Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 17, 2023
Numerous
microorganisms
and
other
invertebrates
that
are
able
to
degrade
polyethylene
(PE)
have
been
reported.
However,
studies
on
PE
biodegradation
still
limited
due
its
extreme
stability
the
lack
of
explicit
insights
into
mechanisms
efficient
enzymes
involved
in
metabolism
by
microorganisms.
In
this
review,
current
biodegradation,
including
fundamental
stages,
important
enzymes,
functional
microbial
consortia,
were
examined.
Considering
bottlenecks
construction
PE-degrading
a
combination
top-down
bottom-up
approaches
is
proposed
identify
metabolites
degradation,
related
synthetic
consortia.
addition,
exploration
plastisphere
based
omics
tools
as
future
principal
research
direction
for
consortia
degradation.
Combining
chemical
biological
upcycling
processes
waste
could
be
widely
applied
various
fields
promote
sustainable
environment.
Chemical Reviews,
Год журнала:
2022,
Номер
123(5), С. 2349 - 2419
Опубликована: Дек. 13, 2022
Recent
advances
in
synthetic
biology
and
materials
science
have
given
rise
to
a
new
form
of
materials,
namely
engineered
living
(ELMs),
which
are
composed
matter
or
cell
communities
embedded
self-regenerating
matrices
their
own
artificial
scaffolds.
Like
natural
such
as
bone,
wood,
skin,
ELMs,
possess
the
functional
capabilities
organisms,
can
grow,
self-organize,
self-repair
when
needed.
They
also
spontaneously
perform
programmed
biological
functions
upon
sensing
external
cues.
Currently,
ELMs
show
promise
for
green
energy
production,
bioremediation,
disease
treatment,
fabricating
advanced
smart
materials.
This
review
first
introduces
dynamic
features
systems
potential
developing
novel
We
then
summarize
recent
research
progress
on
emerging
design
strategies
from
both
perspectives.
Finally,
we
discuss
positive
impacts
promoting
sustainability
key
future
directions.
Biotechnology Advances,
Год журнала:
2024,
Номер
74, С. 108401 - 108401
Опубликована: Июнь 27, 2024
Metabolic
burden
is
defined
by
the
influence
of
genetic
manipulation
and
environmental
perturbations
on
distribution
cellular
resources.
The
rewiring
microbial
metabolism
for
bio-based
chemical
production
often
leads
to
a
metabolic
burden,
followed
adverse
physiological
effects,
such
as
impaired
cell
growth
low
product
yields.
Alleviating
imposed
undesirable
changes
has
become
an
increasingly
attractive
approach
constructing
robust
factories.
In
this
review,
we
provide
brief
overview
engineering,
focusing
specifically
recent
developments
strategies
diminishing
while
improving
robustness
yield.
A
variety
examples
are
presented
showcase
promise
engineering
in
facilitating
design
construction
Finally,
challenges
limitations
encountered
discussed.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(2), С. 217 - 217
Опубликована: Фев. 18, 2024
Infectious
diseases
have
long
posed
a
significant
threat
to
global
health
and
require
constant
innovation
in
treatment
approaches.
However,
recent
groundbreaking
research
has
shed
light
on
previously
overlooked
player
the
pathogenesis
of
disease-the
human
microbiome.
This
review
article
addresses
intricate
relationship
between
microbiome
infectious
unravels
its
role
as
crucial
mediator
host-pathogen
interactions.
We
explore
remarkable
potential
harnessing
this
dynamic
ecosystem
develop
innovative
strategies
that
could
revolutionize
management
diseases.
By
exploring
latest
advances
emerging
trends,
aims
provide
new
perspective
combating
by
targeting
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июль 5, 2022
Synthetic
microbial
consortia
represent
a
new
frontier
for
synthetic
biology
given
that
they
can
solve
more
complex
problems
than
monocultures.
However,
most
attempts
to
co-cultivate
these
artificial
communities
fail
because
of
the
winner-takes-all
in
nutrients
competition.
In
soil,
multiple
species
coexist
with
spatial
organization.
Inspired
by
nature,
here
we
show
an
engineered
segregation
method
assemble
stable
both
flexibility
and
precision.
We
create
swarmbot
(MSBC)
encapsulating
subpopulations
polymeric
microcapsules.
The
crosslinked
structure
microcapsules
fences
microbes,
but
allows
transport
small
molecules
proteins.
MSBC
enables
assembly
various
precise
control
over
subpopulations.
These
capabilities
readily
modulate
division
labor
communication.
Our
work
integrates
material
science
offer
insights
into
serve
as
foundation
diverse
applications
from
biomanufacturing
photosynthesis.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 10, 2023
Plant
Growth
Promoting
Rhizobacteria
(PGPR)
has
gained
immense
importance
in
the
last
decade
due
to
its
in-depth
study
and
role
of
rhizosphere
as
an
ecological
unit
biosphere.
A
putative
PGPR
is
considered
only
when
it
may
have
a
positive
impact
on
plant
after
inoculation.
From
various
pieces
literature,
been
found
that
these
bacteria
improve
growth
plants
their
products
through
growth-promoting
activities.
microbial
consortium
effect
(PGP)
activities
evident
by
literature.
In
natural
ecosystem,
rhizobacteria
interact
synergistically
antagonistically
with
each
other
form
consortium,
but
there
are
oscillating
environmental
conditions
affect
potential
mechanism
consortium.
For
sustainable
development
our
environment,
utmost
necessity
maintain
stability
rhizobacterial
fluctuating
conditions.
decade,
studies
conducted
design
synthetic
helps
integrate
cross-feeding
over
strains
reveal
social
interactions.
this
review,
authors
emphasized
covering
all
designing
consortiums,
strategies,
mechanism,
application
field
ecology
biotechnology.
Nature Chemical Biology,
Год журнала:
2023,
Номер
19(8), С. 951 - 961
Опубликована: Май 29, 2023
Abstract
Nutritional
codependence
(syntrophy)
has
underexplored
potential
to
improve
biotechnological
processes
by
using
cooperating
cell
types.
So
far,
design
of
yeast
syntrophic
communities
required
extensive
genetic
manipulation,
as
the
co-inoculation
most
eukaryotic
microbial
auxotrophs
does
not
result
in
cooperative
growth.
Here
we
employ
high-throughput
phenotypic
screening
systematically
test
pairwise
combinations
auxotrophic
Saccharomyces
cerevisiae
deletion
mutants.
Although
coculture
pairs
do
enter
growth,
identify
49
that
spontaneously
form
syntrophic,
synergistic
communities.
We
characterized
stability
and
growth
dynamics
nine
cocultures
demonstrated
a
pair
tryptophan
grow
exchanging
pathway
intermediate
rather
than
end
products.
then
introduced
malonic
semialdehyde
biosynthesis
split
between
different
auxotrophs,
which
resulted
increased
production.
Our
results
report
spontaneous
formation
stable
syntrophy
S.
illustrate
dividing
labor
intraspecies
community.
The Microbe,
Год журнала:
2024,
Номер
4, С. 100117 - 100117
Опубликована: Июль 4, 2024
Bacterial
cells
produce
a
variety
of
exopolysaccharide
(EPS)
throughout
their
life
cycle.
EPS
plays
crucial
role
in
the
formation
biofilms
and
control
environmental
processes
microbial
communities.
The
bacterial
community
benefits
from
several
ways,
including
nutrient
compartmentation
storage,
stress
resistance
synergism.
generation
by
consortium-associated
bacteria,
which
involves
microorganisms,
is
versatile
efficient
for
use
industrial
processes,
such
as
biotechnology
pollution
degradation.
qualitative
quantitative
chemical
characteristics
consortium's
are
mostly
determined
type
culture
utilized,
type,
temperature,
pH.
main
goal
study
was
to
find
out
how
biosynthesis
works
consortium
culture.
To
achieve
maximum
regeneration,
pH,
carbon,
nitrogen
sources
were
optimized.
A
three
strains
i.e.
Klebsiella
pneumonia
strain,
Pseudomonas
aeruginosa
strain
Burkholderia
cepacian
that
distinguished
capacity
developed
part
study.
total
production
detected
after
8
days
incubation
at
pH
7.5
(15.5
g/L)
temperature
35
°C
(12.60
g/L).
optimum
identified
17.84
g/L
21.07
when
ammonium
sulfate
glucose
employed
carbon
supplements,
respectively.
protein
concentration
3067
µg/mL,
more
than
carbohydrate
(263.10
µg/mL)
DNA
(7.60
content.
protein/carbohydrate
ratio
present
11.65,
much
higher
prior
investigations.
FTIR
analysis
confirmed
functional
groups
carbohydrates,
proteins,
lipids
DNA,
viz.,
CO,
COOH,
NH,
OH,
CH
OCH3.
study's
findings
revealed
enhancing
molecules
lowering
biofilm-related
infections
improving
efficacy
antimicrobial
treatments
wastewater.
Journal of Sustainable Agriculture and Environment,
Год журнала:
2024,
Номер
3(3)
Опубликована: Сен. 1, 2024
Abstract
Sustainable
increase
in
agriculture
productivity
is
confronted
by
over‐reliance
and
over‐use
of
synthetic
chemical
fertilizers.
With
a
market
projection
$5.02
billion
2030,
biofertilizers
are
gaining
momentum
as
supplement
and,
some
cases,
an
alternative
to
Biofertilizers
can
improve
the
nutritional
supply
plant
simultaneously
soil
health,
reduce
greenhouse
emissions,
hence
directly
contribute
towards
environmental
sustainability.
Plant
growth‐promoting
microbes
(PGPMs)
particularly
receiving
significant
attention
biofertilizers.
They
widely
known
for
their
ability
growth
via
increasing
nutrient
availability
use
efficiency.
However,
except
few
successful
commercialization
PGPM‐based
inoculants
still
limited,
mainly
due
lack
field
efficacy
consistency.
Lack
effective
formulation
technologies
that
keep
microbial
viable
during
storage,
transport
application
considered
one
key
factors
drive
inconsistent
In
this
review,
we
identify
current
challenges
associated
with
inoculants.
We
propose
future
paths,
including
advancement
potentially
efficient,
eco‐friendly
cost‐effective.
argue
enhance
global
adoption
biofertilizers,
new
innovations
based
on
transdisciplinary
approaches
indispensable.
The
emerging
framework
should
encompass
robust
quality
control
system
at
all
stages.
Additionally,
active
partnership
between
academic
industry
stakeholders
will
pave
way
enhanced
