Molecular mavericks: unveiling the matrix metalloproteinase gene’s role in ovarian cancer DOI Creative Commons

Devi Krishna Ratnakaran Bindhu,

Lavanya Murugan,

Sneha Grace Mathews

и другие.

Egyptian Journal of Medical Human Genetics, Год журнала: 2025, Номер 26(1)

Опубликована: Апрель 9, 2025

Abstract Ovarian cancer continues to rate among the most lethal gynecological tumors, in part due limited treatment options and late-stage discovery. A class of zinc-dependent endopeptidases known as matrix metalloproteinases (MMPs) has been identified a key player development spread ovarian cancer. MMPs are kind enzyme that may degrade different components extracellular matrix, facilitating invasion surrounding tissues by cells their subsequent metastasis. The main involved subject this review, particularly MMP-2 MMP-9. These enzymes play role new blood vessels, tumor invasion, epithelial-mesenchymal transition (EMT), all these critical for Growth factors like VEGF (vascular endothelial growth factor) many variables regulate activity MMPs, which create favorable environment growth. Genetic variants MMP genes especially important because they affect person’s risk developing how illness develops. This hereditary component emphasizes necessity individualized plans. Since both possible therapeutic targets prognostic markers, targeting them offers promising approach treatment. review highlights importance synthesizing recent findings highlighting improve patient outcomes allow more thorough grasp contribute open door novel strategies provide hope improved control difficult condition.

Язык: Английский

Molecular mavericks: unveiling the matrix metalloproteinase gene’s role in ovarian cancer DOI Creative Commons

Devi Krishna Ratnakaran Bindhu,

Lavanya Murugan,

Sneha Grace Mathews

и другие.

Egyptian Journal of Medical Human Genetics, Год журнала: 2025, Номер 26(1)

Опубликована: Апрель 9, 2025

Abstract Ovarian cancer continues to rate among the most lethal gynecological tumors, in part due limited treatment options and late-stage discovery. A class of zinc-dependent endopeptidases known as matrix metalloproteinases (MMPs) has been identified a key player development spread ovarian cancer. MMPs are kind enzyme that may degrade different components extracellular matrix, facilitating invasion surrounding tissues by cells their subsequent metastasis. The main involved subject this review, particularly MMP-2 MMP-9. These enzymes play role new blood vessels, tumor invasion, epithelial-mesenchymal transition (EMT), all these critical for Growth factors like VEGF (vascular endothelial growth factor) many variables regulate activity MMPs, which create favorable environment growth. Genetic variants MMP genes especially important because they affect person’s risk developing how illness develops. This hereditary component emphasizes necessity individualized plans. Since both possible therapeutic targets prognostic markers, targeting them offers promising approach treatment. review highlights importance synthesizing recent findings highlighting improve patient outcomes allow more thorough grasp contribute open door novel strategies provide hope improved control difficult condition.

Язык: Английский

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