Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140523 - 140523

Опубликована: Фев. 1, 2025

Язык: Английский

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RMethyMD: an integrated platform for exploring RNA methylation in pan-cancer via a multiomics analysis

Cancer Letters, Год журнала: 2025, Номер 612, С. 217462 - 217462

Опубликована: Янв. 12, 2025

Язык: Английский

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The RNA Demethyltransferase FTO Regulates Ferroptosis in Major Depressive Disorder

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1075 - 1075

Опубликована: Янв. 26, 2025

Major depressive disorder (MDD) is a widespread and severe mental health condition characterized by persistent low mood loss of interest. Emerging evidence suggests that ferroptosis, an iron-dependent form cell death, epigenetic dysregulation contribute to the pathogenesis MDD. This study investigates role RNA demethylase FTO autophagy regulator BECN1 in ferroptosis their regulation active compound ginsenoside Rb1 (GRb1) as potential antidepressant strategy. Hippocampal tissues from postmortem MDD patient brains mice with chronic restraint stress (CRS)-induced depression were analyzed. Ferroptosis was evaluated analyzing levels markers such glutathione (GSH) malondialdehyde (MDA). GRb1 administered CRS model gavage explore its effects on ferroptosis-related pathways. The results showed expression reduced hippocampal patients mice, promoting via disruption antioxidant system. Moreover, treatment increased expression, modulated m6A methylation, restored balance, inhibited mice. These findings reveal novel mechanism highlight promising agent for treating through targeting

Язык: Английский

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Silver niobate/platinum piezoelectric heterojunction enhancing intra-tumoral infiltration of immune cells for transforming “cold tumor” into “hot tumor”

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137303 - 137303

Опубликована: Март 12, 2025

Язык: Английский

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Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 19, 2025

Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing suppressive immune response. On the other hand, also occurs due to its non-selective properties, which compromise anti-tumor immunity. To address these challenges, two-pronged is proposed, encompassing selectively triggered and blockade, aimed at eliciting systemic immunity alleviating immunosuppression. Herein, GSH-specific driven nanoplatform composed of uniform FeOOH nanospindles coated with tetrasulfide bond-bridged mesoporous organosilica (DMOS) shell, loaded inhibitor, glycyrrhizic acid (GA). This endowed high glutathione (GSH) depletion efficiency exhibits highly efficient Fe2+ ROS generation capacity, promotes accumulation LPO subsequently induces ferroptosis. Concurrently, inhibition release counteracts immunosuppressive effects within microenvironment. innovative effectively suppresses growth 4T1 tumors notably enhancing therapeutic outcomes checkpoint blockade across experimental data. The collective findings indicate potential reliable strategy for boosting ferroptosis-mediated favorable safety profiles.

Язык: Английский

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Identification of N6-methyladenosine-associated ferroptosis biomarkers in cervical cancer

Hereditas, Год журнала: 2025, Номер 162(1)

Опубликована: Апрель 7, 2025

Abstract Background Cervical cancer (CC) stands as a major contributor to female mortality. The pathogenesis of CC is linked with various factors. Our research aimed unravel the underlying mechanisms ferroptosis and m6A RNA methylation in through bioinformatics analysis. Methods Three datasets, including GSE9750, GSE63514, TCGA-CESC, were incorporated. m6A-related genes derived from published sources, while ferroptosis-related obtained FerrDb database. Differential expression correlation analyses performed identify differentially expressed (DE-MRFGs) CC. Subsequently, biomarkers further identified using machine learning techniques. Gene Set Enrichment Analysis (GSEA) Kaplan–Meier (KM) survival analysis also comprehend these biomarkers. Furthermore, competing endogenous RNAs (ceRNA) network involving was established. Finally, verified by real-time quantitative polymerase chain reaction (RT-qPCR). Results From DE-MRFGs, six genes, ALOX12 , EZH2 CA9 CDCA3 CDC25A HSPB1 selected. A nomogram constructed based on exhibited potential clinical diagnostic value for CC, good accuracy confirmed calibration curves. GSEA unveiled associations cell proliferation, spliceosome, base excision repair. KM demonstrated significant differences outcomes between high low expressions samples. ceRNA three biomarkers, such 29 miRNAs, 25 lncRNAs. In RT-qPCR verification, significantly higher samples, control Conclusion Six namely m6A-regulated These findings offer valuable insights into disease hold promise advancing treatment prognosis.

Язык: Английский

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Correction: RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 8, 2024

Язык: Английский

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