Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis
Nature Reviews Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Computed Tomography Angiography Identified High-Risk Coronary Plaques: From Diagnosis to Prognosis and Future Management
Diagnostics,
Год журнала:
2024,
Номер
14(15), С. 1671 - 1671
Опубликована: Авг. 1, 2024
CT
angiography
has
become,
in
recent
years,
a
main
evaluating
modality
for
patients
with
coronary
artery
disease
(CAD).
Recent
advancements
the
field
have
allowed
us
to
identity
not
only
presence
of
obstructive
but
also
characteristics
identified
lesions.
High-risk
atherosclerotic
plaques
are
angiographies
via
number
specific
and
may
provide
prognostic
therapeutic
implications,
aiming
prevent
future
ischemic
events
optimizing
medical
treatment
or
providing
interventions.
In
light
new
evidence
safety
efficacy
intervening
high-risk
plaques,
even
non-flow-limiting
disease,
we
aim
comprehensive
review
diagnostic
algorithms
implications
plaque
vulnerability
angiography,
identify
any
differences
invasive
imaging,
analyze
factors
potential
options
such
patients,
as
well
discuss
frontiers,
including
stenoses
role
patient
stratification.
Язык: Английский
Association of sodium–glucose cotransporter-2 inhibitors with mortality across the spectrum of myocardial infarction: a systematic review and meta-analysis
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 22, 2025
Abstract
Background
The
impact
of
sodium–glucose
cotransporter-2
(SGLT2)
inhibitors
on
mortality
following
myocardial
infarction
(MI)
remains
uncertain.
Additionally,
the
role
type
2
diabetes
mellitus
(T2DM)
and
heart
failure
(HF)
in
modulating
effectiveness
these
drugs
post-MI
are
not
fully
understood.
This
meta-analysis
aimed
to
assess
association
SGLT2
with
all-cause
patients
explore
key
moderators
influencing
this
benefit.
Methods
PubMed,
Embase,
Scopus
were
searched
for
randomized
controlled
trials
(RTCs)
propensity
score-matched
(PSM)
observational
studies
assessing
inhibitors'
mortality.
primary
outcome
was
We
pooled
hazard
ratios
(HRs)
estimate
intervention's
effect
overall
population
stratified
into
early
(SGLT2
administered
within
eight
weeks
post-MI)
delayed
treatment
trials.
Meta-regression
assessed
moderating
effects
T2DM
HF.
Results
A
total
five
RCTs
four
PSM
involving
26,753
(mean
[SD]
age,
62.9
[10.5]
years;
6,406
female
[24.0%];
16,369
[61.2%];
13,933
HF
[52.1%])
included.
Early
comprised
16,165
(60.4%)
10,588
(39.6%)
patients,
respectively.
reduced
MI
(HR
0.79,
95%
CI
[0.68,
0.91];
p
=
0.001;
I
59%).
Stratified
analysis
demonstrated
consistent
both
0.76,
[0.59,
0.98];
0.03;
65%)
0.81,
[0.67,
60%)
treatment.
identified
as
a
significant
moderator
benefit
(β
−
0.0049;
0.0006).
Conclusion
In
meta-analysis,
associated
reduction
.
Furthermore,
presence
greater
reduction,
while
significantly
outcome.
Graphical
Association
Inhibitors
Mortality
Across
Spectrum
Myocardial
Infarction.
Data
from
summarized,
including
baseline
characteristics.
plots
represent
confidence
intervals
(CIs),
comparing
control
(placebo/no
treatment),
HRs
below
1
favoring
inhibitors.
diagram
shows
trial
subgroups,
presenting
number
participants,
percentage
receiving
inhibitors,
respective
meta-regression
panel
highlights
moderators,
reporting
β-coefficients
(β),
p-values,
residual
heterogeneity
(I
).
Negative
β
(−)
indicates
that
increases,
HR
decreases.
Abbreviations:
HF,
failure;
MI,
infarction;
SGLT2i,
inhibitors;
T2DM,
mellitus.
Язык: Английский
Association of pericoronary inflammation with atherosclerotic plaque progression in diabetic patients with improved modifiable cardiovascular risk factors: a longitudinal CCTA cohort study
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 25, 2025
Pericoronary
adipose
tissue
(PCAT)
attenuation,
as
assessed
by
coronary
computed
tomography
angiography
(CCTA),
has
been
identified
a
marker
of
pericoronary
inflammation
and
predictor
future
adverse
atherosclerotic
events.
However,
the
impact
changes
in
PCAT
evaluated
consecutive
CCTAs,
on
plaque
progression
high-risk
patients
with
improved
modifiable
cardiovascular
risk
factors
(mCRFs)
remains
unclear.
Consecutive
type
2
diabetes
mellitus
(T2DM)
who
had
mCRFs
underwent
serial,
clinically
indicated
CCTA
examinations
(time
interval
≥
12
months)
at
our
center
between
July
2019
2022
were
screened.
Eligible
participants
least
one
study
plaque,
defined
without
significant
anatomic
stenosis,
located
major
arteries,
which
not
intervened
upon
or
caused
events
serial
scans.
Percent
atheroma
volume
(PAV)
attenuation
measured
for
each
baseline
follow-up
using
analysis
software.
Changes
PAV
(δPAV
=
–
PAV)
compared
based
[δPCAT
attenuation]
(>
0
≤
0).
Multivariate
linear
regression
models
used
to
evaluate
relationship
δPCAT
δPAV.
A
total
98
T2DM
(mean
age:
59.9
years;
75.3%
men;
152
plaques)
that
reached
therapeutic
targets
CCTA.
overall
progressed
from
all
[(41.68
±
12.47)%
vs.
(43.71
12.24)%,
p
0.035],
accompanied
an
increase
(i.e.,
attenuation)
during
median
13.5
months
(interquartile
range
[IQR]:
12.2,
17.5
months).Compared
0,
those
>
significantly
greater
[(4.09
12.09)%
(-0.82
10.74)%,
0.011],
calcified
[1.57%
(IQR:
0.13%,
3.84%)
0.38%
-0.26%,
2.58%),
0.008],
numerical
but
non-significant
non-calcified
[(1.29
11.75)%
(-1.87
10.47)%,
0.089].
demonstrated
increased
was
associated
(β
0.339,
95%
CI:
0.129–0.549),
0.237,
0.019–0.455),
0.109,
0.019-0.200),
independent
age,
sex,
factors,
medications,
(all
<
0.05).
The
effect
elevated
consistent
across
subgroups
interaction
In
this
longitudinal
cohort
mCRFs,
particularly
plaque.
Язык: Английский
Coronary atherosclerotic plaque modification: the present and the future
Expert Review of Cardiovascular Therapy,
Год журнала:
2025,
Номер
23(3), С. 65 - 71
Опубликована: Март 4, 2025
Introduction
Coronary
atherosclerosis,
marked
by
lipid
deposition
and
inflammation,
drives
cardiovascular
morbidity.
Traditional
treatments
focus
on
reduction,
yet
newer
therapies
target
plaque
composition,
aiming
to
enhance
stability
prevent
coronary
events.
Язык: Английский
The Role of Coronary Computed Tomography Angiography in the Diagnosis, Risk Stratification, and Management of Patients with Diabetes and Chest Pain
Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(12)
Опубликована: Дек. 17, 2024
Coronary
artery
disease
(CAD)
affects
over
200
million
individuals
globally,
accounting
for
approximately
9
deaths
annually.
Patients
living
with
diabetes
mellitus
exhibit
an
up
to
fourfold
increased
risk
of
developing
CAD
compared
without
diabetes.
Furthermore,
is
responsible
40
80
percent
the
observed
mortality
rates
among
patients
type
2
typically
present
non-specific
clinical
complaints
in
setting
myocardial
ischemia,
and
as
such,
it
critical
select
appropriate
diagnostic
tests
identify
those
at
major
adverse
cardiac
events
(MACEs)
determining
optimal
management
strategies.
Studies
indicate
that
often
more
advanced
atherosclerosis,
a
higher
calcified
plaque
burden,
smaller
epicardial
vessels.
The
performance
coronary
computed
tomographic
angiography
(CCTA)
identifying
significant
stenosis
well-established,
CCTA
has
been
incorporated
into
current
guidelines.
However,
predictive
accuracy
obstructive
less
extensively
characterized.
provides
detailed
insights
anatomy,
vessel
stenosis,
high-risk
features,
other
features
associated
incidence
MACEs.
Recent
evidence
supports
efficacy
diagnosing
improving
patient
outcomes,
leading
its
recommendation
primary
tool
stable
angina
stratification.
specific
benefits
require
further
elucidation.
This
review
examines
several
key
aspects
utility
diabetes:
(i)
detecting
CAD,
(ii)
effect
first-line
test
individualized
stratification
cardiovascular
(iii)
role
guiding
therapeutic
management,
(iv)
future
perspectives
artificial
intelligence.
Язык: Английский