International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113945 - 113945
Опубликована: Дек. 25, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 307 - 307
Опубликована: Янв. 1, 2025
Cataracts remain the leading cause of visual impairment worldwide, yet underlying molecular mechanisms, particularly in age-related cataracts (ARCs), are not fully understood. The Notch signaling pathway, known for its critical role various degenerative diseases, may also contribute to ARC pathogenesis, although specific involvement is unclear. This study investigates regulating ferroptosis lens epithelial cells (LECs) and impact on progression. RNA sequencing anterior capsule samples from patients revealed a significant downregulation signaling, coupled with an upregulation ferroptosis-related genes. Notch1 expression decreased, while markers increased age-dependent manner. In vitro, alleviated by decreasing ferritin heavy chain 1 (FTH1) p53 levels enhancing nuclear factor erythroid 2-related 2 (Nrf2), glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11). Conversely, inhibition exacerbated ferroptosis, as evidenced reduced Nrf2, GPX4, SLC7A11 expression. These findings suggest that promotes LECs impairing Nrf2/GPX4 antioxidant thereby contributing development. offers new insights into pathogenesis highlights pathway potential therapeutic target preventing or mitigating
Язык: Английский
Процитировано
0
BMC Urology, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 18, 2025
Prostate cancer (PCa) is one of the most common malignancies in men worldwide. Despite advances treatment, many patients develop resistance to conventional therapies. Solute carrier (SLC) proteins, as transmembrane transporters, have recently emerged potential therapeutic targets due their role tumor metabolism and progression. This review summarizes key roles six SLC proteins PCa, including involvement metabolic reprogramming, regulation signaling pathways, effects on microenvironment. Although targeting family members prostate remains an underexplored area, growing body evidence suggests that it holds for future development.
Язык: Английский
Процитировано
0
Free Radical Biology and Medicine, Год журнала: 2024, Номер 223, С. 250 - 262
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
4
Journal of Reproductive Immunology, Год журнала: 2025, Номер 168, С. 104447 - 104447
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
0
Redox Biology, Год журнала: 2025, Номер 81, С. 103556 - 103556
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0
Bone Research, Год журнала: 2025, Номер 13(1)
Опубликована: Фев. 25, 2025
Abstract The muscular system plays a critical role in the human body by governing skeletal movement, cardiovascular function, and activities of digestive organs. Additionally, muscle tissues serve an endocrine function secreting myogenic cytokines, thereby regulating metabolism throughout entire body. Maintaining requires iron homeostasis. Recent studies suggest that disruptions ferroptosis, form iron-dependent cell death, are essential contributors to progression wide range diseases disorders, including sarcopenia, cardiomyopathy, amyotrophic lateral sclerosis. Thus, comprehensive overview mechanisms ferroptosis these conditions is crucial for identifying potential therapeutic targets developing new strategies disease treatment and/or prevention. This review aims summarize recent advances understanding molecular underlying context injury, as well associated disorders. Moreover, we discuss within pathway possible managing Finally, shed light on current limitations future prospects interventions targeting ferroptosis.
Язык: Английский
Процитировано
0
Cell Biology International, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
Cardiovascular disease is a circulatory system involving the heart and blood vessels, which one of main causes human health loss even life-threatening. Ca2+ an important signal molecule. Free calcium ions in cytoplasm are involved various physiological biochemical reactions cells. Ferroptosis programmed cell death driven by lipid peroxidation dependent on free ferrous ions. The essence ferroptosis accumulation peroxide caused increase intracellular ion content, leads to damage phospholipid membrane eventually death. Studies have shown that homeostasis occurrence development cardiovascular diseases, but relationship between them remains be clarified. This article reviews pathways regulating cells mechanism ferroptosis, discusses two expected provide novel strategies for alleviating treating diseases.
Язык: Английский
Процитировано
0
International Journal of Immunopathology and Pharmacology, Год журнала: 2025, Номер 39
Опубликована: Март 1, 2025
Excess iron has been associated with cardiovascular diseases. Flavonoids are antioxidants and cardioprotectants. Therefore, the goal of current study is to evaluate anti-apoptotic, antioxidant, iron-chelating qualities two flavonoids, rutin (R) hesperidin (H), as well their potential prevent induced ferroptosis in rats. It an vivo cross-sectional study, which rats were divided into 12 groups; control, H, R, H + Fe, Fe IR, IR Ref, R R. Cardiac serum levels, troponin I, creatine kinase-MB (CK-MB), total binding capacity (TIBC), transferrin, ferritin, hepicidin determined. Moreover, levels malondialdehyde (MDA), nitric oxide (NO) glutathione (GSH) activities superoxide dismutase (SOD) peroxidase (GPx), also The expression DMT1, ACSL4, GPX4, Nrf2, caspase-3 genes evaluated by RT-qPCR. Lastly, a histological analysis heart tissues from several groups was conducted. After and/or treatment, our results revealed that cardiac markers (serum I CK-MB), metabolism iron, TIBC, DMT1 levels) oxidative stress (MDA, NO ACSL4 significantly ( P ⩽ 0.05) reduced, while antioxidant (GSH level, GPx SOD GPX4 Nrf2 increased. Also, exerted its protective anti-apoptotic role decreasing levels. Hesperidin treatment can be proposed therapeutic candidate attenuate ferroptosis.
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
2
International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113177 - 113177
Опубликована: Сен. 18, 2024
Язык: Английский
Процитировано
0