The crosstalk between the anterior hypothalamus and the locus coeruleus during wakefulness is associated with low frequency oscillations power during sleep DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

и другие.

Опубликована: Апрель 20, 2025

Abstract Study Objectives Animal research has demonstrated that sleep regulation heavily depends on a network of subcortical nuclei. In particular, whether the crosstalk between Locus Coeruleus (LC) and hypothalamic nuclei influences variability age-related changes in humans remains unexplored. This study investigated effective connectivity LC subparts hypothalamus is associated with electrophysiology rapid eye movement (REMS). Methods Thirty-three healthy younger (∼22y, 27 women) 18 older (∼61y, 14 individuals underwent 7-Tesla functional magnetic resonance imaging during wakefulness to investigate distinct encompassing several Additionally, we recorded their electroencephalogram (EEG) explore relationships measures REMS theta energy sigma power prior episodes. Results The analysis revealed robust evidence mutual positive influence anterior-superior posterior hypothalamus, supporting idea patterns observed animal models are also present humans. Furthermore, our results suggest adults, stronger from including preoptic area, reduced REM energy. Specificity showed this association was not limited but extended specific lower-frequency bands NREMS. Conclusions These findings highlight complex age-dependent modulation circuitry its role regulation. Understanding these neural interactions offers valuable insight into mechanisms driving changes.

Язык: Английский

The crosstalk between the anterior hypothalamus and the locus coeruleus during wakefulness is associated with low frequency oscillations power during sleep DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

и другие.

Опубликована: Апрель 20, 2025

Abstract Study Objectives Animal research has demonstrated that sleep regulation heavily depends on a network of subcortical nuclei. In particular, whether the crosstalk between Locus Coeruleus (LC) and hypothalamic nuclei influences variability age-related changes in humans remains unexplored. This study investigated effective connectivity LC subparts hypothalamus is associated with electrophysiology rapid eye movement (REMS). Methods Thirty-three healthy younger (∼22y, 27 women) 18 older (∼61y, 14 individuals underwent 7-Tesla functional magnetic resonance imaging during wakefulness to investigate distinct encompassing several Additionally, we recorded their electroencephalogram (EEG) explore relationships measures REMS theta energy sigma power prior episodes. Results The analysis revealed robust evidence mutual positive influence anterior-superior posterior hypothalamus, supporting idea patterns observed animal models are also present humans. Furthermore, our results suggest adults, stronger from including preoptic area, reduced REM energy. Specificity showed this association was not limited but extended specific lower-frequency bands NREMS. Conclusions These findings highlight complex age-dependent modulation circuitry its role regulation. Understanding these neural interactions offers valuable insight into mechanisms driving changes.

Язык: Английский

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