CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression DOI Creative Commons
Wei Yan, Guohui Xiao, Lijuan Wang

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 16, 2025

The stiffness of the matrix is closely related to progression hepatocellular carcinoma (HCC). Although direct targeting stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs) are considered key contributors this process. Given heterogeneity CAFs, study explored relationship between specific CAF subsets and liver cancer stiffness, aiming identify novel therapeutic targets for patients. Single-cell sequencing datasets were leveraged cell types within characterize transcriptomic profiles CAFs. Prognostic analysis, utilizing Gene Expression Profiling Interactive Analysis (GEPIA) Cancer Genome Atlas (TCGA) datasets, assessed correlation stiffness-related genes patient outcomes. Pseudo-time analysis was applied trace developmental trajectories By calculating intercellular communication probabilities analyzing transcription factor activity, functions interactions different elucidated. Ontology (GO) used explore functional roles CAFs distinct Yes-associated protein 1 (YAP1) groups. Finally, cellular experiments animal further conducted validate hypotheses study. This identified subpopulations based on single-cell data analyzed transcriptional changes these subpopulations. Key findings include identification collagen type I alpha (COL1A1), III (COL3A1), lysyloxidase (LOX) as pivotal node during development. Moreover, expression inversely correlated with prognosis Notably, YAP1-positive subpopulation emerged primary contributor cancer. upregulates promotes tumor by activating signaling pathways such autophagy GTPase activity regulation. Cellular studies validated conclusion. uncovered subpopulation, particular, shown contribute upregulating relevant promoting through activation pathways.

Язык: Английский

The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies DOI Creative Commons
Ujjawal Sharma,

Anidrisha Sahu,

Himanshu Shekhar

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Extracellular matrix and pregnancy: functions and opportunities caught in the net DOI Creative Commons

Francesca Rossi,

Stefania Luppi, Albina Fejza

и другие.

Reproductive Biology and Endocrinology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 14, 2025

The extracellular matrix is a complex network of macromolecules that support the growth and homeostatic development organisms. By conveying multiple signaling cascades, it impacts on several biological processes influences behaviour numerous cell types. During endometrial cycle key events necessary for correct embryo implantation placentation, this bioactive meshwork substantially modified to favour receptivity vascular adaptation, trophoblast migration, immune activation as well. A remodeling fundamental establishment physiological pregnancy; indeed, occurrence altered modifications associates with gestational disorders such preeclampsia. In present review, we will critically evaluate role pivotal constituents in regulating steps provide up-to-date information concerning their primary mechanisms action discuss potential novel source biomarkers therapeutic targets.

Язык: Английский

Процитировано

0
Role of Soluble Cytokine Receptors in Gastric Cancer Development and Chemoresistance DOI Open Access
Francesco Severini, Geppino Falco, Tiziana Notarangelo

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2534 - 2534

Опубликована: Март 12, 2025

Gastric cancer is among the top five most important malignancies in world due to high burden of disease and its lethality. Indeed, it fourth common cause death worldwide, characterized by a poor prognosis low responsiveness chemotherapy. Multidrug resistance limits clinical management patient. Among these, role chronic activation inflammatory pathways underlying gastric tumorigenesis should be highlighted. Furthermore, immunosuppressive TME influences response therapy. This review discusses soluble cytokine receptors development chemoresistance cancer, considered as molecular marker target strategies overcome resistance.

Язык: Английский

Процитировано

0
Prognostic Value of P4HA2 Expression in Malignancies: A Meta-Analysis of Survival Outcomes and Clinicopathological Features DOI

Jianhua Liao,

Jingting Liu, Jun Cheng

и другие.

Indian Journal of Surgery, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
Translational Advances in Oncogene and Tumor-Suppressor Gene Research DOI Open Access
Radoslav Stojchevski,

Edward Agus Sutanto,

R. Sutanto

и другие.

Cancers, Год журнала: 2025, Номер 17(6), С. 1008 - 1008

Опубликована: Март 17, 2025

Cancer, characterized by the uncontrolled proliferation of cells, is one leading causes death globally, with approximately in five people developing disease their lifetime. While many driver genes were identified decades ago, and most cancers can be classified based on morphology progression, there still a significant gap knowledge about genetic aberrations nuclear DNA damage. The study two critical groups genes—tumor suppressors, which inhibit promote apoptosis, oncogenes, regulate survival—can help to understand genomic behind tumorigenesis, more personalized approaches diagnosis treatment. Aberration tumor undergo two-hit loss-of-function mutations, activated forms proto-oncogenes that experience one-hit gain-of-function are responsible for dysregulation key signaling pathways cell division, such as p53, Rb, Ras/Raf/ERK/MAPK, PI3K/AKT, Wnt/β-catenin. Modern breakthroughs genomics research, like next-generation sequencing, have provided efficient strategies mapping unique changes contribute heterogeneity. Novel therapeutic enabled medicine, helping address variability suppressors oncogenes. This comprehensive review examines molecular mechanisms tumor-suppressor they regulate, epigenetic modifications, heterogeneity, drug resistance drive carcinogenesis. Moreover, explores clinical application sequencing techniques, multiomics, diagnostic procedures, pharmacogenomics, treatment prevention options, discussing future directions emerging technologies.

Язык: Английский

Процитировано

0
Exploring TGF-β signaling in benign prostatic hyperplasia: from cellular senescence to fibrosis and therapeutic implications DOI

Abida Khan,

Hayat Alzahrani, Shatha Ghazi Felemban

и другие.

Biogerontology, Год журнала: 2025, Номер 26(2)

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
CAFs activated by YAP1 upregulate cancer matrix stiffness to mediate hepatocellular carcinoma progression DOI Creative Commons
Wei Yan, Guohui Xiao, Lijuan Wang

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 16, 2025

The stiffness of the matrix is closely related to progression hepatocellular carcinoma (HCC). Although direct targeting stromal rigidity in HCC remains a clinical challenge, cancer-associated fibroblasts (CAFs) are considered key contributors this process. Given heterogeneity CAFs, study explored relationship between specific CAF subsets and liver cancer stiffness, aiming identify novel therapeutic targets for patients. Single-cell sequencing datasets were leveraged cell types within characterize transcriptomic profiles CAFs. Prognostic analysis, utilizing Gene Expression Profiling Interactive Analysis (GEPIA) Cancer Genome Atlas (TCGA) datasets, assessed correlation stiffness-related genes patient outcomes. Pseudo-time analysis was applied trace developmental trajectories By calculating intercellular communication probabilities analyzing transcription factor activity, functions interactions different elucidated. Ontology (GO) used explore functional roles CAFs distinct Yes-associated protein 1 (YAP1) groups. Finally, cellular experiments animal further conducted validate hypotheses study. This identified subpopulations based on single-cell data analyzed transcriptional changes these subpopulations. Key findings include identification collagen type I alpha (COL1A1), III (COL3A1), lysyloxidase (LOX) as pivotal node during development. Moreover, expression inversely correlated with prognosis Notably, YAP1-positive subpopulation emerged primary contributor cancer. upregulates promotes tumor by activating signaling pathways such autophagy GTPase activity regulation. Cellular studies validated conclusion. uncovered subpopulation, particular, shown contribute upregulating relevant promoting through activation pathways.

Язык: Английский

Процитировано

0