BMC Oral Health, Год журнала: 2024, Номер 24(1)
Опубликована: Июль 24, 2024
To investigate the potential mechanisms of shikonin in preventing and treating periodontitis using network pharmacology molecular docking methods.
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
Traditional treatments for periodontitis are limited by their inability to adequately modulate the immune response and control inflammation. Recently, nucleic acid-modified nanomaterials have attracted significant attention potential in regulating Among these, most nanomaterials, such as spherical acids, tend exhibit pro-inflammatory effects. In this study, we identified first time that poly-T sequence-modified gold nanorods (PTM AuNRs) possess anti-inflammatory properties. The PTM AuNRs demonstrated excellent biocompatibility efficacy treating ligation-induced periodontitis. responses inhibiting differentiation of M1 macrophages reducing cytokine levels through promoting AMPK activation. When administered via local injection, effectively suppress inflammatory cell infiltration, downregulate levels, mitigate collagen fiber degradation alveolar bone loss. Together, these findings highlight a promising innovative therapeutic strategy management.
Язык: Английский
Процитировано
0
Molecular Diagnosis & Therapy, Год журнала: 2023, Номер 27(6), С. 703 - 722
Опубликована: Сен. 29, 2023
Язык: Английский
Процитировано
10
Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 727, С. 150336 - 150336
Опубликована: Июнь 30, 2024
Myocardial fibrosis involves the loss of cardiomyocytes, myocardial fibroblast proliferation, and a reduction in angiogenesis, ultimately leading to heart failure, Given its significant implications, it is crucial explore novel therapies for fibrosis. Recently one emerging avenue has been use small extracellular vesicles (sEV)-carried miRNA. In this review, we summarize regulatory role sEV-carried miRNA We explored not only potential diagnostic value circulating as biomarkers disease but also therapeutic implications derived from various cellular sources applications modified sEV. This exploration paramount researchers striving develop innovative, cell-free drug candidates management
Язык: Английский
Процитировано
3
Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2023, Номер 386(2), С. 212 - 223
Опубликована: Май 15, 2023
Recent advances in the RNA delivery system have facilitated development of a separate field therapeutics, with modalities including mRNA, miRNA, antisense oligonucleotide (ASO), siRNA, and circular (circRNA) that been incorporated into oncology research. The main advantages RNA-based are high flexibility designing rapid production for clinical screening. It is challenging to eliminate tumors by tackling single target cancer. In era precision medicine, therapeutic approaches potentially constitute suitable platforms targeting heterogeneous possess multiple sub-clonal cancer cell populations. this review, we discussed how synthetic coding non-coding RNAs, such as ASO, circRNA, can be applied therapeutics. Significance Statement With vaccines against coronavirus, therapeutics received attention. Here, discuss different types effective tumor highly giving rise resistance relapses conventional Moreover, summarized recent findings suggesting combination immunotherapy.
Язык: Английский
Процитировано
8
BMC Oral Health, Год журнала: 2024, Номер 24(1)
Опубликована: Июль 24, 2024
To investigate the potential mechanisms of shikonin in preventing and treating periodontitis using network pharmacology molecular docking methods.
Язык: Английский
Процитировано
2