AIP, fatty liver, and HbA1c as modifiers of the C-index and diabetes risk relationship DOI Creative Commons
Yanmei Liu, Rui Shi, Huiying Cao

и другие.

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 2, 2025

Abstract Background and aims Recent studies have suggested an interplay between conicity index (C-index)-related diabetes risk lipid burden. It is plausible that the atherogenic of plasma (AIP), fatty liver, HbA1c mediate association C-index risk, though this has not been fully explored. This study explored whether AIP, relationship as well their combined effect. Methods Data from 15,453 participants in NAGALA Cohort were analyzed (median follow-up 5.39 years). Restricted Cubic Spline (RCS) univariate Cox regression models adjusted for factors used to assess role AIP modifying C-index-diabetes relationship. Mediation analysis assessed contributing factors, predictive established. Results Among normoglycemic individuals, remained significantly positively associated with risk. Higher levels strengthened association, particularly range 0.11-≤1.21. In initial model, hazard ratios (HRs) those fourth quartile distribution group showed a significant HR 2.22 (1.37–3.59). As liver progressively adjusted, HRs gradually decreased, but 1.70 (1.05–2.76) was retained model. No observed other strata. Furthermore, mediated mediation effects 9.8%, 25.0%, 13.4%, respectively. Notably, model incorporating HbA1c, achieved highest performance (AUC = 0.86), outperforming alone 0.68). Conclusions modified by HbA1c. These findings emphas ize importance along C-index, context screening management.

Язык: Английский

Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study DOI Creative Commons

Tongshuai Wang,

Mengru Zhang, Wenxing Shi

и другие.

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 5, 2025

The atherogenic index of plasma (AIP) and systematic inflammation, as measured by high-sensitivity C-reactive protein (hsCRP), are predictors diabetes, but their combined impacts on incident diabetes poorly understood. Using a nationally representative cohort in China, we aimed to investigate the association AIP hsCRP with among middle-aged elderly adults. This comprised 9,112 participants aged at least 45 years from 125 cities China Health Retirement Longitudinal Study who were free baseline 2011. Of these, 5,048 followed up until 2015. was calculated Log10[TG (mg/dL)/HDL-C(mg/dL)]. Multivariate logistic regression linear mixed-effect (LME) models performed evaluate associations AIP, hsCRP, well glycemic biomarkers. Receiver operating characteristic (ROC) curves used diagnostic values. We conducted mediation analysis assess direct indirect between diabetes. 489 (9.7%) cases developed during four years. Higher levels independently associated Compared lowest quartile or highest (adjusted odds ratio, aOR 2.53, 95% CI: 1.90-3.38) (aOR 2.38, 1.79-3.16) significantly joint effects showed that higher had 2.76 (2.13-3.57). LME related an increased level fasting blood glucose glycated hemoglobin. combination has better predictive efficacy (area under curve, AUC: 0.628, 0.601-0.654) for than alone. Mediation analyses high mediated 25.4% simultaneously 5.7% suggests mutual China. Our findings provide clinical implications monitoring managing mitigate development

Язык: Английский

Процитировано

0
AIP, fatty liver, and HbA1c as modifiers of the C-index and diabetes risk relationship DOI Creative Commons
Yanmei Liu, Rui Shi, Huiying Cao

и другие.

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 2, 2025

Abstract Background and aims Recent studies have suggested an interplay between conicity index (C-index)-related diabetes risk lipid burden. It is plausible that the atherogenic of plasma (AIP), fatty liver, HbA1c mediate association C-index risk, though this has not been fully explored. This study explored whether AIP, relationship as well their combined effect. Methods Data from 15,453 participants in NAGALA Cohort were analyzed (median follow-up 5.39 years). Restricted Cubic Spline (RCS) univariate Cox regression models adjusted for factors used to assess role AIP modifying C-index-diabetes relationship. Mediation analysis assessed contributing factors, predictive established. Results Among normoglycemic individuals, remained significantly positively associated with risk. Higher levels strengthened association, particularly range 0.11-≤1.21. In initial model, hazard ratios (HRs) those fourth quartile distribution group showed a significant HR 2.22 (1.37–3.59). As liver progressively adjusted, HRs gradually decreased, but 1.70 (1.05–2.76) was retained model. No observed other strata. Furthermore, mediated mediation effects 9.8%, 25.0%, 13.4%, respectively. Notably, model incorporating HbA1c, achieved highest performance (AUC = 0.86), outperforming alone 0.68). Conclusions modified by HbA1c. These findings emphas ize importance along C-index, context screening management.

Язык: Английский

Процитировано

0