Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 652 - 652
Опубликована: Фев. 15, 2023
Lung
cancer
is
one
of
the
deadliest
pulmonary
diseases
in
world.
Although
docetaxel
(DTX)
has
exhibited
superior
efficacy
lung
treatment,
it
demonstrated
numerous
adverse
effects
and
poor
bioavailability.
The
natural
product
extract,
curcumin
(CCM),
reportedly
reduced
toxicity
synergistically
improved
DTX
Nonetheless,
hydrophobic
nature
CCM
limits
their
clinical
use.
Nanoemulsion
delivery
potential
as
a
drug
carrier
to
alleviate
these
drawbacks.
controlled
preparation
inhalable
DTX-
CCM-loaded
nanoemulsions
within
100
200
nm
range
was
explored
this
study.
A
response
surface
methodology
(RSM)
based
on
central
composite
design
(CCD)
utilized
fabricate
desired
size
nanoemulsion
under
optimized
conditions.
Different
process
parameters
were
employed
control
procured
through
high-energy
emulsification
technique.
resultant
decreased
with
increasing
energy
input.
actual
according
targeted
sizes
for
models
excellent
agreement
predicted
value
at
below
5%
residual
standard
error
particle
better
membrane
permeability
than
larger
counterparts.
Moreover,
formulations
documented
favorable
physicochemical
aerodynamic
properties
human
fibroblast
(MRC-5)
cells.
Hence,
tunable
could
be
suitable
alternative
increased
local
concentration.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
659, С. 124248 - 124248
Опубликована: Май 21, 2024
Pulmonary
delivery
of
drugs
has
emerged
as
a
promising
approach
for
the
treatment
both
lung
and
systemic
diseases.
Compared
to
other
drug
routes,
inhalation
offers
numerous
advantages
including
high
targeting,
fewer
side
effects,
huge
surface
area
absorption.
However,
deposition
in
lungs
can
be
limited
by
defence
mechanisms
such
mucociliary
macrophages'
clearance.
Among
devices,
dry
powder
inhalers
represent
optimal
choice
due
their
stability,
ease
use,
absence
propellants.
In
last
decades,
several
bottom-up
techniques
have
over
traditional
milling
produce
inhalable
powders.
these
techniques,
most
employed
ones
are
spray
drying,
supercritical
fluid
technology,
freeze-drying,
thin
film
freezing.
Inhalable
powders
constituted
micronized
attached
coarse
carrier
(e.g.,
lactose)
or
embedded
into
micro-
nanoparticle.
Particulate-based
formulations
commonly
composed
polymeric
nanoparticles,
liposomes,
solid
lipid
dendrimers,
nanocrystals,
extracellular
vesicles,
inorganic
nanoparticles.
Moreover,
engineered
large
porous
particles,
swellable
microparticles,
nano-in-microparticles,
effervescent
nanoparticles
been
developed.
Particle
engineering
also
crucial
role
tuning
physical-chemical
properties
carrier-based
carrier-free
This
increase
flowability,
deposition,
targeting
customising
particle
features.
Advanced Materials,
Год журнала:
2022,
Номер
34(47)
Опубликована: Сен. 19, 2022
Above
50%
of
deaths
can
be
attributed
to
chronic
inflammatory
diseases;
thus,
the
construction
drug
delivery
systems
based
on
effective
interaction
factors
with
chemotactic
nanoparticles
is
meaningful.
Herein,
a
zwitterion-based
artificial
nanomotor
proposed
for
universal
precise
targeting
strategy
in
vivo,
where
high
level
reactive
oxygen
species
(ROS)
and
inducible
nitric
oxide
synthase
(iNOS)
sites
are
used
as
chemoattractant.
Multidimensional
static
models,
dynamic
vivo
models
established
evaluate
performance.
The
results
show
that
upregulated
ROS
iNOS
induce
chemotaxis
nanomotors
diseased
tissues
inflammation-related
disease
models.
Further,
mesoscale
hydrodynamics
simulations
performed
explain
behavior
nanomotors.
Such
expected
improve
efficiency
may
applicable
variety
diseases.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(4), С. 581 - 581
Опубликована: Апрель 12, 2023
Tuberculosis
(TB),
one
of
the
deadliest
contagious
diseases,
is
a
major
concern
worldwide.
Long-term
treatment,
high
pill
burden,
limited
compliance,
and
strict
administration
schedules
are
all
variables
that
contribute
to
development
MDR
XDR
tuberculosis
patients.
The
rise
multidrug-resistant
strains
scarcity
anti-TB
medications
pose
threat
TB
control
in
future.
As
result,
strong
effective
system
required
overcome
technological
limitations
improve
efficacy
therapeutic
medications,
which
still
huge
problem
for
pharmacological
technology.
Nanotechnology
offers
an
interesting
opportunity
accurate
identification
mycobacterial
improved
medication
treatment
possibilities
tuberculosis.
Nano
medicine
emerging
research
field
provides
possibility
efficient
delivery
using
nanoparticles
decrease
drug
dosages
adverse
effects
boost
patient
compliance
with
therapy
recovery.
Due
their
fascinating
characteristics,
this
strategy
useful
overcoming
abnormalities
associated
traditional
leads
some
optimization
impact.
It
also
decreases
dosing
frequency
eliminates
low
compliance.
To
develop
modern
diagnosis
techniques,
upgraded
possible
prevention
tuberculosis,
nanoparticle-based
tests
have
demonstrated
considerable
advances.
literature
search
was
conducted
Scopus,
PubMed,
Google
Scholar,
Elsevier
databases
only.
This
article
examines
employing
nanotechnology
diagnosis,
nanotechnology-based
systems,
successful
elimination
illnesses.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 393 - 393
Опубликована: Янв. 24, 2023
Tuberculosis
(TB)
is
currently
the
second
deadliest
infectious
disease.
Existing
antitubercular
therapies
are
long,
complex,
and
have
severe
side
effects
that
result
in
low
patient
compliance.
In
this
context,
nanosized
drug
delivery
systems
(DDSs)
potential
to
optimize
treatment’s
efficiency
while
reducing
its
toxicity.
Hundreds
of
publications
illustrate
growing
interest
field.
review,
main
challenges
related
use
nanocarriers
fight
TB
overviewed.
Relevant
regarding
DDSs
for
treatment
classified
according
encapsulated
drugs,
from
first-line
second-line
drugs.
The
physicochemical
biological
properties
investigated
formulations
listed.
could
simultaneously
(i)
therapy’s
antibacterial
effects;
(ii)
reduce
doses;
(iii)
posology;
(iv)
diminish
toxicity;
as
a
global
result,
(v)
mitigate
emergence
resistant
strains.
Moreover,
we
highlight
host-directed
therapy
using
nanoparticles
(NPs)
recent
promising
trend.
Although
research
on
expanding,
clinical
applications
yet
be
developed.
Most
studies
only
dedicated
development
new
formulations,
without
vivo
proof
concept.
near
future,
it
expected
NPs
prepared
by
“green”
scalable
methods,
with
intrinsic
capable
co-encapsulating
synergistic
may
find
TB.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Март 27, 2023
Inflammatory
lung
diseases
represent
a
persistent
burden
for
patients
and
the
global
healthcare
system.
The
combination
of
high
morbidity,
(partially)
mortality
limited
innovations
in
last
decades,
have
resulted
great
demand
new
therapeutics.
Are
therapeutic
IgA
antibodies
possibly
hope
treatment
inflammatory
diseases?
Current
research
increasingly
unravels
elementary
functions
as
protector
against
infections
modulator
overwhelming
inflammation.
With
focus
on
IgA,
this
review
describes
pathological
alterations
mucosal
immunity
how
they
contribute
to
chronic
inflammation
most
common
diseases.
current
knowledge
circulation,
particularly
respiratory
mucosa,
are
summarized.
interplay
between
neutrophils
seems
be
key
control
In
addition,
hurdles
benefits
antibodies,
well
currently
known
clinically
used
preparations
described.
data
highlighted
here,
together
with
upcoming
strategies
aiming
at
circumventing
pitfalls
may
pave
way
promising
antibody
class
application
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Авг. 10, 2023
Abstract
Oral
administration
is
preferred
over
other
drug
delivery
methods
due
to
its
safety,
high
patient
compliance,
ease
of
ingestion
without
discomfort,
and
tolerance
a
wide
range
medications.
However,
oral
limited
by
the
poor
bioavailability
many
drugs,
caused
extreme
conditions
absorption
challenges
in
gastrointestinal
tract.
This
review
thoroughly
discusses
targeted
vehicles
intestinal
lymphatic
system
(ILS).
It
explores
structure
physiological
barriers
ILS,
highlighting
significance
dietary
lipid
medication
transport.
The
presents
various
approaches
targeting
ILS
using
spatially
precise
vehicles,
aiming
enhance
bioavailability,
achieve
delivery,
reduce
first-pass
metabolism
with
serve
clinic.
Furthermore,
outlines
several
for
leveraging
these
open
window,
paving
way
potential
clinical
applications
cancer
treatment
vaccine
delivery.
By
focusing
on
this
article
emphasizes
critical
role
strategies
improving
therapeutic
efficacy
outcomes.
Overall,
impact
Phytomedicine,
Год журнала:
2024,
Номер
128, С. 155506 - 155506
Опубликована: Март 1, 2024
Nobiletin
is
a
natural
polymethoxylated
flavonoid
widely
present
in
citrus
fruit
peels.
It
has
been
extensively
studied
due
to
its
wide
range
of
pharmacological
activities
and
considered
potential
therapeutic
drug
for
various
diseases.
demonstrated
exert
the
effects
anti-tumor,
anti-inflammation,
anti-oxidative,
anti-apoptotic
improve
cardiovascular
function.
Increasing
evidences
suggest
that
nobiletin
plays
an
important
role
respiratory
diseases
(RDs)
treatment.
This
review
aimed
investigate
against
RDs
based
on
studies
published
PubMed,
Web
Science,
Scopus
databases
English
until
June
26,
2023.
We
highlighted
novel
findings
regarding
mechanism
treatment,
such
as
lung
cancer,
COPD,
pulmonary
fibrosis,
asthma,
infection,
acute
injury,
coronavirus
disease
2019,
arterial
hypertension.
These
can
be
used
agent
preventing
treating
RDs.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(7), С. 3084 - 3102
Опубликована: Июнь 3, 2024
Biopharmaceuticals
such
as
nucleic
acids,
proteins,
and
peptides
constitute
a
new
array
of
treatment
modalities
for
chronic
ailments.
Invasive
routes
remain
the
mainstay
administering
biopharmaceuticals
due
to
their
labile
nature
in
biological
environment.
However,
it
is
not
preferred
long-term
therapy
lack
patient
adherence
clinical
suitability.
Therefore,
alternative
administration
are
sought
utilize
novel
biopharmaceutical
therapies
utmost
potential.
Nanoparticle-mediated
pulmonary
delivery
biologics
can
facilitate
both
local
systemic
disorders.
Solid
lipid
nanoparticles
(SLNs)
afford
many
opportunities
carriers
physicochemical
stability
ability
incorporate
hydrophilic
hydrophobic
moieties,
thus
allowing
combinatorial
drug/gene
therapies.
These
applications
include
infections,
lung
cancer,
cystic
fibrosis,
while
biomolecules,
like
insulin,
also
attractive
This
Review
explores
physiological
particle-associated
factors
affecting
biopharmaceuticals.
It
compares
advantages
limitations
SLNs
nanocarriers
along
with
design
improvements
underway
overcome
these
limitations.
Current
research
illustrating
various
SLN
designs
deliver
peptides,
plasmids,
oligonucleotides,
siRNA,
mRNA
summarized.