ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(4), С. 2251 - 2269
Опубликована: Март 7, 2024
Diabetic
wound
healing
remains
a
worldwide
challenge
for
both
clinicians
and
researchers.
The
high
expression
of
matrix
metalloproteinase
9
(MMP9)
inflammatory
response
are
indicative
poor
diabetic
healing.
H8,
curcumin
analogue,
is
able
to
treat
diabetes
anti-inflammatory,
our
pretest
showed
that
it
has
the
potential
However,
H8
highly
expressed
in
organs
such
as
liver
kidney,
resulting
its
unfocused
use
targeting.
(These
data
were
not
published,
see
Table
S1
Supporting
Information.)
Accordingly,
important
pursue
effective
carrier
vehicles
facilitate
therapeutic
uses
H8.
delivered
by
macrophage
membrane-derived
nanovesicles
provides
strategy
repairing
wounds
with
improved
drug
efficacy
fast
In
this
study,
we
fabricated
an
injectable
gelatin
microsphere
(GM)
sustained
MMP9-responsive
(H8NVs)
targeted
release
promote
angiogenesis
also
reduces
oxidative
stress
damage
inflammation,
promoting
Gelatin
microspheres
loaded
H8NV
(GMH8NV)
stimulated
MMP9
can
significantly
migration
NIH-3T3
cells
development
tubular
structures
HUVEC
vitro.
addition,
results
demonstrated
GMH8NV
protected
from
polarized
macrophages
M2
phenotype,
leading
inflammation
inhibition.
By
stimulating
collagen
deposition,
inhibiting
reducing
expression,
accelerated
This
study
GMH8NVs
after
stimulation,
suggesting
promising
achieving
satisfactory
treatment.
Materials Today Bio,
Год журнала:
2023,
Номер
20, С. 100633 - 100633
Опубликована: Апрель 12, 2023
With
the
development
of
nanotechnology,
nanoparticles
have
emerged
as
a
delivery
carrier
for
tumor
drug
therapy,
which
can
improve
therapeutic
effect
by
increasing
stability
and
solubility
prolonging
half-life
drugs.
However,
are
foreign
substances
humans,
easily
cleared
immune
system,
less
targeted
to
tumors,
may
even
be
toxic
body.
As
natural
biological
material,
cell
membranes
unique
properties,
such
good
biocompatibility,
strong
targeting
ability,
ability
evade
surveillance,
high
drug-carrying
capacity.
In
this
article,
we
review
membrane-coated
(CMNPs)
their
applications
therapy.
First,
briefly
describe
CMNP
characteristics
applications.
Second,
present
advantages
different
well
nanoparticles,
provide
brief
description
process
CMNPs,
discuss
current
status
application
summarize
shortcomings
use
in
cancer
propose
future
research
directions.
This
summarizes
progress
on
CMNPs
therapy
recent
years
assesses
remaining
problems,
providing
scholars
with
new
ideas
Oral
medication
for
ulcerative
colitis
(UC)
is
often
hindered
by
challenges
such
as
inadequate
accumulation,
limited
penetration
of
mucus
barriers,
and
the
intricate
task
mitigating
excessive
ROS
inflammatory
cytokines.
Here,
we
present
a
strategy
involving
sodium
alginate
microspheres
(SAMs)
incorporating
M2
macrophage
membrane
(M2M)-coated
Janus
nanomotors
(denominated
Motor@M2M)
targeted
treatment
UC.
SAM
provides
protective
barrier,
ensuring
that
Motor@M2M
withstands
harsh
gastric
milieu
exhibits
controlled
release.
M2M
enhances
targeting
precision
to
tissues
acts
decoy
neutralization
Catalytic
decomposition
H
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(19)
Опубликована: Янв. 4, 2024
Abstract
The
blood–brain
barrier
(BBB)
is
a
tailored
system
of
capillary
endothelial
cells
intermixed
with
tight
junctions
and
adherent
that
regulates
the
transport
various
materials
substances
between
blood
vasculature
central
nervous
(CNS).
However,
in
cases
brain
diseases,
BBB's
protective
regulatory
effects
hamper
therapeutics
from
reaching
affected
sites
sufficient
quantities.
This
has
so
far
been
leading
challenge
treating
CNS
diseases
disorders.
For
this
problem
to
be
overcome,
recent
research
sought
develop
novel
modalities
achieve
efficient
therapy
alleviate
associated
symptoms.
Therefore,
numerous
strategies
have
operated
years
address
limitations
traditional
invasive
methods,
including
poor
penetration
serious
side
effects.
As
desperately
in‐demand
technology,
nanotheranostics
particularly
shown
promising
results.
Herein,
review
reports
advancements
techniques
nanotechnology‐based
developed
for
neurodegenerative
study
provides
comprehensive
data
on
subject
used
future
studies
management
disorders
diseases.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Апрель 3, 2024
Abstract
Glioblastoma
(GBM)
is
the
most
aggressive
and
prevalent
primary
malignant
tumor
of
central
nervous
system.
Traditional
chemotherapy
has
poor
therapeutic
effects
significant
side
due
to
drug
resistance,
natural
blood‐brain
barrier
(BBB),
nonspecific
distribution,
leading
a
lack
clinically
effective
drugs.
Here,
1430
small
molecule
compounds
are
screened
based
on
high‐throughput
screening
platform
novel
anti‐GBM
drug,
lomitapide
(LMP)
obtained.
Furthermore,
bionic
nanodrug
delivery
system
(RFA
NPs)
actively
targeting
GBM
constructed,
which
mainly
consists
tetrahedral
DNA
nanocages
(tFNA
loaded
with
LMP
as
core
folate‐modified
erythrocyte–cancer
cell–macrophage
hybrid
membrane
(FRUR)
shell.
FRUR
camouflage
conferred
unique
features
tFNA
NPs,
including
excellent
biocompatibility,
improved
pharmacokinetic
profile,
efficient
BBB
permeability,
ability.
The
results
show
that
RFA
NPs
exhibited
superior
specific
activities,
reduced
off‐target
delivery,
prolonged
lifespan,
negligible
in
tumor‐bearing
mice.
This
study
combines
biomimetic
technology
provide
theoretical
practical
basis
for
development
optimization
clinical
treatment
strategies
treatment.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 4, 2025
The
tumor
microenvironment
(TME)
is
a
complex
and
dynamic
ecosystem
that
plays
critical
role
in
cancer
progression.
It
comprises
various
cell
types,
including
immune
cells,
stromal
cells.
Among
these,
cancer-associated
fibroblasts
(CAFs)
represent
heterogeneous
population
with
diverse
origins,
phenotypes,
functions.
Activated
CAFs
secrete
multiple
factors
promote
growth,
migration,
angiogenesis,
contribute
to
chemoresistance.
Additionally,
extracellular
matrix
(ECM)
components,
such
as
collagen,
which
form
physical
barrier
hinders
the
penetration
of
chemotherapeutic
immunotherapeutic
agents.
This
ECM
also
influences
infiltration,
impeding
their
ability
effectively
target
As
result,
modulating
activity
has
emerged
promising
strategy
enhance
efficacy
immunotherapy.
Nano-delivery
systems,
constructed
from
nanomaterials
high
targeting
specificity
biocompatibility,
offer
compelling
approach
deliver
therapeutic
agents
or
immunomodulatory
directly
CAFs.
modulation
can
alter
CAF
function,
reduce
tumor-promoting
effects,
thereby
improve
outcomes
review
provides
an
in-depth
exploration
functions,
interactions
within
TME,
particularly
context
suppression.
Furthermore,
it
discusses
potential
applications
functional
nanocarrifers
enhancing
effectiveness
immunotherapy,
highlighting
significant
progress
nanotechnology
this
area.
Coatings,
Год журнала:
2023,
Номер
13(8), С. 1420 - 1420
Опубликована: Авг. 13, 2023
In
response
to
increasing
concerns
over
food
waste
and
safety,
the
environmental
impacts
of
traditional
conservation
methods,
this
review
aims
explore
potential
bio-coatings
in
preserving
freshness
fruits
vegetables.
Our
primary
objective
is
provide
a
comprehensive
analysis
recent
advancements
bio-coating
technologies,
detailing
their
benefits
terms
enhancing
prolonging
shelf
life,
reducing
waste.
This
paper
delves
into
various
forms
bio-coatings,
applications,
effectiveness
maintaining
post-harvest
quality.
We
further
elucidate
underlying
mechanisms
that
govern
preservation
efficacy.
intended
for
researchers,
industry
professionals,
policy
makers
who
are
interested
sustainable
alternatives
implications
security
sustainability.
By
end
review,
audience
will
gain
thorough
understanding
current
state
technology
its
prospects
industry.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 150 - 166
Опубликована: Янв. 27, 2024
Neutrophils
have
recently
emerged
as
promising
carriers
for
drug
delivery
due
to
their
unique
properties
including
rapid
response
toward
inflammation,
chemotaxis,
and
transmigration.
When
integrated
with
nanotechnology
that
has
enormous
advantages
in
improving
treatment
efficacy
reducing
side
effects,
neutrophil-based
nano-drug
systems
expanded
the
repertoire
of
nanoparticles
employed
precise
therapeutic
interventions
by
either
coating
membranes,
loading
inside
living
cells,
or
engineering
chimeric
antigen
receptor
(CAR)-neutrophils.
These
neutrophil-inspired
therapies
shown
superior
biocompatibility,
targeting
ability,
robustness.
In
this
review,
we
summarized
benefits
combining
neutrophils
nanotechnologies,
design
principles
underlying
mechanisms,
various
applications
disease
treatments.
The
challenges
prospects
were
also
discussed.
