Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217544 - 217544

Опубликована: Фев. 1, 2025

Язык: Английский

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Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 29, 2024

Cell death is a fundamental part of life for metazoans. To maintain the balance between cell proliferation and metabolism human bodies, certain number cells need to be removed regularly. Hence, mechanisms have been preserved during evolution multicellular organisms. Tumorigenesis closely related with exceptional inhibition death. Mutations or defects in death-related genes block elimination abnormal enhance resistance malignant chemotherapy. Therefore, investigation enables development drugs that directly induce tumor In guidelines updated by Death Nomenclature Committee (NCCD) 2018, was classified into 12 types according morphological, biochemical functional classification, including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, PARP-1 parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence mitotic catastrophe. The mechanistic relationships epigenetic controls cancer progression were previously unclear. this review, we will summarize pathways corresponding regulations. Also, explore extensive interactions these discuss epigenetics which bring benefits therapy.

Язык: Английский

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Orbital ameloblastoma: research and challenges of a rare benign tumor

Holistic Integrative Oncology, Год журнала: 2025, Номер 4(1)

Опубликована: Янв. 13, 2025

Abstract There are numerous types of orbital tumors, among which ameloblastoma is a rare metastatic benign tumor that often originates in the jaw and later metastasizes to orbit. The mystery it lies that, although classified as tumor, exhibits high recurrence malignant potential with invasiveness, posing serious threat ocular health quality life patients. prognosis relatively poor, but there still hope. With aggressive treatment close follow-up observation, patients may have possibility achieving longer survival period better life. global incidence 0.92 cases per million people year. According world literature reports, 32 maxillary bone metastasis orbit 4 mandibular more related research being reported, necessary comprehensively review etiology, clinical manifestations, diagnosis, treatment, ameloblastoma, order enhance ophthalmologists' understanding diagnostic skills this disease, ultimately improve patients'

Язык: Английский

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Integrative Analysis of Radiation-Induced Senescence-Associated Secretory Phenotype Factors in Kidney Cancer Progression

Genes, Год журнала: 2025, Номер 16(1), С. 85 - 85

Опубликована: Янв. 15, 2025

Background: Ionizing radiation (IR) is a well-known inducer of cellular senescence and the senescence-associated secretory phenotype (SASP). SASP factors play dual roles in cancer, either promoting or inhibiting its development. This study investigates IR-induced specifically secreted by renal cortical epithelial (RCE) cells their role cell carcinoma (RCC) progression. Methods: Proteomic data from Atlas were analyzed to identify unique RCE cells, with subsequent evaluations performed at both gene protein levels. Thirty-seven proteins identified as exclusively upregulated senescent cells. Gene expression analysis these RCE-specific was conducted using Expression database Normal Tumor tissues (GENT2) The Cancer Genome (TCGA). To assess prognostic relevance RCC, corresponding further Human Protein (HPA), emphasizing relationship between factor RCC Results: ALDH18A1 ASPH emerged key significant upregulation levels (Log2 ratio > 1.15, p < 0.05). These are implicated pro-cancer activities strongly associated poor outcomes RCC. Their critical progression underscore potential promising therapeutic targets for prevention treatment disease. Conclusions: provides novel insights into carcinogenesis, marking first identification specific tumor suggests that hold promise early biomarkers disease treatment.

Язык: Английский

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The role of SASP in ischemic stroke: a deep dive into cellular mechanisms

Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Янв. 27, 2025

Background The escalating incidence of ischemic stroke (IS) exerts a heavy toll on global health. Aging, prominent risk factor, implicates the senescence-associated secretory phenotype (SASP) in IS pathogenesis. We postulated that alterations SASP-related factor expression during correlate with remodeling intercellular interaction networks and disease advancement. present study endeavored to preliminarily dissect SASP-IS nexus via combined bulk single-cell transcriptome analysis. Methods Aggregated profiles from human peripheral blood chips MCAO mouse sequencing data, followed by SASP gene Executed protein network enrichment assays. Investigated immune infiltration patients, managed quality control annotation cherry-picked central cells based scores, unearthed essential genes analysis, conducted pseudo-time communication studies, prognosticated drugs for hub genes. Finally, authenticated core serum Sham rats using real-time fluorescent polymerase chain reaction (RT-qPCR). Results Fourteen were discerned. Seven cell types annotated data. Basophils exhibited highest Lcp1 upregulated Ccl3 downregulated basophils group. Enrichment analysis divulged significant association apoptosis pathway responses. is pivotal basophil-neutrophil crosstalk. Additionally, we forecasted nagrestipen’s regulatory function Ccl3. RT-qPCR demonstrated marked elevation mRNA pronounced reduction group relative Conclusion its linchpin microenvironment. might potentially modulate progression influencing SASP, proffering novel prospects clinical diagnosis treatment.

Язык: Английский

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Oversecretion of CCL3 by Irradiation-Induced Senescent Osteocytes Mediates Bone Homeostasis Imbalance

Cells, Год журнала: 2025, Номер 14(4), С. 249 - 249

Опубликована: Фев. 10, 2025

Various stressors such as ionizing radiation (IR), chemotherapeutic agents, oxidative stress, and inflammatory responses can trigger the stress-induced premature senescence (SIPS) of cells in bone microenvironment, including osteocytes. However, little is known about mechanisms underlying senescent cellular regulation differentiation potential homeostasis. Here, we report a secretory change osteocytes activated by IR, its subsequent impact on osteogenic osteoclastic differentiation, cascade response. It was observed that exhibited altered biological function, persistent incomplete DNA damage repair, characteristic phenotypes after exposure to IR vitro. Meanwhile, concomitant increase CC chemokine ligand 3 (CCL3), key component senescence-associated phenotype (SASP), IR-induced osteocytes, which could further downregulate enhance cell supernatant co-culture experiments. Notably, enhancement PI3K/Akt/NF-κB signaling pathway appears be an essential driver imbalance between potentials. Taken together, these data suggest novel role CCL3 homeostatic through SASP secretion, mediated pathway.

Язык: Английский

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A Novel Prognostic Signature of Mitophagy-Related E3 Ubiquitin Ligases in Breast Cancer

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1551 - 1551

Опубликована: Фев. 12, 2025

Mitophagy plays a critical role in maintaining mitochondrial quality and cellular homeostasis. But the specific contribution of mitophagy-related E3 ubiquitin ligases to prognoses remains largely unexplored. In this study, we identified novel ligase prognostic signature using least absolute shrinkage selector operator (LASSO) multivariate Cox regression analyses breast cancer. Based on median risk scores, patients were divided into high-risk low-risk groups. Functional enrichment conducted explore biological differences between two Immune infiltration, drug sensitivity, mitochondrial-related phenotypes also analyzed evaluate clinical implications model. A four-gene (ARIH1, SIAH2, UBR5, WWP2) was identified, Kaplan-Meier analysis demonstrated that group had significantly worse overall survival (OS). The exhibited disrupted metabolism immune dysregulation with upregulated checkpoint molecules. Additionally, higher sensitivity several drugs targeting Akt/PI3K/mTORC1 signaling axis. Accompanying metabolic dysregulation, mtDNA stress elevated, contributing activation senescence-associated secretory phenotype (SASP) group. conclusion, provides robust tool for stratification offers insights interplay mitophagy, modulation, therapeutic responses

Язык: Английский

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Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)

Aging, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Aging | doi:10.18632/aging.206224. Sudipta Bar, Tyler A.U. Hilsabeck, Blaine Pattavina, José Alberto López-Domínguez, Nathan Basisty, Joanna Bons, Mark Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi, Amit Sharma

Язык: Английский

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A prognostic model based on autophagy-and senescence-related genes for gastric cancer: implications for immunotherapy and personalized treatment

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 20, 2025

Background The process of human aging is accompanied by an increased susceptibility to various cancers, including gastric cancer. This heightened linked the shared molecular characteristics between and tumorigenesis. Autophagy considered a critical mediator connecting cancer, exerting dynamic regulatory effect in conjunction with cellular senescence during tumor progression. In this study, combined analysis autophagy- senescence-related genes was employed comprehensively capture heterogeneity. Methods gene expression profiles clinical data for GC samples were acquired from TCGA GEO databases. Differentially expressed (DEASRGs) identified normal tissues. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses carried out provide insights into biological significance. A prognostic signature established using univariate Cox LASSO regression analyses. Furthermore, consensus clustering nomograms survival prediction. TME drug sensitivity conducted compare differences groups. To predict immunotherapy efficacy, correlations risk score immune checkpoints, MSI, TMB, TIDE scores investigated. Results fourteen-gene superior accuracy constructed. patients stratified three distinct clusters, each exhibiting significant variations their prognosis microenvironments. Drug revealed that low-risk group demonstrated greater responsiveness several commonly used chemotherapeutic agents oxaliplatin. further indicated high-risk exhibited cell infiltration, upregulated ICs, higher stromal score, suggesting capacity evasion. contrast, characterized proportion microsatellite instability-high (MSI-H) cases, elevated indicating likelihood benefiting immunotherapy. addition, Single-cell sequencing TXNIP epithelial cells. Cellular experiments preliminarily verified could promote proliferation migration cancer Conclusion study presents robust predictive model genes, demonstrating its ability effectiveness, guide personalized treatment.

Язык: Английский

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Lactylation: A Novel Epigenetic Regulator of Cellular Senescence

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It also an important mechanism by which body responds to damage potential carcinogenesis. However, excessive or abnormal cellular can lead tissue functional degradation occurrence diseases. In recent years, role epigenetic modifications in has received extensive attention. Lactylation, novel post-translational modification derived from lactate, recently gained significant attention as key factor metabolism regulation, gradually demonstrating its importance regulation senescence. This review emphasizes bidirectional causal relationship between lactylation senescence, highlighting therapeutic target for aging-related

Язык: Английский

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