[TIM3+CD8+ T Cell Expression and Clinical Significance in the Central and Non-central Tumor Microenvironment of Non-small Cell Lung Cancer]. DOI

Jia-juan Wu,

Shiying Guo,

Lei-lei Lv

и другие.

PubMed, Год журнала: 2024, Номер 27(12), С. 903 - 910

Опубликована: Дек. 20, 2024

One of the most important treatment modalities for non-small cell lung cancer (NSCLC) is immune checkpoint inhibitor. Nevertheless, a small percentage patients do not respond well to these therapies, highlighting significance identifying CD8+ T subsets immunotherapy and creating trustworthy biomarkers. The purpose this study assess potential utility TIM3+CD8+ cells as new biomarkers by examining their expressions in various areas NSCLC tumor microenvironment. Based on biopsy techniques, tissue samples were obtained from with categorized into central non-central regions. Using flow cytometry, infiltration surface expression programmed death 1 (PD-1) examined, correlations effectiveness assessed. region tissues had considerably larger lymphocytes compared (P<0.0001). This pattern was found both subgroups diameters ≥3 cm or <3 (P<0.01). In comparison TIM3-CD8+ cells, showed higher levels PD-1 (P<0.001), more PD-1+TIM3+CD8+ invading Clinical responders lower non-responders, correlated better clinical outcomes (P<0.01), while no correlation identified (P>0.05). According reciever operating characteristic (ROC) curve analysis, an area under (AUC) 0.9375 predicting immunotherapy, which than that ligand (PD-L1) [tumor proportion score (TPS)]. microenvironment NSCLC, show regional distribution patterns. population may be biomarker immunotherapy.

Язык: Английский

High CXCL8 expression predicting poor prognosis in triple-negative breast cancer DOI Creative Commons

Sumin Tang,

Yuqing Zhang,

Liying Song

и другие.

Anti-Cancer Drugs, Год журнала: 2025, Номер 36(3), С. 246 - 252

Опубликована: Янв. 6, 2025

Triple-negative breast cancer (TNBC) is highly prone to early relapse and metastasis following standard treatment. CXCL8 a key factor in tumor invasion metastasis, but its role TNBC prognosis clinicopathological correlations remains poorly understood. This study investigated expression clinical significance develop prognostic nomogram for guiding intensive treatment follow-up strategies. Public datasets from the gene omnibus public platform were analyzed assess expression. Additionally, paraffin-embedded specimens collected our hospital examined using immunohistochemistry explore relationship between features. Survival analysis was performed evaluate whether serves as an unfavorable biomarker patients. Univariate Cox regression conducted identify factors. Based on these findings, developed predict progression risk. significantly higher tissues than adjacent normal ( P < 0.05). Among 122 patients, 46 CXCL8-positive 76 CXCL8-negative. associated with N stage Progression-free survival (PFS) markedly shorter group compared CXCL8-negative 0.001). identified N1-3, M1, positivity significant risk factors disease progression. A incorporating variables (N, M, CXCL8) constructed PFS. Time-dependent receiver operating characteristic curve at 12-, 36-, 48-month demonstrated strong predictive performance, area under values of 0.857, 0.839, 0.795, respectively. expressed promotes lymphatic serving factor. The offers valuable tool personalized strategies

Язык: Английский

Процитировано

0
Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload DOI
Linwei Li,

Zihan Xing,

Jinyu Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 299, С. 140116 - 140116

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0
Regulation of Cell Death: Therapeutic Strategies for Cancer Treatment DOI Creative Commons
Attalla F. El‐kott, Fahmy G. Elsaid, Heba I. Ghamry

и другие.

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

This chapter explores how to regulate programmed cell death and its relevance in cancer therapy. It points the need of investigate mechanisms death, like apoptosis, necroptosis, and, more recently, exposed ferroptosis, while creating approaches for treatment malignant diseases. In spite progress field targeted therapies, is still a main cause due incapability cells undergo apoptosis. The highlights significance adopting complex that encompass multiple types occurring within both tumor microenvironment. Of note are functions oncogenes suppressor genes regulation cellular processes, specific role apoptosis formation process, possibility increase neoplastic cells. There metastasis critical such as TP53 gene, along with presence an over expression anti-apoptotic proteins. Examples this would include Bcl-2 IAPs, which protect against stimuli required death. immunotherapy combination therapies described emerging strategies enhance efficacy treatments. document also deals problem resistance induction necessity further clinical studies new therapeutic agents practice. summary, it diversity biology paradigm shift achieve

Язык: Английский

Процитировано

0
Bacterial-Mediated In Situ Engineering of Tumour-Associated Macrophages for Cancer Immunotherapy DOI Open Access

Gabriela Christina Kuhl,

Mark Tangney

Cancers, Год журнала: 2025, Номер 17(5), С. 723 - 723

Опубликована: Фев. 20, 2025

Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.

Язык: Английский

Процитировано

0
Enhanced antitumor efficacy of bispecific antibody blocking PD-L1 and LAG-3 with doxorubicin: mechanism and safety evaluation DOI

Chenxing Zhang,

Jiaxin Liu,

Tiejun Gu

и другие.

Breast Cancer Research and Treatment, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
A Self‐Priming Pyroptosis‐Inducing Agent for Activating Anticancer Immunity DOI Open Access
Yanjie Li, Hanxin Feng, Yang Huang

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract Pyroptosis, a form of programmed cell death mediated by the gasdermin family, has emerged as promising strategy for inducing anti‐tumor immunity. However, efficiently pyroptosis in tumor cells remains significant challenge due to limited activation key mediators like caspases tissues. Herein, self‐priming pyroptosis‐inducing agent (MnNZ@OMV) is developed integrating outer membrane vesicles (OMVs) with manganese dioxide nanozymes (MnNZ) trigger cells. OMVs, derived from Escherichia coli , are coated onto spiny MnNZ prepare MnNZ@OMV. Once internalized cells, MnNZ@OMV responds elevated intracellular glutathione (GSH) levels, releasing Mn 2 ⁺ and OMV components. This leads GSH depletion ⁺‐catalyzed reactive oxygen species generation, which triggers NF‐κB translocation prime caspase‐11 expression. Subsequently, lipopolysaccharides OMVs activate caspase‐11, resulting GSDMD cleavage induction. significantly induces vivo, promoting dendritic maturation CD8⁺ T activation, leading robust effects. Collectively, this study presents novel approach through noncanonical caspase‐11/GSDMD pathway, offering avenue future cancer immunotherapy.

Язык: Английский

Процитировано

0
Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities DOI Creative Commons
Rui Miao,

Xueying Wang,

Jingyv Zhang

и другие.

Biomarker Research, Год журнала: 2025, Номер 13(1)

Опубликована: Апрель 9, 2025

Abstract Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and cell lysis phase, latter which is irreversible. Besides immune cells, pyroptosis has also observed in cancer exhibit distinct mechanisms compared to canonical Although chronic fuels tumor growth, intense death cells enhances anticancer immunity by promoting killer lymphocytes infiltration. Triggering emerging as promising strategy for treatment. In this review, we introduce its role antitumor immunity, discuss translation these insights into therapies, highlight current challenges opportunities investigation

Язык: Английский

Процитировано

0
Cytokine-mediated regulation of immune cell metabolic pathways in the tumor microenvironment DOI

Alireza Soleimani Mamalo,

Mohammad Reza Pashaei, Mohammad Valilo

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

Язык: Английский

Процитировано

0
Isoform switch of CD47 provokes macrophage-mediated pyroptosis in ovarian cancer DOI Creative Commons
Zixiang Wang, Lei Yang, Siyuan Yang

и другие.

Опубликована: Апрель 18, 2025

Abstract Cancer cells expressing CD47 escape macrophage phagocytosis by binding to the SIRPα ligand expressed on macrophages. targeted therapy offers a promising approach cancer treatment. Here we report that two major isoforms of differ in ovarian and normal tissues. The truncated isoform lacking exon 9 10 (CD47-S) was exclusively tissues, whereas full-length (CD47-L) predominantly Interestingly, CD47-S unable locate at cell surface bind with as CD47-L did, thereby inactivated “don’t-eat-me” signal. Mechanistic investigations revealed splicing factor HNRNPA1 promoted switch from through skipping. We further developed antisense oligonucleotides (ASOs) effectively switched . Importantly, ASOs treatment evoked macrophage-mediated antitumor immune response, triggered pyroptosis cells. Moreover, CD47-targeting significantly reduced tumor growth patient-derived xenograft. Together, ASO-mediated has emerged strategy improve responses against tumors.

Язык: Английский

Процитировано

0
Hyaluronic acid-modified doxorubicin-covalent organic framework nanoparticles triggered pyroptosis in combinations with immune checkpoint blockade for the treatment of breast cancer DOI

Shengsheng Zhao,

Binglong Bai,

Bingzi Zhu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143265 - 143265

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0