Pharmacology & Therapeutics, Год журнала: 2023, Номер 253, С. 108576 - 108576
Опубликована: Дек. 7, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Сен. 22, 2022
RNA modifications have become hot topics recently. By influencing processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune abnormality in human diseases is also a research focus progressing rapidly these years. Studies demonstrated that participate the multiple biological processes cells, development, differentiation, activation, migration, polarization, thereby modulating responses are involved some related diseases. In this review, we present existing knowledge functions underlying mechanisms modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), N4-acetylcytosine (ac4C), pseudouridine (Ψ), uridylation, adenosine-to-inosine (A-to-I) editing, summarize their roles Via regulating can pathogenesis diseases, such cancers, infection, inflammatory autoimmune We further highlight challenges future directions based on knowledge. All all, review will provide helpful well novel ideas for researchers area.
Язык: Английский
Процитировано
210
Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101063 - 101063
Опубликована: Фев. 1, 2024
This study aims to explore the function and mechanism of G Protein-coupled receptor class C group 5 member A (GPRC5A) in docetaxel-resistance liver metastasis breast cancer.
Язык: Английский
Процитировано
88
Molecular Cancer, Год журнала: 2022, Номер 21(1)
Опубликована: Июль 18, 2022
Abstract The resistance of tumor cells to therapy severely impairs the efficacy treatment, leading recurrence and metastasis various cancers. Clarifying underlying mechanisms therapeutic may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is most prevalent RNA modification in eukaryotes, involved regulation splicing, translation, transport, degradation, stability processing, thus affecting several physiological processes progression. As a novel type multifunctional non-coding RNAs (ncRNAs), circular (circRNAs) have been demonstrated play vital roles anticancer therapy. Currently, accumulating studies revealed mutual m6A circRNAs, their interaction can further influence sensitivity treatment. In this review, we mainly summarized recent advances circRNAs modulation resistance, as well interplay potential mechanisms, providing promising insights future directions reversal cancer.
Язык: Английский
Процитировано
87
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Июнь 30, 2023
Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible posttranscriptional RNA that mediated by m6A regulators or methylation regulators, i.e., methyltransferases ("writers"), demethylases ("erasers"), m6A-binding proteins ("readers"). Aberrant associated with cancer occurrence, development, progression, prognosis. Numerous studies have established aberrant function as either tumor suppressors oncogenes in multiple types. However, the functions mechanisms of remain largely elusive should be explored. Emerging suggest can modulated epigenetic modifications, namely, ubiquitination, SUMOylation, acetylation, methylation, phosphorylation, O-GlcNAcylation, ISGylation, lactylation via noncoding action, cancer. This review summarizes current roles The for modification genesis segregated. will improve understanding regulatory regulators.
Язык: Английский
Процитировано
86
Trends in Molecular Medicine, Год журнала: 2023, Номер 29(6), С. 454 - 467
Опубликована: Апрель 15, 2023
Язык: Английский
Процитировано
64
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Март 1, 2023
Abstract N6-methyladenosine (m 6 A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m A writers, erasers, and readers, modulation involved myriad physiological pathological processes. Extensive studies have demonstrated diverse tumours, with effects on tumorigenesis, metastasis, resistance. Recent evidence has revealed an emerging role of tumour immunoregulation, divergent patterns been microenvironment. To depict regulatory immune microenvironment (TIME) its effect evasion, this review focuses TIME, which characterized hypoxia, metabolic reprogramming, acidity, immunosuppression, outlines A-regulated TIME evasion under stimuli. Furthermore, anti-tumour cells are summarized.
Язык: Английский
Процитировано
58
Clinical and Translational Medicine, Год журнала: 2023, Номер 13(10)
Опубликована: Окт. 1, 2023
Background N6-methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed demethylases and recognised m6A-binding proteins. This significantly influences carious facets of RNA metabolism plays a pivotal role cellular physiological processes. Main body Pre-mRNA alternative splicing, process that generates multiple splice isoforms from multi-exon genes, contributes to protein diversity mammals. Moreover, presence crosstalk between with modifications on pre-mRNAs exerting regulatory control, has been established. The modulates splicing patterns recruiting specific RNA-binding proteins (RBPs) regulate or directly influencing interaction RBPs their target RNAs. Conversely, can impact deposition recognition mRNAs. integration expanded scope therapeutic strategies for cancer treatment, while offers novel insights into mechanistic methylation initiation progression. Conclusion review aims highlight biological functions machinery its implications tumourigenesis. Furthermore, we discuss clinical relevance understanding m6A-dependent tumour therapies.
Язык: Английский
Процитировано
49
Advanced Science, Год журнала: 2024, Номер 11(28)
Опубликована: Май 20, 2024
The RNA modification, 5-methylcytosine (m
Язык: Английский
Процитировано
32
Advanced Science, Год журнала: 2024, Номер 11(13)
Опубликована: Янв. 21, 2024
Abstract N6‐methyladenosine (m 6 A) modification orchestrates cancer formation and progression by affecting the tumor microenvironment (TME). For hepatocellular carcinoma (HCC), immune evasion angiogenesis are characteristic features of its TME. The role YTH RNA binding protein 2 (YTHDF2), as an m A reader, in regulating HCC TME not fully understood. Herein, it is discovered that trimethylated histone H3 lysine 4 27 acetylation promoter region YTHDF2 enhanced expression HCC, upregulated predicted a worse prognosis. Animal experiments demonstrated Ythdf2 depletion inhibited spontaneous formation, while overexpression promoted xenografted progression. Mechanistically, recognized 5′‐untranslational ETS variant transcription factor 5 (ETV5) mRNA recruited eukaryotic translation initiation 3 subunit B to facilitate translation. Elevated ETV5 induced programmed death ligand‐1 vascular endothelial growth A, thereby promoting angiogenesis. Targeting via small interference RNA‐containing aptamer/liposomes successfully both Together, this findings reveal potential application prognosis targeted treatment.
Язык: Английский
Процитировано
27
Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(3), С. 600 - 615
Опубликована: Март 1, 2024
Abstract 5-Methylcytosine (m 5 C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but crosstalk between m C and biomolecule condensation, as well transcription factor-mediated transcriptional regulation, in ovarian cancer, poorly understood. In this study, we revealed methyltransferase NSUN2 facilitates mRNA forms positive feedback regulatory loop with factor E2F1 cancer. Specifically, promotes of increases its stability, binds to promoter, subsequently reciprocally activating transcription. The binding protein YBX1 functions reader involved NSUN2-mediated regulation. phase separation, which upregulates expression. are amplified upregulated, higher predicts worse prognosis for cancer patients. Moreover, transcriptionally regulates oncogenes MYBL2 RAD54L, driving progression. Thus, our study delineates NSUN2-E2F1-NSUN2 regulated by manner dependent on previously unidentified pathway could be promising target treatment.
Язык: Английский
Процитировано
22