A review on micro and nanoengineering in Powder-Based pulmonary drug delivery

International Journal of Pharmaceutics, Год журнала: 2024, Номер 659, С. 124248 - 124248

Опубликована: Май 21, 2024

Pulmonary delivery of drugs has emerged as a promising approach for the treatment both lung and systemic diseases. Compared to other drug routes, inhalation offers numerous advantages including high targeting, fewer side effects, huge surface area absorption. However, deposition in lungs can be limited by defence mechanisms such mucociliary macrophages' clearance. Among devices, dry powder inhalers represent optimal choice due their stability, ease use, absence propellants. In last decades, several bottom-up techniques have over traditional milling produce inhalable powders. these techniques, most employed ones are spray drying, supercritical fluid technology, freeze-drying, thin film freezing. Inhalable powders constituted micronized attached coarse carrier (e.g., lactose) or embedded into micro- nanoparticle. Particulate-based formulations commonly composed polymeric nanoparticles, liposomes, solid lipid dendrimers, nanocrystals, extracellular vesicles, inorganic nanoparticles. Moreover, engineered large porous particles, swellable microparticles, nano-in-microparticles, effervescent nanoparticles been developed. Particle engineering also crucial role tuning physical-chemical properties carrier-based carrier-free This increase flowability, deposition, targeting customising particle features.

Язык: Английский

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A Universal Chemotactic Targeted Delivery Strategy for Inflammatory Diseases

Advanced Materials, Год журнала: 2022, Номер 34(47)

Опубликована: Сен. 19, 2022

Above 50% of deaths can be attributed to chronic inflammatory diseases; thus, the construction drug delivery systems based on effective interaction factors with chemotactic nanoparticles is meaningful. Herein, a zwitterion-based artificial nanomotor proposed for universal precise targeting strategy in vivo, where high level reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) sites are used as chemoattractant. Multidimensional static models, dynamic vivo models established evaluate performance. The results show that upregulated ROS iNOS induce chemotaxis nanomotors diseased tissues inflammation-related disease models. Further, mesoscale hydrodynamics simulations performed explain behavior nanomotors. Such expected improve efficiency may applicable variety diseases.

Язык: Английский

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Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals

Journal of Pharmaceutical Investigation, Год журнала: 2022, Номер 53(1), С. 35 - 57

Опубликована: Дек. 21, 2022

Язык: Английский

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An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management

Pharmaceuticals, Год журнала: 2023, Номер 16(4), С. 581 - 581

Опубликована: Апрель 12, 2023

Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, high pill burden, limited compliance, and strict administration schedules are all variables that contribute to development MDR XDR tuberculosis patients. The rise multidrug-resistant strains scarcity anti-TB medications pose threat TB control in future. As result, strong effective system required overcome technological limitations improve efficacy therapeutic medications, which still huge problem for pharmacological technology. Nanotechnology offers an interesting opportunity accurate identification mycobacterial improved medication treatment possibilities tuberculosis. Nano medicine emerging research field provides possibility efficient delivery using nanoparticles decrease drug dosages adverse effects boost patient compliance with therapy recovery. Due their fascinating characteristics, this strategy useful overcoming abnormalities associated traditional leads some optimization impact. It also decreases dosing frequency eliminates low compliance. To develop modern diagnosis techniques, upgraded possible prevention tuberculosis, nanoparticle-based tests have demonstrated considerable advances. literature search was conducted Scopus, PubMed, Google Scholar, Elsevier databases only. This article examines employing nanotechnology diagnosis, nanotechnology-based systems, successful elimination illnesses.

Язык: Английский

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Nanosized Drug Delivery Systems to Fight Tuberculosis

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 393 - 393

Опубликована: Янв. 24, 2023

Tuberculosis (TB) is currently the second deadliest infectious disease. Existing antitubercular therapies are long, complex, and have severe side effects that result in low patient compliance. In this context, nanosized drug delivery systems (DDSs) potential to optimize treatment’s efficiency while reducing its toxicity. Hundreds of publications illustrate growing interest field. review, main challenges related use nanocarriers fight TB overviewed. Relevant regarding DDSs for treatment classified according encapsulated drugs, from first-line second-line drugs. The physicochemical biological properties investigated formulations listed. could simultaneously (i) therapy’s antibacterial effects; (ii) reduce doses; (iii) posology; (iv) diminish toxicity; as a global result, (v) mitigate emergence resistant strains. Moreover, we highlight host-directed therapy using nanoparticles (NPs) recent promising trend. Although research on expanding, clinical applications yet be developed. Most studies only dedicated development new formulations, without vivo proof concept. near future, it expected NPs prepared by “green” scalable methods, with intrinsic capable co-encapsulating synergistic may find TB.

Язык: Английский

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A new hope? Possibilities of therapeutic IgA antibodies in the treatment of inflammatory lung diseases

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Март 27, 2023

Inflammatory lung diseases represent a persistent burden for patients and the global healthcare system. The combination of high morbidity, (partially) mortality limited innovations in last decades, have resulted great demand new therapeutics. Are therapeutic IgA antibodies possibly hope treatment inflammatory diseases? Current research increasingly unravels elementary functions as protector against infections modulator overwhelming inflammation. With focus on IgA, this review describes pathological alterations mucosal immunity how they contribute to chronic inflammation most common diseases. current knowledge circulation, particularly respiratory mucosa, are summarized. interplay between neutrophils seems be key control In addition, hurdles benefits antibodies, well currently known clinically used preparations described. data highlighted here, together with upcoming strategies aiming at circumventing pitfalls may pave way promising antibody class application

Язык: Английский

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Aerosol pulmonary immune engineering

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 199, С. 114831 - 114831

Опубликована: Апрель 24, 2023

Aerosolization of immunotherapies poses incredible potential for manipulating the local mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders, and accessing mucosal associated lymphoid tissue to redirect systemic adaptive memory responses. In this review, we breakdown key inhalable immunoengineering strategies chronic, genetic, infection-based inflammatory disorders, encompassing historic use immunomodulatory agents, transition biological inspired or derived treatments, novel approaches complexing these materials into drug delivery vehicles enhanced release outcomes. Alongside a brief description immune targets, fundamentals aerosol delivery, preclinical models response, survey recent advances inhaled immunotherapy platforms, ranging from small molecules biologics particulates cell therapies, as well prophylactic vaccines. each section, address formulation design constraints advantages platform in driving desirable modifications. Finally, prospects clinical translation outlook engineering are discussed.

Язык: Английский

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Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 10, 2023

Abstract Oral administration is preferred over other drug delivery methods due to its safety, high patient compliance, ease of ingestion without discomfort, and tolerance a wide range medications. However, oral limited by the poor bioavailability many drugs, caused extreme conditions absorption challenges in gastrointestinal tract. This review thoroughly discusses targeted vehicles intestinal lymphatic system (ILS). It explores structure physiological barriers ILS, highlighting significance dietary lipid medication transport. The presents various approaches targeting ILS using spatially precise vehicles, aiming enhance bioavailability, achieve delivery, reduce first-pass metabolism with serve clinic. Furthermore, outlines several for leveraging these open window, paving way potential clinical applications cancer treatment vaccine delivery. By focusing on this article emphasizes critical role strategies improving therapeutic efficacy outcomes. Overall, impact

Язык: Английский

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Recent advances in the therapeutic potential of nobiletin against respiratory diseases

Phytomedicine, Год журнала: 2024, Номер 128, С. 155506 - 155506

Опубликована: Март 1, 2024

Nobiletin is a natural polymethoxylated flavonoid widely present in citrus fruit peels. It has been extensively studied due to its wide range of pharmacological activities and considered potential therapeutic drug for various diseases. demonstrated exert the effects anti-tumor, anti-inflammation, anti-oxidative, anti-apoptotic improve cardiovascular function. Increasing evidences suggest that nobiletin plays an important role respiratory diseases (RDs) treatment. This review aimed investigate against RDs based on studies published PubMed, Web Science, Scopus databases English until June 26, 2023. We highlighted novel findings regarding mechanism treatment, such as lung cancer, COPD, pulmonary fibrosis, asthma, infection, acute injury, coronavirus disease 2019, arterial hypertension. These can be used agent preventing treating RDs.

Язык: Английский

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Solid Lipid Nanoparticles for Pulmonary Delivery of Biopharmaceuticals: A Review of Opportunities, Challenges, and Delivery Applications

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(7), С. 3084 - 3102

Опубликована: Июнь 3, 2024

Biopharmaceuticals such as nucleic acids, proteins, and peptides constitute a new array of treatment modalities for chronic ailments. Invasive routes remain the mainstay administering biopharmaceuticals due to their labile nature in biological environment. However, it is not preferred long-term therapy lack patient adherence clinical suitability. Therefore, alternative administration are sought utilize novel biopharmaceutical therapies utmost potential. Nanoparticle-mediated pulmonary delivery biologics can facilitate both local systemic disorders. Solid lipid nanoparticles (SLNs) afford many opportunities carriers physicochemical stability ability incorporate hydrophilic hydrophobic moieties, thus allowing combinatorial drug/gene therapies. These applications include infections, lung cancer, cystic fibrosis, while biomolecules, like insulin, also attractive This Review explores physiological particle-associated factors affecting biopharmaceuticals. It compares advantages limitations SLNs nanocarriers along with design improvements underway overcome these limitations. Current research illustrating various SLN designs deliver peptides, plasmids, oligonucleotides, siRNA, mRNA summarized.

Язык: Английский

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