Biotechnology and Bioengineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
ABSTRACT
Chondrosarcomas
(CHS)
constitute
approximately
20%
of
all
primary
malignant
bone
tumors,
characterized
by
a
slow
growth
rate
with
initial
manifestation
few
signs
and
symptoms.
These
cartilaginous
neoplasms,
particularly
those
dedifferentiated
histological
subtypes,
pose
significant
therapeutic
challenges,
as
they
exhibit
high
resistance
to
both
radiation
chemotherapy.
Ranging
from
relatively
benign,
low‐grade
tumors
(grade
I)
aggressive
high‐grade
the
potential
for
lung
metastases
grim
prognosis,
there
is
critical
need
innovative
diagnostic
approaches,
patients
more
forms.
Herein,
small
extracellular
vesicles
(sEVs)
derived
mesenchymal
stem
cells
are
presented
an
efficient
nanodelivery
tool
enhance
drug
penetration
in
vitro
3D
model
CHS.
Employing
high‐pressure
homogenization
(HPH),
we
achieved
unprecedented
encapsulation
efficiency
doxorubicin
(DXR)
sEVs
(MSC‐EVs).
Subsequently,
comparative
analysis
between
free
DXR
MSC‐EVs
encapsulated
(DXR‐MSC‐EVs)
was
conducted
assess
their
uptake
efficacy
model.
The
results
unveiled
higher
incidence
necrotic
pronounced
toxic
effect
DXR‐MSC‐EVs
compared
alone.
This
underscores
remarkable
ability
deliver
drugs
complex
environments,
highlighting
application
treatment
Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
Bone
metastasis
often
develops
in
advanced
malignancies.
Lipid
metabolic
dysregulation
might
play
pivotal
role
cancer
progression
and
subsequent
deterioration
of
bone
health
at
metastatic
condition.
In-depth
understanding
lipid
reprogramming
metastasized
cells
other
stromal
including
marrow
adipocyte
(BMA)
is
an
urgent
need
to
develop
effective
therapy.
This
paper
emphasizes
providing
overview
multifaceted
dysregulated
lipids
BMA
association
with
by
utilizing
search
terms
metabolism,
PubMed.
study
extends
address
mechanism
linked
metabolism
various
crucial
genes
(e.g.
CSF-1,
RANKL,
NFkB
NFATc1)
involved
metastasis.
review
examines
therapeutic
strategies
targeting
offer
potential
avenues
disrupt
lipid-driven
On
condition,
molecules
especially
not
only
favors
but
also
potentiate
within
cells.
Distinct
lipid-metabolism
associated
may
act
as
biomarker,
these
challenging
task
for
specific
treatment.
Curbing
function
resorption
controlling
drugs
statins,
omega-3
FA
metformin)
provide
additional
support
curtail
lipid-associated
Delving
into
cancer
dormancy
has
been
an
inherent
task
that
may
drive
the
lethal
recurrence
of
after
primary
tumor
relief.
Cells
in
quiescence
can
survive
for
a
short
or
long
term
silence,
undergo
genetic
epigenetic
changes,
and
initiate
relapse
through
certain
contextual
cues.
The
state
be
induced
by
multiple
conditions
including
drug
treatment,
turn,
undergoes
life
cycle
generally
occurs
dissemination,
invasion,
intravasation,
circulation,
immune
evasion,
extravasation,
colonization.
Throughout
this
cascade,
cellular
machinery
governs
fate
individual
cells,
largely
affected
gene
regulation.
Despite
its
significance,
precise
view
is
yet
hampered.
Revolutionizing
advanced
single
cell
read
sequencing
analysis
methodologies
artificial
intelligence,
most
recent
stage
research
tool
progress,
expected
to
provide
holistic
diverse
aspects
dormancy.
Bone
tumors
with
high
mortality
and
disability
have
become
a
major
clinical
challenge.
Herewith,
it
is
necessary
to
design
materials
for
bone
tumor
therapy
repair.
In
this
work,
Fe-doped
polypyrrole
(Fe-Ppy)
CaO2
are
constructed
on
sulfonated
polyetheretherketone
(SP)
form
multistage-responsive
coating.
The
coating
achieves
long-lasting
antitumor
through
chemodynamic
(CDT),
photothermal
(PTT),
combined
immunotherapy.
Fe-Ppy
acts
as
an
electron
pump
replenish
Fe2+
oxidizing
-NH-
-N+-,
which
lasts
the
Fenton
reaction
persistently
produces
reactive
oxygen
species
(ROS)
in
microenvironment
(TME).
selectively
provides
exogenous
H2O2
response
TME
boost
cycle.
Stronger
near-infrared
light
absorption
due
Fe
doping
more
photon
traps
caused
by
porous
structure-induced
scattering
refraction
diminishment
improve
conversion
of
modified
SP.
Furthermore,
ROS
effective
enhance
M1
activation
secrete
TNF-α
IFN
kill
cells.
After
therapy,
Fe-Ppy@CaO2-modified
SP
could
adaptively
switch
macrophage
M2
promote
osteogenesis
abolishment
NIR
stimulation.
summary,
ROS,
enhanced
conversion,
immunomodulation
potential
candidate
tissue
