Progress in approved drugs from natural product resources

Chinese Journal of Natural Medicines, Год журнала: 2024, Номер 22(3), С. 195 - 211

Опубликована: Март 1, 2024

Язык: Английский

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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 121 - 121

Опубликована: Янв. 16, 2025

In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made effective drug design. Drug targeting aims ensure that acts only pathological area; it defined as ability accumulate selectively quantitatively target tissue or organ, regardless of chemical structure active substance method administration. With targeting, conventional, biotechnological gene-derived drugs body’s organs, tissues, cells can be transported specific regions. These systems serve carriers regulate timing release. Despite having many advantageous features, these have limitations thoroughly treating complex diseases such cancer. Therefore, combining with nanoparticle technologies imperative treat cancer at both local systemic levels effectively. The nanocarrier-based delivery involves encapsulating target-specific molecules into polymeric vesicular systems. Various (DDS) were investigated discussed this review article. first part passive systems, hydrogels, thermoplastics, microdevices transdermal-based second carrier nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles smart nanogels). third part, advantages discussed, finally, market research commercial used nanotechnological approaches was included.

Язык: Английский

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Lactoferrin-functionalized PEGylation liposomes loaded with norcantharidin acid for targeted therapy of hepatocellular carcinoma

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125245 - 125245

Опубликована: Янв. 1, 2025

Язык: Английский

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Targeted drug delivery systems for elemene in cancer therapy: The story thus far

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 166, С. 115331 - 115331

Опубликована: Авг. 18, 2023

Elemene (ELE) is a group of broad-spectrum anticancer active ingredients with low toxicity extracted from traditional Chinese medicines (TCMs), such as Curcumae Rhizoma and Curcuma Radix, which can exert antitumour activities by regulating various signal pathways targets. However, the strong hydrophobicity, short half-life, bioavailability weak in vivo targeting ability ELE restrict its use. Targeted drug delivery systems based on nanomaterials are among most viable methods to overcome these shortcomings. In this review, we first summarize recent studies clinical uses an adjunct drug. ELE-based combination strategies have great promise for enhancing efficacy, reducing adverse reactions, improving patients' quality life immune function. Second, mechanisms strategies. The potential include inducing pyroptosis ferroptosis, promoting senescence, METTL3-mediated m6A modification, suppressing Warburg effect, apoptosis cell cycle arrest. Most importantly, comprehensively targeted ELE, including passively actively systems, stimuli-responsive codelivery combined other therapies, bioavailability, increasing ability, controlling release, effects reversing MDR. Our summary will provide reference TCMs advanced future.

Язык: Английский

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Nanotechnology-based non-viral vectors for gene delivery in cardiovascular diseases

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Янв. 18, 2024

Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous into target cells to cure the disease. Although gene has gained some accomplishment for diagnosis and of inherited acquired cardiovascular diseases, how efficiently specifically deliver targeted lesion sites without being cleared blood system remains challenging. Based on nanotechnology development, non-viral vectors provide promising strategy overcoming difficulties in therapy. At present, according physicochemical properties, nanotechnology-based include polymers, liposomes, lipid nanoparticles, inorganic nanoparticles. Non-viral have an advantage safety, efficiency, easy production, possessing potential clinical application value when compared with viral vectors. Therefore, we summarized recent research progress diseases based commonly used vectors, hopefully providing guidance orientation future relevant research.

Язык: Английский

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Inhibitory effects of norcantharidin on titanium particle-induced osteolysis, osteoclast activation and bone resorption via MAPK pathways

International Immunopharmacology, Год журнала: 2024, Номер 129, С. 111655 - 111655

Опубликована: Фев. 9, 2024

Язык: Английский

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Chitosan-modified mesoporous silica nanoparticles for the oral delivery of Norcantharidin: In vitro and in vivo assessment

Microporous and Mesoporous Materials, Год журнала: 2024, Номер 369, С. 113013 - 113013

Опубликована: Фев. 6, 2024

Язык: Английский

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Norcantharidin Enhances the Antitumor Effect of 5-Fluorouracil by Inducing Apoptosis of Cervical Cancer Cells: Network Pharmacology, Molecular Docking, and Experimental Validation

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(5), С. 3906 - 3918

Опубликована: Апрель 25, 2024

The high recurrence rate of cervical cancer is a leading cause deaths in women. 5-Fluorouracil (5-FU) an antitumor drug used to treat many types cancer, but its diminishing effectiveness and side effects limit use. Norcantharidin (NCTD), demethylated derivative cantharidin, exhibits various biological activities. Here, we investigated whether NCTD could potentiate 5-FU induce cell death. To assess the viability synergistic drugs, counting kit-8 colony formation assays were performed using HR-HPV-positive lines. Annexin V-FITC/PI staining TUNEL confirm induction apoptosis. effect on activity was analyzed network pharmacology, molecular docking, dynamics simulations. Apoptosis-related proteins examined immunoblotting. combination Network pharmacological analysis identified 10 common targets for treatment. Molecular docking showed strong binding affinity both compounds with CA12, CASP9, PTGS1. simulations that complex system drugs caspase-9 be stable state. enhanced 5-FU-mediated cytotoxicity by activating apoptosis-related proteins. acts synergistically inhibit proliferation. enhances 5-FU-induced apoptosis lines via caspase-dependent pathway.

Язык: Английский

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Exploration of the regulatory mechanism of Norcantharidin on sine oculis homeobox homolog 4 in colon cancer using transcriptome sequencing and bioinformatic

Journal of Traditional Chinese Medical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 3, 2025

Background Norcantharidin (NCTD), a bioactive compound derived from traditional Chinese medicine, has demonstrated promising anticancer activity against multiple malignancies, particularly hepatocellular carcinoma (HCC). However, its epigenetic regulatory mechanisms and associated transcriptional consequences remain poorly characterized. Methods In this study, we integrated biochemical assays with panel of cellular analyses assessing cell viability, proliferation, colony formation, migratory capacity to investigate NCTD’s therapeutic potential in HCC progression. Potential molecular targets NCTD were systematically identified through network pharmacology approaches. Chromatin immunoprecipitation quantitative PCR (ChIP-qPCR) was performed quantify H3K27me3 enrichment level at the TOP2A locus NCTD-treated cells. Molecular docking simulations employed examine structural interactions between EZH2 (enhancer zeste homolog 2), while co-immunoprecipitation further conducted validate protein-protein protein phosphatase 1 (PP1). Results We topoisomerase IIα (TOP2A) as critical target mediating anti-HCC effects. Functional characterization revealed that significantly attenuated proliferation induced G2/M phase cycle arrest disruption TOP2A-p53 signaling axis. Mechanistic investigations epigenetically suppresses transcription via PRC2 (Polycomb Repressive Complex 2)-mediated deposition repressive histone mark promoter. Structural biology confirmed direct binding protein, consequently impairing PP1-mediated dephosphorylation enhancing complex stability. Conclusion Our findings establish exerts effects silencing TOP2A. This work not only elucidates novel pharmacoepigenetic mechanism underlying antitumor but also provides translational rationale for developing PRC2-targeted strategies management.

Язык: Английский

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