European Radiology, Год журнала: 2023, Номер 34(3), С. 1667 - 1676
Опубликована: Сен. 6, 2023
Язык: Английский
Journal of the American College of Cardiology, Год журнала: 2023, Номер 81(9), С. 913 - 923
Опубликована: Фев. 27, 2023
Язык: Английский
Процитировано
34
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Март 29, 2024
Abstract Background Coronary inflammation plays crucial role in type 2 diabetes mellitus (T2DM) induced cardiovascular complications. Both glucose-lowering drug interventions (GLDIS) and glycemic control (GC) status potentially correlate coronary inflammation, as indicated by changes pericoronary adipose tissue (PCAT) attenuation, thus influence risk. This study evaluated the impact of GLDIS GC on PCAT attenuation T2DM patients. Methods retrospective collected clinical data computed tomography angiography (CCTA) images 1,342 patients, including 547 patients 795 non-T2DM two tertiary hospitals. were subgroup based criteria: (1) status: well: HbA1c < 7%, moderate: 7 ≤ 9%, poor: > 9%; (2) non-GLDIS. attenuations left anterior descending artery (LAD-PCAT), circumflex (LCX-PCAT), right (RCA-PCAT) measured. Propensity matching (PSM) was used to cross compare all subgroups Linear regressions conducted evaluate Results Significant differences observed RCA-PCAT LCX-PCAT between poor GC-T2DM (LCX: − 68.75 ± 7.59 HU vs. – 71.93 7.25 HU, p = 0.008; RCA: 74.37 8.44 77.2 7.42 0.026). Higher LAD-PCAT, LCX-PCAT, non-GLDIS compared with (LAD: 78.11 8.01 75.04 8.26 0.022; LCX: 71.10 8.13 68.31 7.90 0.037; 78.17 8.64 73.35 9.32 0.001). In linear regression, other than sex duration diabetes, both metformin acarbose found be significantly associated lower LAD-PCAT (metformin: β coefficient 2.476, =0.021; acarbose: 1.841, 0.031). Conclusion Inadequate management, lack GLDIS, may increased CCTA, leading finding could help healthcare providers identify risk, develop improved management programs, reduce subsequent related mortality.
Язык: Английский
Процитировано
12
British Journal of Radiology, Год журнала: 2023, Номер 96(1145)
Опубликована: Янв. 6, 2023
Pericoronary adipose tissue (PCAT) is the fat deposit surrounding coronary arteries. Although PCAT part of larger epicardial (EAT) depot, it has different pathophysiological features and roles in atherosclerosis process. While EAT evaluation been studied for years, a relatively new concept. PCAT, especially mean attenuation derived from CT images may be used to evaluate inflammatory status arteries non-invasively. The most commonly measure, PCATMA, 3 mm thickness around proximal right artery with length 40 mm. PCATMA can analyzed on per-lesion, per-vessel or per-patient basis. Apart other measures have studied, such as thickness, volume. Studies shown associations between anatomical functional severity disease. associated plaque components high-risk features, discriminate patients flow obstructing stenosis myocardial infarction. Whether value an individual patient basis remains determined. Furthermore, imaging settings, kV levels clinical factors age sex affect measurements, which complicate implementation practice. For widely implemented, standardized methodology needed. This review gives overview reported methodologies current literature potential use cases
Язык: Английский
Процитировано
21
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
9
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Июнь 4, 2024
Abstract Background The purpose of this study was to explore the prognostic significance lesion-specific pericoronary fat attenuation index (FAI) in forecasting major adverse cardiovascular events (MACE) among patients with type 2 diabetes mellitus (T2DM). Methods This conducted a retrospective analysis 304 diagnosed T2DM who underwent coronary computed tomography angiography (CCTA) our hospital from December 2011 October 2021. All participants were followed for period exceeding three years. Detailed clinical data and CCTA imaging features carefully recorded, encompassing FAI, FAI prime arteries, high-risk plaques, artery calcium score (CACS). MACE included comprised cardiac death, acute syndrome (which encompasses unstable angina pectoris myocardial infarction), late-phase revascularization procedures, admissions prompted by heart failure. Results Within three-year follow-up, 76 suffered MACE. experienced notably higher compared those without (–84.87 ± 11.36 Hounsfield Units (HU) vs. –88.65 11.89 HU, p = 0.016). Multivariate Cox regression revealed that CACS ≥ 100 (hazard ratio [HR] 4.071, 95% confidence interval [CI] 2.157–7.683, < 0.001) than − 83.5 HU (HR 2.400, CI 1.399–4.120, independently associated heightened risk over period. Kaplan-Meier showed more likely develop ( 0.0023). Additionally, lesions characterized values found have greater proportion plaques 0.015). Subgroup indicated 2.017, 1.143–3.559, 0.015) correlated moderate severe calcification. Moreover, combination FAI>-83.5 significantly enhanced predictive value within 3 Conclusions elevated emerged as an independent factor T2DM, inclusive Incorporating provided incremental power T2DM.
Язык: Английский
Процитировано
8
Journal of Clinical Hypertension, Год журнала: 2024, Номер 26(4), С. 330 - 337
Опубликована: Март 2, 2024
Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM) patients. The role metformin reducing cardiovascular events well-established, but its effect on coronary artery inflammation T2DM patients still unclear. In this study, we evaluated 547 who underwent computed tomography angiography (CCTA) at Wuhan Central Hospital. Using propensity score matching, compared attenuation pericoronary adipose tissue (PCAT), an imaging marker inflammation, between treated with and without metformin. Multiple linear regression models were used to analyze influence PCAT attenuation. results propensity-matched analysis showed that therapy had significantly lower attenuation, indicating reduced inflammation. Specifically, left anterior descending (LAD) right (RCA) was group non-metformin group. Metformin use independently associated decreased LAD-PCAT multivariate analysis. association differed populations analyzed subgroups obesity chronic kidney disease. conclusion, our study shows a preliminary signal may be patients, as indicated by CCTA. And correlation vary depending patient population. This initial finding suggests could potentially biomarker monitor anti-inflammatory effects medication.
Язык: Английский
Процитировано
7
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Март 28, 2025
Abstract Background Pericoronary adipose tissue attenuation (PCATa), derived from coronary computed tomography angiography (CCTA), is a novel marker of inflammation in the arteries. Patients with type 2 diabetes mellitus (T2DM) are at elevated risk artery disease (CAD), potentially due to systemic inflammation. This study evaluated whether baseline PCATa predicts changes plaque composition and burden over 12 months. Methods prospective longitudinal included 200 participants T2DM, who had neither symptoms nor prior diagnosis CAD (mean age 61 ± 9.4 years, 72% male). was measured scan along proximal 40 mm each major artery, values were averaged calculate participant-level PCATa. High levels determined using validated cut-off -70.1 Hounsfield units. Compositional quantified as differences between 12-month scans, calculated normalized atheroma volume. Multivariable regression analyses assessed associations compositional factors, including high PCATa, predicting non-calcified progression. Results Plaque volumes increased months, while remained stable. After multivariable adjustments, significantly associated total volume (β = 0.005, p 0.005), 0.006, 0.007), 1.7, 2.0, 0.006), but not calcified or burden. observed 44 (22%) only independent predictor progression (odds ratio 3.5, 0.002). Conclusions Baseline increases months T2DM without known CAD. uniquely predict progression, suggesting that may serve for subclinical atherosclerosis warrants further investigation into cardiovascular assessment, particularly high-risk populations such individuals T2DM. Trial registration registration: NCT06644651. Graphical abstract Adipose Tissue attenuation. Type mellitus. Coronary Artery Disease. N numbers. CCTA CT angiography. Created BioRender. Research insights What currently about this topic? (CAD) share inflammatory mechanisms. Individuals face two- four-fold compared those (PCATa) key research question? Can CAD? new? relates higher (NCP) after adjustment. associates total- NCP (> HU) independently How might influence clinical practice? be
Язык: Английский
Процитировано
1
Cardiovascular Intervention and Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Апрель 5, 2025
Язык: Английский
Процитировано
1
Cardiovascular Diabetology, Год журнала: 2023, Номер 22(1)
Опубликована: Янв. 23, 2023
Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to cardiovascular disease, and coronary artery disease (CAD) is their leading cause of death. We aimed assess whether computed tomography (CT) based imaging parameters radiomic features pericoronary adipose tissue (PCAT) can improve the diagnostic efficacy patients T2DM have developed CAD.We retrospectively recruited 229 but no CAD history (146 were diagnosed at this visit 83 not). collected clinical information extracted manifestations from CT images 93 PCAT all patients. All randomly divided into training test groups a ratio 7:3. Four models constructed, encapsulating factors (Model 1), indices 2), Radscore 3), together 4), identify CAD. Receiver operating characteristic curves decision curve analysis plotted evaluate model performance pairwise comparisons performed via DeLong demonstrate additive value different factors.In set, areas under (AUCs) Model 4 0.930 0.929, respectively, higher recognition effectiveness compared other two (each p < 0.001). Of these models, had for than 1 (p 0.001, 95% CI [0.129-0.350]). However, did not identification = 0.776); similarly, AUC significantly differ between 3 (AUC 0.693) 0.691, 0.382). Overall, was rated better diagnosis in T2DM.A comprehensive combining patient risk CT-based has superior diagnosing occurrence T2DM.
Язык: Английский
Процитировано
17
MedComm, Год журнала: 2023, Номер 4(6)
Опубликована: Окт. 24, 2023
Epicardial adipose tissue (EAT) is located between the myocardium and visceral pericardium. The unique anatomy physiology of EAT determines its great potential in locally influencing adjacent tissues such as coronary arteries. Classified by research methodologies, this study reviews latest progress on role cardiovascular diseases (CVDs), particularly patients with metabolic disorders. Studies based imaging techniques demonstrated that increased amount disorders associated higher risk CVDs mortality. Then, in-depth profiling studies indicate remodeled may serve a local mediator deleterious effects cardiometabolic conditions plays crucial CVDs. Further, vitro coculture provided preliminary evidence paracrine effect cardiomyocytes can promote occurrence progression Considering important CVDs, targeting might be strategy to reduce risks. Several interventions have been proved effective reducing amount. Our review provides valuable insights relationship EAT, disorders, well an overview methodological constructs EAT-related studies.
Язык: Английский
Процитировано
17