Plasma Lipidomics and Proteomics Analyses Pre- and Post-5000 m Race in Yili Horses
Animals,
Год журнала:
2025,
Номер
15(7), С. 994 - 994
Опубликована: Март 30, 2025
The
impact
of
exercise
on
human
metabolism
has
been
extensively
studied,
yet
limited
research
exists
the
effects
high-intensity
racing
equine
metabolism.
aim
this
study
was
to
screen
effect
a
5000
m
race
lipids
and
proteins
in
plasma
Yili
horses
for
breeding
racehorses.
Blood
samples
were
collected
from
top
three
finishers,
lipidomics
proteomics
analyses
performed.
Lipidomic
analysis
identified
10
differential
lipids.
Compared
pre-race
levels,
phosphatidylethanolamine
(18:0/16:0)
(PE
(18:0/16:0))
phosphatidylcholine
(18:0/18:2)
(PC
(18:0/18:2))
significantly
upregulated,
while
triglyceride
(26:4/29:4)
(TG
(26:4/29:4))
(46:14CHO)
(46:14CHO))
notably
downregulated.
These
primarily
associated
with
regulation
lipolysis
adipocytes
glycerolipid
pathways.
Proteomic
revealed
79
differentially
expressed
proteins.
Post-race,
proteasome
subunits
(alpha
type_2,
alpha
type_5
isoform
X1,
type_6,
beta
type_2),
carboxypeptidase
E,
S-phase
kinase-associated
protein
1
showed
significant
downregulation.
involved
cellular
catabolic
process
(Gene
Ontology
term)
pathways
related
type
I
diabetes
mellitus
(Kyoto
Encyclopedia
Genes
Genomes
terms).
Correlation
indicated
positive
correlation
between
type_2
type_2)
PC
(18:0/18:2),
negative
found
(46:14CHO).
Conversely,
1,
along
X1
type_6),
exhibited
PE
TG
(26:4/29:4).
In
conclusion,
may
sustain
energy
balance
physiological
equilibrium
during
by
suppressing
degradation
optimizing
lipid
substances
could
serve
as
key
biomarkers
assessing
load
horses.
Язык: Английский
Narrative Review of High-Intensity Interval Training: Positive Impacts on Cardiovascular Health and Disease Prevention
Journal of Cardiovascular Development and Disease,
Год журнала:
2025,
Номер
12(4), С. 158 - 158
Опубликована: Апрель 17, 2025
Background:
High-intensity
interval
training
(HIIT)
has
gained
recognition
for
its
positive
impacts
on
cardiovascular
(CV)
health,
metabolic
outcomes,
mental
and
quality
of
life
(QoL).
This
narrative
review
aims
to
comprehensively
evaluate
the
efficacy
HIIT
in
enhancing
CV
health
preventing
disease
(CVD).
Methods:
A
comprehensive
search
PubMed
identified
257
articles,
which
39
studies
met
predefined
inclusion
exclusion
criteria
assessment.
Key
metrics
evaluated
included
blood
pressure,
vascular
function,
lipid
profiles,
body
composition,
CRF.
Results:
significantly
improved
evidenced
by
reductions
systolic
diastolic
pressure
enhanced
flow-mediated
dilation.
Improvements
cardiac
function
were
observed
through
increased
output
heart
rate
variability.
Additionally,
positively
influenced
decreasing
low-density
lipoprotein
triglycerides
while
increasing
high-density
lipoprotein.
Significant
fat
improvements
VO2peak
noted,
contributing
also
impacted
QoL,
reducing
anxiety
depressive
symptoms.
Importantly,
was
safely
effectively
applied
high-risk
populations—individuals
with
obesity,
syndrome,
CVD,
cancer
survivors—with
a
low
incidence
adverse
effects.
Conclusions:
highlights
as
an
effective
safe
exercise
modality
improving
indicators,
QoL.
Future
research
should
focus
developing
tailored
protocols
optimize
adherence
across
diverse
populations,
considering
variations
age,
sex,
status,
underlying
medical
conditions.
Язык: Английский