ROS: A “booster” for chronic inflammation and tumor metastasis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(6), С. 189175 - 189175
Опубликована: Авг. 31, 2024
Язык: Английский
Emerging Potential of Metabolomics in Thyroid Cancer—A Comprehensive Review
Cancers,
Год журнала:
2025,
Номер
17(6), С. 1017 - 1017
Опубликована: Март 18, 2025
Thyroid
cancer
is
a
very
common
endocrine
system
malignancy.
Nevertheless,
dearth
of
precise
markers
makes
it
challenging
to
apply
precision
medicine
thyroid
cancer.
The
limitations
standard
diagnosis
techniques
(fine-needle
aspiration
biopsy),
such
as
indeterminate
cases
and
inaccuracies
in
distinguishing
between
different
types
cancers,
lead
unnecessary
surgeries
thus
warrant
the
development
more
discriminatory
biomarkers
improve
accuracy
existing
diagnostic
prognostic
techniques.
Moreover,
individualized
therapies
for
are
necessary
avoid
overtreatment
indolent
lesions
undertreatment
high-risk
progressive
disease.
As
metabolic
signatures
associated
with
disease
aggressiveness
responsiveness
therapy,
metabolomics
has
been
recently
used
biomarker
discovery.
This
strategy
enabled
detection
several
metabolites
from
tissue
samples
or
biofluids
facilitate
classification
potentially
assist
therapies.
In
this
review,
we
summarize
utilization
potential
Язык: Английский
Tissue Inhibitor of Metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis
Journal of Biological Chemistry,
Год журнала:
2025,
Номер
unknown, С. 108473 - 108473
Опубликована: Апрель 1, 2025
Tissue
inhibitor
of
metalloproteinase
1
(TIMP1)
has
been
implicated
in
prostate
cancer
metastasis.
In
this
study,
PC-3M-2B4
cells
with
TIMP1
knockdown
(PC-3M-2B4-shTIMP1)
or
over-expression
(PC-3M-2B4-TIMP1)
were
generated
and
an
inverse
correlation
was
found
between
expression
cell
migration
invasion
which
confirmed
vitro
vivo.
Differential
accompanied
by
variations
the
ferroptosis-related
proteins,
glutathione
peroxidase
4
(GPX4),
transferrin
receptor
(TFRC),
(TF),
glutamine
cysteine
ligase
catalytic
subunit
(GCLC)
modifier
(GCLM).
comparison
TIMP1-overexpressing
cells,
TIMP1-knockdown
demonstrated
a
12.3%
decrease
Fe2+
concentration
after
erastin
treatment,
37.8%
reduction
malondialdehyde
(MDA)
levels,
113.7%
increase
GPX4
expression,
78.9%
rise
GSH/GSSG
ratio.
Our
findings
indicate
that
overexpression
promotes
ferroptosis
modulating
critical
markers
such
as
TFRC,
thereby
significantly
reducing
metastatic
potential
cells.
results
highlight
TIMP1's
role
regulating
pathways,
are
crucial
for
tumor
progression,
exposes
therapeutic
target
management.
Язык: Английский
Potential regulation of certain genes at the transcription level for ferroptosis evasion in triple-negative breast cancer (TNBC): A hypothesis
Medical Hypotheses,
Год журнала:
2024,
Номер
189, С. 111413 - 111413
Опубликована: Июнь 30, 2024
Язык: Английский
The Potential Role of Non-coding RNAs in Regulating Ferroptosis in Cancer: Mechanisms and Application Prospects
Ming-Yuan Cao,
Zhendong Zhang,
Xin-Rui Hou
и другие.
Anti-Cancer Agents in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(16), С. 1182 - 1196
Опубликована: Июль 18, 2024
:
Cancer
is
the
second
leading
cause
of
death
globally.
Despite
some
successes,
conventional
cancer
treatments
are
insufficient
to
address
growing
problem
drug
resistance
in
tumors
and
achieve
efficient
treatment
outcomes.
Therefore,
there
an
urgent
need
explore
new
therapeutic
options.
Ferroptosis,
a
type
iron-
reactive
oxygen
species-dependent
regulated
cell
death,
has
been
closely
associated
with
development
progression.
Non-coding
RNAs
(ncRNAs)
class
that
do
not
code
for
proteins,
studies
have
demonstrated
their
involvement
regulation
ferroptosis
cancer.
This
review
aims
molecular
regulatory
mechanisms
ncRNAs
involved
emphasize
feasibility
as
novel
strategies
We
conducted
systematic
extensive
literature
using
PubMed,
Google
Scholar,
Web
Science,
various
other
sources
identify
relevant
on
ferroptosis,
ncRNAs,
A
deeper
understanding
could
facilitate
strategies.
Язык: Английский