Galangin Alleviates Alcohol-Provoked Liver Injury Associated with Gut Microbiota Disorder and Intestinal Barrier Dysfunction in Mice

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Prolonged and excessive intake of alcohol results in the onset alcoholic liver disease, which is marked by oxidative stress, intestinal barrier dysfunction, disturbance microbiome. Galangin, a potent flavonoid from

Язык: Английский

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Role of Alcohol in Steatotic Liver Disease: Impact on Patients with Cardiometabolic Risk Factors

Digestive Diseases and Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The new definition of steatotic liver disease (SLD), as a broader concept, was step forward in the increasing recognition substantial overlap between alcohol and cardiometabolic risk factors (CMRFs), continuum way. spectrum pathophysiological aspects, ranging from steatosis to fibrosis, has similarities MASLD ALD. Also, there is now considerable evidence that association metabolic dysfunction with increased consumption impacts on severe prognosis. MetALD class, recently proposed, shows clear differences prognosis when comparing ALD groups. However, room for improvement, such considering role previous intake, fluctuations over time, including binge drinking, refinement assessment, better understanding biomarkers. In summary, SLD no doubt significant but classification needs be dynamic adapting patients needing frequent reassessment. Furthermore, it brings opportunities research interaction CMRFs.

Язык: Английский

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Normative Modeling Reveals Age‐Atypical Cortical Thickness Differences Between Hepatic Steatosis and Fibrosis in Non‐Alcoholic Fatty Liver Disease

Brain and Behavior, Год журнала: 2025, Номер 15(4)

Опубликована: Апрель 1, 2025

ABSTRACT Objectives: To investigate individual variations and outliers in cortical thickness among non‐alcoholic fatty liver disease (NAFLD) patients, ranging from hepatic steatosis to fibrosis, using neuroanatomical normative modeling. Materials Methods: A cross‐sectional study with 2637 health check‐up subjects was conducted. Among NAFLD ( n = 556) fibrosis 57) were determined by index fibrosis‐4 score, respectively. Cortical 148 different brain regions assessed T1‐weighted MRI scans. publicly available model analyzed distributions data around 58,000 participants. The hierarchical Bayesian regression used estimate deviation for each region, taking age, sex, sites into account. On the basis of a normal adaptation set, Z ‐scores below −1.96 or above +1.96 per region classified as outliers. total outlier count (tOC) then calculated quantify regional heterogeneity. Mass univariate analysis conducted compare groups, spatial patterns heterogeneity qualitatively analyzed. Results: Patients had higher number positive (mean 6.3 ± 10.3) than 4.2 6.2, p 0.02). group difference testing revealed patients 6 areas thicker steatosis. Two groups showed shared temporal cortex. Conclusion: Distinct atrophy observed compared group, more frequent cortex both fibrosis. Hepatic slightly increased relative

Язык: Английский

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Lipid rafts: novel therapeutic targets for metabolic, neurodegenerative, oncological, and cardiovascular diseases

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 17, 2025

Lipid rafts are specialized microdomains within cellular membranes enriched with cholesterol and sphingolipids that play key roles in organization, signaling, homeostasis. This review highlights their involvement protein clustering, energy metabolism, oxidative stress responses, inflammation, autophagy, apoptosis. These findings clarify influence on trafficking, adhesion while interacting the extracellular matrix, cytoskeleton, ion channels, making them pivotal progression of various diseases. further addresses contributions to immune including autoimmune diseases, chronic cytokine storms. Additionally, role as entry points for pathogens has been demonstrated, raft-associated receptors being exploited by viruses bacteria increase infectivity evade defenses. Disruptions lipid raft dynamics linked signaling defects, which contribute metabolic, neurodegenerative, cardiovascular underscores potential therapeutic targets, discussing innovations such engineered transplantation. Advances analytical techniques mass spectrometry have expanded our understanding composition dynamics, opening new directions research. By consolidating current insights, we highlight need exploration molecular mechanisms.

Язык: Английский

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Extent to which weight loss contributes to improving metabolic dysfunction-associated and metabolic and alcohol related/associated steatotic liver disease: a study on Japanese participants undergoing health checkups

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 8, 2024

Introduction The incidence of steatotic liver disease has increased in recent years. Thus, is a major public health issue Japan. This study investigated the association between weight reduction and remission metabolic dysfunction-associated (MASLD)/Metabolic alcohol related/associated (MetALD) Japanese individuals undergoing checkups. Methods retrospective observational included 8,707 patients with MASLD/MetALD who underwent checkups from May 2015 to March 2023. participants were monitored for its at their subsequent visit. MASLD was diagnosed on abdominal ultrasonography based presence least one five abnormalities. impact body mass index (BMI) assessed via logistic regression analysis using receiver operating characteristic curves. Results Logistic revealed that loss significantly associated remission. Other factors including exercise habits reduced consumption significant predictors overall cohort male patients. optimal BMI cutoff values 0.9 kg/m 2 4.0% decrease cohort, 0.85 3.9% males, 1.2 4.5% females. In 23 , 0.75 2.7% reduction. Discussion Weight plays an important role both MetALD among individuals. That is, targeting specific effective. underscores importance targeted management strategies preventing managing population.

Язык: Английский

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In Vitro Nonalcoholic Fatty Liver Disease Model Elucidating the Effect of Immune Environment on Disease Progression and Alleviation

ACS Omega, Год журнала: 2024, Номер 9(23), С. 25094 - 25105

Опубликована: Май 27, 2024

Nonalcoholic fatty liver disease (NAFLD), which is a major cause of chronic disease, characterized by fat accumulation in the liver. Existing models struggle to assess medication effects on function context NAFLD's unique inflammatory environment. We address this developing 3D vitro NAFLD model using HepG2 and THP-1 cells (mimicking Kupffer cells) cocultured transwell hydrogel system. This mimics architecture allows for manipulation immune demonstrate that recapitulates key features: steatosis (induced acids), oxidative stress, inflammation, impaired embodying interrelationship between surrounding versatile offers valuable tool preclinical research incorporating disease-relevant

Язык: Английский

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Rice Protein Peptides Alleviate Alcoholic Liver Disease via the PPARγ Signaling Pathway: Through Liver Metabolomics and Gut Microbiota Analysis

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(43), С. 23790 - 23803

Опубликована: Окт. 15, 2024

Alcoholic liver disease (ALD) is the predominant type of worldwide, resulting in significant mortality and a high burden. ALD damages multiple organs, including liver, gut, brain, causing inflammation, oxidative stress, fat deposition. In this study, we investigated effects rice protein peptides (RPP) on mice with primary focus gut microbiota metabolites. The results showed that administration RPP significantly alleviated symptoms adiposity, inflammation. KEGG pathway shows downregulates metabolite capric acid metabolism fatty biosynthesis compared MOD group. Mechanistically, downregulated PPARγ signaling suppressed expression genes (FASN, ACC1, ACSL1, ACSL3). Furthermore, two active (YLPTKQ PKLPR) potential therapeutic functions for were screened by Caco-2 cell modeling molecular docking techniques. addition, treatment alleviates dysbiosis reversing F/B ratio, increasing relative abundance Alloprevotella Alistipes, upregulating level short-chain acids. conclusion, steatosis through YLPTKQ PKLPR regulates microbiota.

Язык: Английский

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Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury

Expert Opinion on Therapeutic Targets, Год журнала: 2024, Номер 28(7), С. 545 - 573

Опубликована: Июнь 15, 2024

Chronic liver disease (CLD) is a complex associated with profound dysfunction. Despite an incredible burden, the first and only pharmacotherapy for metabolic-associated steatohepatitis was approved in March of this year, indicating gap translation preclinical studies. There body work on application phosphodiesterase 4 inhibitors CLD, none these molecules have been successfully translated into clinical use.

Язык: Английский

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miRNAs in patients with alcoholic liver disease: a systematic review and meta-analysis

Expert Review of Gastroenterology & Hepatology, Год журнала: 2024, Номер 18(6), С. 283 - 292

Опубликована: Июнь 2, 2024

Introduction Alcoholic liver disease (ALD) encompasses a spectrum of conditions, including steatosis, alcoholic hepatitis (AH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). microRNAs (miRNAs) have garnered significant interest as potential biomarkers for ALD.

Язык: Английский

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Metabolic Profiling and Early Diagnosis of Alcoholic Fatty Liver Disease Using Support Vector Machine Model

Advanced Gut & Microbiome Research, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Alcoholic fatty liver disease (AFLD) is one of the most common pathological changes associated with alcoholic disease. This study aimed at investigating specific metabolic occurring in AFLD and to develop a diagnostic method based on blood metabolomics AFLD. Twenty‐four rats were randomly divided into an group control group. The model was established by administering 40% alcohol verified pathologic examination. Metabolic investigated GC‐MS, both hepatic function ability assessed. Using data, developed support vector machine (SVM). validated using cross‐validation techniques achieved classification accuracy 100%. Additionally, there statistically significant differences metabolic, function, pharmacokinetic between two groups. level urea, hydroxysuccinic acid, 2‐propenoic total cholesterol, high‐density lipoprotein cholesterol increased, area under concentration‐time curve (AUC) (0 − t ), AUC ∞), C max phenacetin shorten ( p < 0.05). SVM data In conclusion, heightened early stage AFLD, leading accelerated metabolism urea acid. can be used detect data.

Язык: Английский

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