A comprehensive prognostic and immune infiltration analysis of UBA1 in pan‐cancer: A computational analysis and in vitro experiments
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(16)
Опубликована: Авг. 1, 2024
Ubiquitin
like
modifier
activating
enzyme
1
(UBA1)
plays
an
important
role
in
immune
regulation
and
cellular
function.
However,
the
functional
mechanism
of
UBA1
pan-cancer
have
not
been
fully
elucidated
its
value
haematological
tumours
(diffuse
large
B
cell
lymphoma
(DLBC/DLBCL)
acute
myeloid
leukaemia
(AML/LAML))
has
explored.
We
conducted
a
comprehensive
analysis
using
multiple
databases,
including
differential
expression
analysis,
clinical
pathological
staging
prognosis
analysis.
Then,
we
confirmed
function
through
experiments.
The
results
showed
that
was
significantly
increased
most
cancers
mainly
concentrated
digestive
tumours,
brain
tumours.
Moreover,
high
had
poor
which
may
be
related
to
involvement
various
cancer-related
pathways
such
as
cycle,
well
methylation
level,
protein
phosphorylation
infiltration
therapy
response.
Cell
experiments
can
regulate
cycle
progression
apoptosis
DLBCL
cells
AML
cells.
Therefore,
potential
therapeutic
target
for
In
summary,
our
study
only
comprehensively
analysed
mechanisms
pan-cancer,
but
also
validated
first
time
regulatory
Язык: Английский
SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients
APOPTOSIS,
Год журнала:
2024,
Номер
29(9-10), С. 1454 - 1465
Опубликована: Июль 15, 2024
Cuprotosis
related
genes
(CRGs)
have
been
proved
to
be
potential
therapeutic
targets
for
coronavirus
disease
2019
(COVID-19)
and
cancer,
but
their
immune
molecular
mechanisms
in
COVID-19
infection
Diffuse
Large
B-cell
Lymphoma
(DLBC/DLBCL)
patients
are
rarely
reported.
Our
research
goal
is
first
screen
the
key
CRGs
through
univariate
analysis,
machine
learning
clinical
samples.
Secondly,
we
determined
expression
prognostic
role
of
DLBCL
pan-cancer
analysis.
We
validated
levels
prognosis
using
multiple
datasets
independent
samples
functional
cell
experiments.
Finally,
infected
analyzed
common
pathways
DLBCL.
The
results
show
that
synuclein-alpha
(SNCA)
differential
gene
cells
confirm
high
SNCA
can
significantly
promote
apoptosis
inhibit
cycle
progression
High
regulate
binding
major
histocompatibility
complexes
(MHCs)
T
receptor
(TCR)
by
regulating
infiltration
Dendritic
cells,
effectively
enhancing
cell-mediated
anti-tumor
immunity
clearing
cancer
cells.
In
conclusion,
may
a
target
patients.
study
provides
theoretical
basis
improving
treatment
Язык: Английский