which was evidenced by alterations biochemical parameters, hormonal imbalance, DNA micronucleus formation. Antioxidant defense mechanisms compromised, activities Superoxide Dismutase (SOD), Total Capacity (TAC), Catalase (CAT) reduced. mRNA expression levels inflammatory cytokines such IL-1β, IL-8, LBP also significantly elevated following exposure. Conversely, treatment showed antioxidant anti-inflammatory effects, greatly lowering biochemical, genotoxic, histopathological induced . Conclusion The outcomes this study are indicative promising aquaculture feed supplement, dual advantage antagonizing pollutants like imparting immunomodulatory effects. Bio-CHNP supplementation can be viable strategy remedying pollution, ultimate safeguarding human health ecosystem balance.

Язык: Английский

A systematic review on the development and efficacy of nano-based vaccine in aquaculture

Aquaculture International, Год журнала: 2025, Номер 33(5)

Опубликована: Май 27, 2025

Язык: Английский