Beyond LDL cholesterol: remnant cholesterol is associated with cardiometabolic risk factors in children

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 21, 2025

Язык: Английский

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Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis

Diabetes Obesity and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Background and Aims Adequate lipid control has emerged as a key factor in the prevention management of chronic kidney disease (CKD). Remnant cholesterol (RC), lipoprotein with an established association cardiovascular risk, been investigated context CKD. Given conflicting results from recent studies, we performed this meta‐analysis to summarize existing evidence on between RC Methods Medline, Cochrane Library Scopus were searched until 16 September 2024. Double‐independent study selection, data extraction quality assessment performed. Evidence was pooled using random‐effects meta‐analyses. We set primary end‐point interest Results Twelve studies (4 139 674 participants) included. Participants values highest quantile had significantly greater odds CKD compared those lowest (Odds Ratio [OR] = 1.46, 95% confidence interval [CI] 1.26–1.68). In sensitivity analysis confined subjects type 2 diabetes (T2D), higher also exhibited increased (OR CI 1.20–1.78). A significant inverse observed estimated glomerular filtration rate (Mean Difference [MD] −1.43 mL/min/1.73 m for each 1 mmol/L increase RC, [−2.67, −0.19]). Additionally, individuals T2D‐related 24% risk progression end‐stage renal standard deviation (Hazard [HR] 1.24, 1.04–1.47). Conclusions is directly associated Beyond traditional markers, emphasis should be placed levels or at

Язык: Английский

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Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 17, 2025

This study aimed to examine the relationships between remnant cholesterol (RC) and risk of aortic aneurysm dissection (AAD). prospective cohort included 368,139 European adults from UK Biobank. Additionally, causal relationship RC AAD was investigated using Mendelian randomization (MR) analyses. During a median follow-up 13.65 years, 1,634 cases abdominal (AAA), 698 thoracic (TAA), 184 (AD) were identified. Elevated levels associated with an increased AAA compared reference group ([highest vs. lowest levels]: adjusted hazard ratio (HR) = 1.65, 95% CI: 1.36–1.99). However, no significant association observed high either TAA or AD. Two-sample MR analyses supported effect on (odds (OR) 2.08, 1.70–2.56). The persisted after adjusting for effects RC-associated genetic variants low-density lipoprotein (LDL-C). In contrast, did not indicate any associations linked greater developing AAA, confirming relationship. These findings suggest that may function as new biomarker could be integral strategies at preventing AAA.

Язык: Английский

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Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Март 4, 2025

Objective The objective of this research was to investigate the relationship between remnant cholesterol (RC) levels and suicide attempts (SA) made by Chinese patients with untreated first-episode major depressive disorder (UFE MDD). Methods This study included 1718 UFE MDD. Demographic, clinical characteristics, blood lipid parameters were collected. 17-item Hamilton Depression Rating Scale (HAMD), 14-item Anxiety (HAMA), positive subscale Positive Negative Syndrome (PANSS) used assess their depression, anxiety, psychotic symptoms, respectively. Multivariable binary logistic regression analysis estimate association RC risk SA. A two-piecewise linear model threshold effects if non-linear associations existed. Results Univariate showed a significant correlation SA, but after controlling for confounding factors, them not statistically significant. After dividing into quartiles, only in Q4 group significantly positively correlated (OR = 1.73, 95% CI: 1.13-2.65, P 0.012, vs. Q1) fully adjusted model. Curve fitting also nonlinear an inflection point at 1.99 mmol/L RC. On left point, observed SA (OR: 1.36, 1.09-1.69, p=0.006). However, on right no found 0.79, 0.55-1.14, p=0.214). Conclusion demonstrates disorder. When less than mmol/L, they correlation.

Язык: Английский

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Remnant cholesterol is more positively related to diabetes, prediabetes, and insulin resistance than conventional lipid parameters and lipid ratios: A multicenter, large sample survey

Journal of Diabetes, Год журнала: 2024, Номер 16(8)

Опубликована: Авг. 1, 2024

Abstract Background Not many large‐sample investigations are available that compare the potency of relationship remnant cholesterol (RC) and other lipid parameters with diabetes prediabetes. The goals our study to discover between RC prediabetes, diabetes, insulin resistance (IR) investigate RC, high‐density lipoprotein (HDL‐C), non‐HDL‐C, triglycerides (TG), low‐density (LDL‐C), total (TC), TC/HDL‐C, LDL‐C/HDL‐C, TG/HDL‐C, which most positively related IR. Methods This research enrolled 36 684 subjects from China's eight provinces. We employed multiple logistic regression analysis for testing Results After adjusting potential confounders, comparing results parameters, positive (odds ratio [OR] 1.417, 95% confidence interval [CI]: 1.345–1.492), prediabetes (OR 1.555, CI: 1.438–1.628), IR 1.488, 1.404–1.577) was highest. still even when TG <2.3 mmol/L (diabetes: OR 1.256, 1.135–1.390; prediabetes: 1.503, 1.342–1.684; IR: 1.278, 1.140–1.433), LDL‐C <2.6 1.306, 1.203–1.418; 1.597, 1.418–1.798; 1.552, 1.416–1.701), or HDL‐C ≥1 1.456, 1.366–1.550; 1.553, 1.421–1.697; 1.490, 1.389–1.598). Conclusion is more than conventional lipids ratios in general population, relationships stable, if HDL‐C, LDL‐C, at appropriate levels. image

Язык: Английский

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Remnant cholesterol and mild cognitive impairment: A cross-sectional study

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Март 15, 2023

Objective Emerging evidence suggests that elevated remnant cholesterol (RC) correlates with several health conditions. To explore the association of plasma RC MCI incidence and relationship between different domains cognition in patients. Methods Thirty-six patients 38 cognitively healthy controls (HC) were enrolled present cross-sectional study. Using total (TC) minus high-density lipoprotein (HDL-C) low-density (LDL-C) as formula for calculating fasting RC. Cognition was assessed using Chinese version Montreal cognitive assessment (MoCA), Auditory Verbal Learning Test (AVLT), Digit Symbol Substitution (DSST), Trail Making (TMT), Rey-Osterrieth Complex Figure (ROCF). Results Compared to controls, had a higher level RC, median difference levels these two groups 8.13 mg/dl (95.0%CI: 0.97–16.1). Concurrently, positively associated risk (OR = 1.05, 95%CI: 1.01–1.10). Notably, correlated impaired patients, such DSST ( pr −0.45, p 0.008), ROCF- Long Delayed Recall AVLT-Immediate (pr −0.38, 0.028), TMT-A 0.44, 0.009). Conversely, no significant correlation found AVLT-Long test. Conclusion This study MCI. Further large longitudinal studies are needed future confirm results clarify cause-and-effect relationship.

Язык: Английский

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Remnant Cholesterol, a Valuable Biomarker for Assessing Arteriosclerosis and Cardiovascular Risk: A Systematic Review

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Авг. 27, 2023

Arteriosclerosis, as the foundation for development of cardiovascular diseases, is influenced by disturbances in lipid metabolism. Extensive research has consistently shown a correlation between conventional parameters, arteriosclerosis, and diseases. Guidelines highlight importance targeting low-density lipoprotein cholesterol (LDL-C) primary secondary prevention with reducing LDL-C remaining lipid-lowering strategy. However, even when lowered to optimal levels, there residual risk disease. Recent findings have brought attention remnant (RC) significant factor contributing this risk. The close association RC, diseases presents exciting opportunities lifestyle interventions medical treatments control lower RC offering new targets preventing managing related conditions. Our systematic review sheds light on considering valuable biomarker assessing arteriosclerosis its potential impact health. By understanding link researchers healthcare professionals can develop targeted mitigate risks, thus improving public health outcomes economic burden associated

Язык: Английский

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Higher remnant cholesterol is associated with an increased risk of amnestic mild cognitive impairment: a community-based cross-sectional study

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Фев. 12, 2024

Background and aims Amnestic mild cognitive impairment (aMCI) is the most common subtype of MCI, which carries a significantly high risk transitioning to Alzheimer’s disease. Recently, increasing attention has been given remnant cholesterol (RC), non-traditional previously overlooked factor. The aim this study was explore association between plasma RC levels aMCI. Methods Data were obtained from Brain Health Cognitive Management Team in Wuhan ( https://hbtcm.66nao.com/admin/ ). A total 1,007 community-dwelling elders recruited for project. Based on ten tools including general demographic data, screening some exclusion scales, these participants divided into aMCI n = 401) normal groups 606). Physical examinations conducted all participants, with clinical indicators such as blood pressure, sugar, lipids collected. Results group had higher compared (0.64 ± 0.431 vs. 0.52 0.447 mmol/L, p &lt; 0.05). Binary logistics regression revealed that occupation P &lt;0.001, OR 0.533, 95%CI: 0.423–0.673) 0.014, 1.477, 95% CI:1.081–2.018) associated factors Partial correlation analysis, after controlling occupation, showed significant negative MoCA scores r 0.059, 0.046), well Naming 0.070, 0.026). ROC curve analysis demonstrated an independent predictive efficacy predicting (AUC 0.580, 0.544 ~ 0.615, 0.001). Conclusion Higher identified indicator aMCI, particularly naming domain among older individuals. Further longitudinal studies are necessary validate RC.

Язык: Английский

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Antidiabetic Properties of Stingless Bee Pollen in High-Fat Diet FED-Low Dose STZ Induced Experimental T2DM Rats

Asian Journal of Medicine and Biomedicine, Год журнала: 2024, Номер 8(1), С. 86 - 97

Опубликована: Март 3, 2024

Diabetes mellitus (DM) is a multisystem metabolic disease because of either insulin insufficiency or ineffectiveness. Individuals with DM continuously measure their blood glucose levels during fasting and after eating in order to manage condition effectively. Despite the availability several drugs, there no treatment proven be perfect due adverse side impacts as well reduced long-term efficacy. Moreover, excessive formation free radicals has been linked diabetes progression, development, complications. As result, need explore new medicines without effects, preferably derived from natural products. Therefore, this study analyzes antidiabetic properties stingless bee pollen scientifically. This product was fed high-fat diet low streptozotocin doses experimental rats T2DM. An oral tolerance test aimed investigate effect on homeostasis. toleration executed obtain influence sensitivity. measures Insulin resistance HOMA-IR. Oral administration for 30 days raised homeostasis T2DM rats, shown by OGTT, ITT, HOMA-IR results. In addition, significantly improved changes glycated hemoglobin, glucose, protein, uric acid, urea, creatinine levels. The activity ALP, AST, ALT liver enzyme markers were nearly normalized given pollen. carbohydrate metabolism enzymes includes pyruvate kinase, glucokinase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, fructose-1,6-bisphosphatase lactate dehydrogenase rats’ tissue. change restored near-normal treatment. Keywords: Mellitus, High Fat Diet, Metformin, Stingless Bee Pollen

Язык: Английский

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High remnant-cholesterol levels increase the risk for end-stage renal disease: a nationwide, population-based, cohort study

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 4, 2024

Abstract Background The effect of remnant-cholesterol (remnant-C) on incident end-stage renal disease (ESRD) has not been studied longitudinally. This retrospective cohort study evaluated the association between remnant-C and development ESRD in a nationwide Korean cohort. Methods Participants National Health Insurance Service health examination ( n = 3,856,985) were followed up until onset ESRD. median duration follow-up was 10.3 years. Martin-Hopkins equation used to determine low-density lipoprotein cholesterol (LDL-C) levels from directly measured triglyceride, high-density (HDL-C), total levels. Remnant-C determined by subtracting HDL-C LDL-C cholesterol. risk for calculated each quartile remnant-C, adjusting conventional factors such as baseline function, comorbidities, Results developed 11,073 (0.29%) participants. exhibited gradual increase according higher with 61% increased highest than lowest (hazard ratio [HR] 1.61 [95% confidence interval (CI) 1.50–1.72]). elevated versus more prominent younger older subjects (20–29 years, HR 4.07 CI 2.85–5.83]; 30–39 2.39 1.83–3.13]; ≥ 70 1.32 1.16–1.51]). In addition, related greater females males. Conclusions Independent factors, positively associated ESRD, particularly populations adult females. Reducing may be novel preventive strategy against

Язык: Английский

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