Effect and safety of perioperative ketamine/esketamine administration on postoperative pain and depression after breast cancer surgery: a systematic review and meta-analysis DOI Creative Commons
Xinyi Sun, Chengwei Li, Lin Xu

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 28, 2025

Patients with breast cancer experience varying degrees of pain, depression, and anxiety after surgery, which affect their postoperative recovery. Although ketamine/esketamine exhibit potential for opioid-sparing controlling pain effects on depression remain unclear. This meta-analysis aimed to evaluate whether perioperative administration could reduce improve recovery, the incidence adverse events in patients surgery. PubMed, Embase, Web Science, Cochrane Library, Clinical Trials were searched from inception until June 2, 2024 randomized controlled trials English language effect undergoing The primary outcome was score, secondary outcomes quality events, extubation time. standardized mean difference 95% confidence interval (CI) calculated continuous outcomes, risk ratio CI binary variables. Seven studies involving 748 included this meta-analysis. No significant differences found scores at 2 h, 4 1 day, 3 days, 7 months Postoperative days surgery lower group. dizziness statistically observed 30 recovery time, or nausea, vomiting, nightmares. Perioperative did not significantly surgery; however, it may within a short period https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42024572414, identifier CRD42024572414.

Язык: Английский

Effect and safety of perioperative ketamine/esketamine administration on postoperative pain and depression after breast cancer surgery: a systematic review and meta-analysis DOI Creative Commons
Xinyi Sun, Chengwei Li, Lin Xu

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 28, 2025

Patients with breast cancer experience varying degrees of pain, depression, and anxiety after surgery, which affect their postoperative recovery. Although ketamine/esketamine exhibit potential for opioid-sparing controlling pain effects on depression remain unclear. This meta-analysis aimed to evaluate whether perioperative administration could reduce improve recovery, the incidence adverse events in patients surgery. PubMed, Embase, Web Science, Cochrane Library, Clinical Trials were searched from inception until June 2, 2024 randomized controlled trials English language effect undergoing The primary outcome was score, secondary outcomes quality events, extubation time. standardized mean difference 95% confidence interval (CI) calculated continuous outcomes, risk ratio CI binary variables. Seven studies involving 748 included this meta-analysis. No significant differences found scores at 2 h, 4 1 day, 3 days, 7 months Postoperative days surgery lower group. dizziness statistically observed 30 recovery time, or nausea, vomiting, nightmares. Perioperative did not significantly surgery; however, it may within a short period https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42024572414, identifier CRD42024572414.

Язык: Английский

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