Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 8, 2025

Among hypertensive cohorts across different nations, the relationship between triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence mortality remains be elucidated. This study enrolled 9,283, 164,357, 5,334 hypertensives from National Health Nutrition Examination Survey (NHANES), UK Biobank (UKBB), Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models Mendelian randomization analysis. Mediation analysis explored mediating role of inflammatory markers above relationships. Five measures insulin resistance linked death a U-shaped pattern, highest group having risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was higher all-cause (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: 1.17, 1.00–1.36), 1.36, 1.23–1.49, 1.32, 1.00–1.72) risks. In China cohort, triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) associated risks stroke (HR 1.31, 1.00–1.73 1.67, 1.06–2.63). Inflammation like systemic response (SIRI) C-reactive protein (CRP) partially explained these links, CRP stronger effect. Genetically predicted TyG also (OR 1.26, 1.10–1.45) risk. An elevated indices are significantly correlated an increased three national cohorts. These anticipated serve as valid predictors incident individuals hypertension.

Язык: Английский

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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 7, 2025

Insulin resistance, represented by increased triglyceride-glucose (TyG) index levels, shows interplay with visceral obesity and together promotes cardiovascular diseases mortality. However, significant controversies exist regarding whether modified TyG indices, such as TyG-BMI, TyG-WC, TyG-WHtR, outperform the in predicting outcomes. We aimed to explore there was a synergistic effect of body shape (ABSI), better parameter reflecting obesity, on analyzed data from National Health Nutrition Examination Survey (NHANES) 2001-2018 17,329 individuals. The associations ABSI mortality were investigated via Cox regression analysis restricted cubic splines. Receiver operating characteristic (ROC) curve performed compare predictive value. Mediation used potential mediator. A total 673 (3.9%) deaths occurred during median follow-up 8.92 years. Individuals high (TyG > 9.04 0.085) at highest risk both individuals (HR = 1.714, 95% CI 1.123-2.616) without diabetes 1.402, 1.003-1.960), suggesting effect. Next, we multiplied these two indicators established TyG-ABSI. It showed J-shaped relationship positive linear diabetes, respectively. Arterial stiffness, estimated pulse wave velocity, partially mediated TyG-ABSI mortality, mediation proportion 42.7%. value greater than that index, TyG-WHtR (Harrell's C-index: 0.710 vs 0.623 0.539 0.612 0.622, all p < 0.001). simultaneous assessment revealed recommended use instead other indices assessment.

Язык: Английский

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Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 22, 2025

Insulin resistance (IR) plays a pivotal role in the interplay between metabolic disorders and heart failure with preserved ejection fraction (HFpEF). Various non-insulin-based indices emerge as reliable surrogate markers for assessing IR, including triglyceride-glucose (TyG) index, TyG index body mass (TyG-BMI), atherogenic of plasma (AIP), score insulin (METS-IR). However, ability different IR to predict outcome HFpEF patients has not been extensively explored. Patients having were recruited from January 2012 December 2023. The was defined major adverse cardiovascular event (MACE), encompassing all-cause mortality rehospitalization failure. potential linear relationship visualized by restricted cubic spline (RCS) curve. Both univariable multivariable Cox proportional hazards models employed examine association indexes MACE. Furthermore, assess incremental prognostic value we conducted comprehensive analyses using area under curve (AUC), continuous net reclassification (cNRI), integrated discrimination (IDI). A total 8693 met inclusion criteria included final analysis. mean age 70.59 ± 10.6 years, 5045 (58.04%) being male. Kaplan-Meier survival analysis revealed that higher degree four associated risk MACE (all log-rank P < 0.05). When treated variable, showed significant (HR 2.1, 95% CI 1.98–2.23, 0.001 model 1; HR 1.81, 1.73–1.9, 2; 1.68, 1.6–1.76, 3). categorized into quartiles, highest quartile (Q4) significantly 2.48, 2.24–2.76, Similar associations found TyG-BMI, AIP, METS-IR, enhance stratification capability MAGGIC (AUC 0.601 0.666). compared other indicators, exhibited superior abilities predicting Additionally, TyG-BMI U-shaped correlation MACE, indicating both an elevated lower increased risk. All are independently HFpEF. Notably, these predictive accuracy score, widely used assessment tool Among indices, demonstrated discriminatory abilities, providing greatest exhibiting superiority indices. These findings highlight importance particularly management strategies patients. it should be noted our need validated diverse populations ensure their applicability generalizability.

Язык: Английский

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Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 10, 2025

Abstract Insulin resistance (IR) and abdominal obesity are key in osteoarthritis (OA) development. The triglyceride glucose (TyG) index, along with indicators such as the visceral adiposity index (VAI), lipid accumulation product (LAP), increasingly used to measure IR. This study aims explore associations between surrogate IR indexes OA, assessing their diagnostic efficacy within American populations. included 14,715 adults from National Health Nutrition Examination Survey 2003–2016. Logistic regression models restricted cubic spline were relationship OA. Receiver operating characteristic curves constructed assess of these indices, area under curve (AUC) metric. TyG, triglyceride-waist circumference (TyG-WC), triglyceride-body mass (TyG-BMI), height ratio (TyG-WHtR), VAI LAP significantly positively associated prevalence OA (all p < 0.01). After adjusting for various potential confounders, TyG-WC, TyG-BMI, TyG-WHtR remained correlated Furthermore, revealed a nonlinear association P -non-linear 0.05). indicated that (AUC 0.633) demonstrated more robust efficacy. Additionally, sensitivity analysis produced results consistent primary findings. TyG its combination LAP, showing highest

Язык: Английский

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Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 7, 2025

Cardiovascular autonomic neuropathy (CAN), characterized by disrupted regulation of the cardiovascular system, is a frequent complication associated with diabetes. The triglyceride-glucose (TyG) index represents precise insulin resistance indicator. However, influence baseline and prolonged TyG patterns on CAN risk in type 2 diabetes remains unclear. Based Action to Control Risk Diabetes (ACCORD) trial, multivariate logistic regression models restricted cubic splines (RCS) were deployed for elucidating relation between incidence CAN. area under curve (AUC) receiver operating characteristic (ROC) was used assess diagnostic value predicting relationship trajectory occurrence individuals examined using Kaplan-Meier multivariable Cox proportional hazards model. Subgroup analysis robustness results. Additionally, we explored impact intensive glycemia treatment risk. In this study, these top quartile had greater likelihood developing (TyG Q4 vs. Q1 Model II, OR = 1.29, 95% CI 1.03-1.62, P 0.027). RCS indicated rising trend AUC 0.636 (95% 0.620-0.651; < 0.001), cut-off 0.208. During 7-year follow-up period, three unique trajectories recognized: class 1 (n 431, 23.26%), 798, 27.57%), 3 293, 31.71%). Notable discrepancies across various identified (P 0.001). that experienced comparison those after adjusting all covariates. found no significant effect modification relationship. group, reduced CAN, while an increased when compared standard group. Increased levels long-term are Intensive glycemic therapy might association chance

Язык: Английский

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Predictive value of the triglyceride-glucose index for short- and long-term all-cause mortality in patients with critical coronary artery disease: a cohort study from the MIMIC-IV database

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 22, 2024

Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and valid indicator of insulin resistance. This study evaluated the potential predicting usefulness TyG all-cause mortality, both short- long-term, those concerning critical coronary artery disease (CAD). In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered Medical Information Marketplace Intensive Care (MIMIC-IV) database. Depending on degree, patients categorized into three categories. Clinical outcomes included short-term (30-day) long-term (365-day) mortality. The corresponding relationships involving clinical examined by deploying restricted cubic spline (RCS) regression analysis Cox proportional risk regression. An increased was associated 30-day (Tertile 1: 6.1%, Tertile 2: 7.3%, 3: 9.2%, P = 0.001) 365-day 15.2%, 17.0%, 19.6%, 0.002) death rates across all causes. multiple variables indicates that higher indices all-caused mortality hazard ratios throughout short long terms, larger predictive value former. RCS analyses suggested notably linearly index. reliable predictor at different stages critically ill patients, ability Early intervention elevated may improve their survival outcomes. Future research should delve understanding its pathophysiological mechanisms develop strategies based index, providing new insights enhance outlook patients.

Язык: Английский

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Associations between the intake of single and multiple dietary vitamins and depression risk among populations with chronic kidney disease

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 4, 2025

Background The effects of multivitamin exposure on depression among patients with chronic kidney disease (CKD) have not been thoroughly explored. This study aimed to explore the individual vitamin intakes and joint effect intake multiple vitamins (including A, B 1 , 2 6 12 C, D, E, K) risk in participants CKD. Methods A total 3,123 CKD (weighted n = 25,186,480) from National Health Nutrition Examination Survey database 2007 2014 were included. Weighted multivariate logistic regression models utilized analyze associations dietary risk. Additionally, Bayesian kernel machine (BKMR) weighted quantile sum (WQS) performed evaluate nine Results overall prevalence was approximately 11.3% participants. In fully adjusted model, high (OR: 0.54, 95% CI: 0.40–0.74), 0.67, 0.48–0.95), 0.70, 0.49–0.99), D 0.67. 0.48–0.94), K 0.61, 0.44–0.85) associated a reduced likelihood depression. BKMR WQS showed that had significant negative depression, being largest contributor two models. Lastly, reflected mixed 0.82, 0.69–0.99). Conclusion High are low Furthermore, co-exposure is crucial factor contributing this population.

Язык: Английский

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Relationship between TyG-related index and hearing loss in people over 45 s in China

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 5, 2025

Background Triglycerides and fasting glycemic index are biomarkers used to assess the risk of insulin resistance metabolic syndrome. It its derivatives such as TyG-BMI currently able reflect degree closely related a variety diseases. The relationship between hearing loss remains underexplored, particularly in context aging public health. This study investigates association TyG index, BMI with loss, focus on their potential implications for population. Methods Data from China Health Retirement Longitudinal Study (CHARLS) database were analyzed using R software. We applied multi-factor logistic regression, linear restricted cubic splines, subgroup analyses impact across different age groups. Results was not significantly associated loss. However, both exhibited positive correlation among older individuals. results suggest that population ages, higher indices may increase impairment. Conclusion While does show significant link an increased especially adults. These findings highlight importance considering aging-related factors health initiatives aimed at preventing Further research is needed elucidate mechanisms underlying these associations develop age-inclusive strategies addressing impairment

Язык: Английский

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Association of insulin resistance surrogates with disease severity and adverse outcomes in chronic thromboembolic pulmonary hypertension: a multicenter cohort study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 19, 2025

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severely progressive disease that leads to right heart failure and death. Previous studies have shown diabetes insulin resistance (IR) are closely related hypertension, but the role of IR in patients with CTEPH remains unexplored. In this study, we investigated relationship between four indices severity, hemodynamic parameters, adverse outcomes CTEPH. We conducted multicenter, retrospective cohort study involving 516 diagnosed January 2013 December 2022. The metabolic score for (METS-IR), triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio, glucose (TyG) index, triglyceride-glucose-body mass (TyG-BMI) index were used quantify levels primary endpoint events clinical worsening. Multivariable Cox regression, restricted cubic splines, receiver operating characteristic analyses evaluate predictive value surrogates IR. Compared low intermediate-low risk patients, METS-IR (36.2 ± 6.7 vs. 37.7 8.7, p = 0.038) TyG-BMI (204.0 36.2 212.6 46.5, 0.022) significantly increased high intermediate-high patients. correlated markers such as World Health Organization functional class, 6-minute walk distance, N-terminal pro-brain natriuretic peptide levels. During mean 2.5 years' follow-up, 110 participants experienced all-cause death or worsening condition. independently predicted (hazard ratio: 1.27; 95% confidence interval 1.06–1.53 per 1.0-standard deviation increment, 0.009) after fully adjusting covariates. Adding COMPERA 2.0 improved its ability, reclassification discrimination ability. an independent predictor It offers convenient marker assessing severity long-term assessment.

Язык: Английский

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The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 28, 2025

Triglyceride glucose index (TyG) serves as an effective parameter for assessing metabolic status. However, it remains uncertain whether TyG and other parameters can predict clinical outcomes in people with syndrome (MetS). We investigated the association of TyG, triglyceride glucose-waist to height ratio (TyG-WHtR), score insulin resistance (METS-IR) all-cause cardiovascular mortality MetS cohort determined this changes age. Participants enrolled National Health Nutrition Examination Survey (NHANES) between 2001 2018 were selected categorized into two groups: younger individuals (age < 65 years) older ≥ years). Three new indices TyG-WHtR, METS-IR constructed. The weighted Cox proportional hazards model restricted cubic spline (RCS) models employed evaluate relation three outcomes. time-dependent receiver operating characteristic (ROC) curve assessed ability different mortality. Sensitivity analysis was conducted robustness reliability findings. study comprised a total 8271 participants, including 5456 participants 2815 1407 deaths observed over median follow-up period 8.3 years. Compared first quartile (Q1), fourth quartile's (Q4) linked increased risk (HR 1.63, 95% CI 1.12–2.39; HR 2.78, 1.68–4.61; 1.36, 1.12–2.02, respectively) 2.04, 1.15–4.90; 4.99, 1.76–14.11; 2.69, 1.89–8.15, group but not group. RCS results showed no significant non-linear associations METS-IR, (P = 0.082; P 0.712; 0.062, or 0.176; 0.793; 0.482, age TyG-WHtR demonstrated highest area under predicting 3-year group, values 0.653 0.688 Our highlight predictive value population, providing evidence medical practice public health. A study, 100 months. Weighted COX regression (left), (upper right), (cut-off 36 months) (lower right). index; WHtR ratio; Metabolic resistance; syndrome.

Язык: Английский

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