Ratio of remnant cholesterol to high-density lipoprotein cholesterol in relation to gestational diabetes mellitus risk in early pregnancy among Korean women DOI Creative Commons

Jing Sheng,

Chunfang Ma,

Xiaofei Wu

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0316934 - e0316934

Опубликована: Янв. 3, 2025

Objective There is no evidence to suggest that an association exists between the remnant cholesterol (RC) high-density lipoprotein (HDL-C) ratio and gestational diabetes mellitus (GDM). In this study, RC/HDL-C during first trimester was examined as a potential indicator of onset GDM second trimester. Methods This secondary analysis data from Korea-based prospective cohort study. The study involved 582 women within 14 weeks pregnancy who were November 2014 July 2016 at two Korean hospitals. RC calculated total (TC) minus sum low-density (LDL-C) HDL-C. determined by dividing content HDL-C content. occurrence investigated utilizing binary logistic regression model, various sensitivity analyses, subgroup analyses. Additionally, evaluated using receiver operating characteristic (ROC) analysis. Results average age pregnant 32.07 ± 3.78 years, had median value 0.39. prevalence 6.01%. positive incidence after adjusting for confounding variables (odds ratio: 21.78, 95% confidence interval [CI]: 3.55–133.73, P < 0.001). Furthermore, validated results indicated robust predictor GDM, with area under ROC curve 0.795 (95% CI: 0.723–0.868). optimal threshold 0.45, 71.4% specificity 75.3%. Compared traditional lipid markers, including LDL-C, HDL-C, triglycerides, TC, emerging marker RC, exhibited higher diagnostic efficacy. Conclusion increased risk associated levels 12 gestation, independent factors. more effective in diagnosing than markers.

Язык: Английский

Efferocytosis in atherosclerosis DOI
Shaunak Adkar, Nicholas J. Leeper

Nature Reviews Cardiology, Год журнала: 2024, Номер 21(11), С. 762 - 779

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

38
Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity DOI Creative Commons
Yimin Zhao, Zhenhuang Zhuang, Yueying Li

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 19, 2024

Abstract The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two type 2 diabetes, ischemic heart disease, stroke, has not been definitively established. We aim to examine prospective associations serum remnant cholesterol, triglycerides, risks progression from first disease multimorbidity via multistate modeling in UK Biobank. also evaluate causality these Mendelian randomization using 13 biologically relevant SNPs as genetic instruments. Here we show that elevated cholesterol triglycerides are significantly associated with gradually higher particularly diabetes. These results advocate for effective management a potential strategy mitigating multimorbidity.

Язык: Английский

Процитировано

27
In Vivo Fluorescent Labeling of Foam Cell-Derived Extracellular Vesicles as Circulating Biomarkers for In Vitro Detection of Atherosclerosis DOI

Moxuan Ji,

Yongchun Wei,

Zhuo Ye

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(14), С. 10093 - 10102

Опубликована: Март 28, 2024

Real-time monitoring of the development atherosclerosis (AS) is key to management cardiovascular disease (CVD). However, existing laboratory approaches lack sensitivity and specificity, mostly due dearth reliable AS biomarkers. Herein, we developed an in vivo fluorescent labeling strategy that allows specific staining foam cell-derived extracellular vesicles (EVs) atherosclerotic plaques, which are released into blood as circulating biomarkers for vitro detection AS. This relies on a self-assembled nanoprobe could recognize cells specifically, where probe degraded by intracellular HClO produce trifluoromethyl-bearing boron-dipyrromethene fluorophore (termed B-CF3), lipophilic dye can be transferred exosomal membranes. These B-CF3-stained EVs detected directly fluorescence spectrometer or microplate reader without resorting any sophisticated analytical method. liquid-biopsy format enables early real-time differentiation lesion vulnerability during progression, facilitating effective CVD management.

Язык: Английский

Процитировано

22
Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis DOI Creative Commons
Baoyi Guan, Anlu Wang, Haojie Xu

и другие.

Cardiovascular Diabetology, Год журнала: 2023, Номер 22(1)

Опубликована: Авг. 10, 2023

Emerging evidence suggests that remnant cholesterol (RC) is strongly associated with an increased incidence of cardiometabolic diseases (CMD). However, the causality have not been confirmed. We aimed to evaluate causal associations RC CMD and relative risk factors using two-sample Mendelian randomization (MR) methods.Summary-level statistics RC, CMD, were obtained from published data individuals a predominantly European ancestry mainly UK Biobank FinnGen biobank. Univariable multivariable MR analyses used relationships between CMD. A bidirectional analysis was performed estimate factors. The main method conducted inverse-variance weighted method.Univariable showed genetically predicted causally higher ischemic heart disease, myocardial infarction, atrial fibrillation flutter, peripheral artery non-rheumatic valve (all P < 0.05). Multivariable provided compelling harmful effects on disease (P Bidirectional demonstrated bidirectionally linked total cholesterol, triglycerides, low-density lipoprotein hypercholesterolemia no genetic association found metabolic disorders or other factors.This study demonstrates driven increases several factors, suggesting targeted RC-lowering therapies may be effective for primary prevention

Язык: Английский

Процитировано

25
Association of remnant cholesterol with depression among US adults DOI Creative Commons
Yang Wang,

Ruhua Shen

BMC Psychiatry, Год журнала: 2023, Номер 23(1)

Опубликована: Апрель 17, 2023

Abstract Background Remnant cholesterol is receiving increasing attention because of its association with various diseases. However, there have been no studies on remnant levels and depression. Methods A cross-sectional analysis was performed based the National Health Nutrition Examination Survey (NHANES) 2005–2016. Depression assessed using a Patient Questionnaire (PHQ-9). Fasting calculated as total minus high-density lipoprotein (HDL-C) low-density (LDL-C). Logistic regression sampling weights used to examine between concentration Results Among 8,263 adults enrolled in this study (weighted mean age, 45.65 years), 5.88% percentage) had Compared participants without depression, those depression higher mean, 26.13 vs. 23.05, P < 0.001). There significant positive relationship multivariable-adjusted OR 95% CI 1.49 (1.02–2.17). subgroup analyses, positively associated among less than 60 years (OR, 1.62; CI, 1.09–2.42), male 2.02; 1.01–4.05), BMI under 30 1.83; 1.14–2.96), diabetes 3.88; 1.43–10.49). Conclusions correlated suggesting that focus may be useful

Язык: Английский

Процитировано

24
Remnant cholesterol and risk of incident hypertension: a population-based prospective cohort study DOI

Da-Chuan Guo,

Jing‐Wei Gao, Xiang Wang

и другие.

Hypertension Research, Год журнала: 2024, Номер 47(5), С. 1157 - 1166

Опубликована: Янв. 11, 2024

Язык: Английский

Процитировано

12
Correlation between remnant cholesterol and hyperuricemia in American adults DOI Creative Commons
Xiaohai Zhou,

Xiaolu Weng,

Jing Xu

и другие.

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 8, 2024

Remnant cholesterol (RC) is an important marker for assessing the risk of metabolic syndrome. However, correlation between RC and hyperuricemia (HUA) remains unclear. This study aimed to explore HUA in American adults.

Язык: Английский

Процитировано

10
Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis DOI Creative Commons
Paschalis Karakasis, Dimitrios Patoulias, Manfredi Rizzo

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention management of chronic kidney disease (CKD). Remnant cholesterol (RC), lipoprotein with an established association cardiovascular risk, been investigated context CKD. Given conflicting results from recent studies, we performed this meta‐analysis to summarize existing evidence on between RC Methods Medline, Cochrane Library Scopus were searched until 16 September 2024. Double‐independent study selection, data extraction quality assessment performed. Evidence was pooled using random‐effects meta‐analyses. We set primary end‐point interest Results Twelve studies (4 139 674 participants) included. Participants values highest quantile had significantly greater odds CKD compared those lowest (Odds Ratio [OR] = 1.46, 95% confidence interval [CI] 1.26–1.68). In sensitivity analysis confined subjects type 2 diabetes (T2D), higher also exhibited increased (OR CI 1.20–1.78). A significant inverse observed estimated glomerular filtration rate (Mean Difference [MD] −1.43 mL/min/1.73 m for each 1 mmol/L increase RC, [−2.67, −0.19]). Additionally, individuals T2D‐related 24% risk progression end‐stage renal standard deviation (Hazard [HR] 1.24, 1.04–1.47). Conclusions is directly associated Beyond traditional markers, emphasis should be placed levels or at

Язык: Английский

Процитировано

1
Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder DOI Creative Commons
Ping Xu, Fan Cheng, Mingxing Yan

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Март 4, 2025

Objective The objective of this research was to investigate the relationship between remnant cholesterol (RC) levels and suicide attempts (SA) made by Chinese patients with untreated first-episode major depressive disorder (UFE MDD). Methods This study included 1718 UFE MDD. Demographic, clinical characteristics, blood lipid parameters were collected. 17-item Hamilton Depression Rating Scale (HAMD), 14-item Anxiety (HAMA), positive subscale Positive Negative Syndrome (PANSS) used assess their depression, anxiety, psychotic symptoms, respectively. Multivariable binary logistic regression analysis estimate association RC risk SA. A two-piecewise linear model threshold effects if non-linear associations existed. Results Univariate showed a significant correlation SA, but after controlling for confounding factors, them not statistically significant. After dividing into quartiles, only in Q4 group significantly positively correlated (OR = 1.73, 95% CI: 1.13-2.65, P 0.012, vs. Q1) fully adjusted model. Curve fitting also nonlinear an inflection point at 1.99 mmol/L RC. On left point, observed SA (OR: 1.36, 1.09-1.69, p=0.006). However, on right no found 0.79, 0.55-1.14, p=0.214). Conclusion demonstrates disorder. When less than mmol/L, they correlation.

Язык: Английский

Процитировано

1
Insulin resistance potentiates the effect of remnant cholesterol on cardiovascular mortality in individuals without diabetes DOI
Arsenio Vargas‐Vázquez, Carlos A. Fermín‐Martínez, Neftali Eduardo Antonio‐Villa

и другие.

Atherosclerosis, Год журнала: 2024, Номер 395, С. 117508 - 117508

Опубликована: Март 13, 2024

Язык: Английский

Процитировано

7