Geographic and Viral Etiology Patterns of TERT Promoter and CTNNB1 Exon 3 Mutations in Hepatocellular Carcinoma: A Comprehensive Review DOI Open Access

Mariana Terra,

Thaís Barbosa Ferreira Sant’Anna, José J. Barros

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2889 - 2889

Опубликована: Март 22, 2025

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related mortality worldwide. Genetic alterations play critical role in hepatocarcinogenesis, with mutations telomerase reverse transcriptase promoter (TERTp) CTNNB1 exon 3 representing two frequently reported somatic events HCC. However, frequency distribution these vary across geographic regions viral etiologies, particularly hepatitis B virus (HBV) C (HCV). This study aimed to assess global etiological associations TERTp HCC through comprehensive literature review. Our analysis, encompassing over 4000 cases, revealed that were present 49.2% tumors, C228T being predominant variant (93.3% among mutated cases). A striking contrast was observed between etiologies: detected 31.6% HBV-related HCCs, compared 66.2% HCV-related cases. identified 23.1% showing similar association etiology, more cases (30.7%) than tumors (12.8%). Geographically, both exhibited comparable patterns, higher frequencies Europe, Japan, USA, while lower rates China, Taiwan, South Korea. findings underscore distinct molecular profiles according etiology origin, highlighting need for region- etiology-specific approaches prevention, diagnosis, targeted therapy.

Язык: Английский

Geographic and Viral Etiology Patterns of TERT Promoter and CTNNB1 Exon 3 Mutations in Hepatocellular Carcinoma: A Comprehensive Review DOI Open Access

Mariana Terra,

Thaís Barbosa Ferreira Sant’Anna, José J. Barros

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2889 - 2889

Опубликована: Март 22, 2025

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related mortality worldwide. Genetic alterations play critical role in hepatocarcinogenesis, with mutations telomerase reverse transcriptase promoter (TERTp) CTNNB1 exon 3 representing two frequently reported somatic events HCC. However, frequency distribution these vary across geographic regions viral etiologies, particularly hepatitis B virus (HBV) C (HCV). This study aimed to assess global etiological associations TERTp HCC through comprehensive literature review. Our analysis, encompassing over 4000 cases, revealed that were present 49.2% tumors, C228T being predominant variant (93.3% among mutated cases). A striking contrast was observed between etiologies: detected 31.6% HBV-related HCCs, compared 66.2% HCV-related cases. identified 23.1% showing similar association etiology, more cases (30.7%) than tumors (12.8%). Geographically, both exhibited comparable patterns, higher frequencies Europe, Japan, USA, while lower rates China, Taiwan, South Korea. findings underscore distinct molecular profiles according etiology origin, highlighting need for region- etiology-specific approaches prevention, diagnosis, targeted therapy.

Язык: Английский

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